22/06/2025
Breast Cancer Alert: How Tumors Spread!
In this case study, a 44-year-old woman presents with a hard, fixed breast mass and axillary lymph node involvement. The histopathology confirms ductal adenocarcinoma with local metastasis.
But how do cancer cells spread from the primary tumor to lymph nodes?
𧬠In this video, we break down the molecular mechanisms of metastasis:
π½ Downregulation of E-cadherin for cell detachment
π Altered integrin expression for invasion
π¨ Secretion of collagenases to pe*****te the ECM
π Entry into lymphatic or blood vessels for systemic spread
Perfect for USMLE, PLAB and medical revision.
π Simplified, clinical, and exam-focused!
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