
27/08/2025
☢️Summary of the Role of Diffusion MRI in brain imaging ☢️
✅Diffusion-Weighted Imaging (DWI) and its derived techniques like Diffusion Tensor Imaging (DTI) play a key role in neuroradiology because it gives information about the microscopic motion of water molecules in brain tissue, which reflects both tissue structure and pathology.
Here’s a structured overview of the role:
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1. Acute Ischemic Stroke
• Most important role: DWI can detect ischemia within minutes of onset (much earlier than CT or conventional MRI).
• Acute infarct appears as restricted diffusion (bright on DWI, dark on ADC map).
• Helps in guiding thrombolysis/thrombectomy decisions.
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2. Brain Tumors
• Diffusion helps differentiate:
• High-grade vs low-grade tumors (high cellularity = restricted diffusion).
• Tumor recurrence vs radiation necrosis (recurrence shows lower ADC).
• Provides information about tumor infiltration and margins.
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3. Infections
• Abscess vs cystic/necrotic tumor: abscess shows marked diffusion restriction due to pus, while necrotic tumor usually does not.
• Encephalitis: areas of restricted diffusion can be seen, especially in herpes simplex encephalitis.
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4. White Matter Diseases
• Multiple Sclerosis (MS): DTI reveals microstructural white matter damage even in normal-appearing white matter.
• Helps quantify fractional anisotropy (FA) and tract integrity.
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5. Traumatic Brain Injury (TBI)
• Detects diffuse axonal injury (DAI) not visible on CT or conventional MRI.
• DTI shows reduced FA in injured tracts.
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6. Epilepsy
• DWI can detect acute seizure-related changes (transient restricted diffusion).
• DTI assists in presurgical mapping of eloquent white matter tracts (e.g., corticospinal tract, arcuate fasciculus).
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7. Other Roles
• Hydrocephalus: differentiates between obstructive vs non-obstructive causes.
• Cerebral infections (e.g., Creutzfeldt-Jakob disease): shows cortical ribboning and basal ganglia hyperintensity on DWI.
• Normal pressure hydrocephalus vs atrophy: diffusion parameters may help.
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✅ In summary:
Diffusion MRI is crucial in early stroke detection, tumor characterization, infection diagnosis, white matter integrity assessment, and pre-surgical brain mapping. It is one of the most clinically impactful MRI techniques in modern neuroradiology.