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Potassium citrate is rapidly absorbed when given by mouth, and is excreted in the urine.[4] Since it is an alkaline salt, it is effective in reducing the pain and frequency of urination when these are caused by highly acidic urine.[5] It is used for this purpose in dogs and cats, but is chiefly employed as a non-irritating diuretic.

Potassium citrate is an effective way to treat/manage arrhythmia,[medical citation needed] if the patient is hypokalemic.

It is widely used to treat urinary calculi (kidney stones), and is often used by patients with cystinuria.[medical citation needed] A systematic review showed a significant reduction in the incidence of stone formation RR 0.26, 95% CI 0.10 to 0.68.[6]

It is also used as an alkalizing agent in the treatment of mild urinary tract infections, such as cystitis.[7]

It is also used in many soft drinks as a buffering agent.[8]

Frequently used in an aqueous solution with other potassium salts, it is a wet chemical fire suppressant that is particularly useful against kitchen fires.[9] Its alkaline pH encourages saponification to insulate the fuel from oxidizing air, and the endothermic dehydration reaction absorbs heat energy to reduce temperatures.[10][11]

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