Chronic urinary tract infection (chronic UTI) is a largely unrecognised condition that affects many people, with the majority being women. Most will never receive an accurate diagnosis or appropriate treatment for their condition.
Anyone can develop a chronic UTI and researchers say the biggest risk factor is having had a UTI. Between 25โ35 percent of people treated for a normal, acute UTI fail that treatment and many go on to develop a complicated, embedded infection that is more difficult to diagnose and treat (1-3).
If you have UTI symptoms but your test results come back negative, you may have good reason to question these tests. UTI testing (dipsticks and MSU cultures) has staggering failure rates. Research shows these tests miss at least half of infections (4-9).
Inadequate testing and treatment failures contribute to the development of chronic UTI. This condition is not widely recognised or understood and has no diagnostic or treatment guidelines (10).
Find out more about chronic UTI by visiting www.chronicutiaustralia.org.au
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1 Milo, G., et al., Duration of antibacterial treatment for uncomplicated urinary tract infection in women. Cochrane Database Syst Rev, 2005(2): p. CD004682.
2 Cited in Malone-Lee J, Urinary infections are complex and hard to treat, BMJ 2017;359:j4784 https://www.bmj.com/content/359/bmj.j5766.full?ijkey=IiTCSBtWau0sm9j&keytype=ref
3 Zalmanovici TA, Green H, Paul M, Yaphe J, Leibovici L. Antimicrobial agents for treating uncomplicated urinary tract infection in women. CochraneDatabaseSystRev. 2010;(10):CD007182.
4 Diagnosing UTIs is โa dogโs breakfast,โ and thatโs affecting women, The Current broadcast, www.cbc.ca/player/play/1201579075817 (Accessed online 15 September 2018)
5 Khasriya R, Khan S, Lunawat R, Bishara S, Bignal J, Malone-Lee M, et al. The Inadequacy of Urinary Dipstick and Microscopy as Surrogate Markers of Urinary Tract Infection in Urological Outpatients With Lower Urinary Tract Symptoms Without Acute Frequency and Dysuria. JUrol. 2010;183(5):1843-7.
6 Kupelian AS, Horsley H, Khasriya R, Amussah RT, Badiani R, Courtney AM, et al. Discrediting microscopic pyuria and leucocyte esterase as diagnostic surrogates for infection in patients with lower urinary tract symptoms: results from a clinical and laboratory evaluation. BJU Int. 2013;112(2):231-8. doi: 10.1111/j.1464-410X.2012.11694.x. PubMed PMID: 23305196.
7 Brubaker L, Wolfe AJ. The Female Urinary Microbiota/Microbiome: Clinical and Research Implications. Rambam Maimonides medical journal. 2017;8(2). Epub 2017/05/04. doi: 10.5041/rmmj.10292. PubMed PMID: 28467757; PubMed Central PMCID: PMCPMC5415361.
8 Gill K, Kang R, Sathiananthamoorthy S, Khasriya R, Malone-Lee J. A blinded observational cohort study of the microbiological ecology associated with pyuria and overactive bladder symptoms. Int Urogynecol J. 2018. Epub 2018/02/20. doi: 10.1007/s00192-018-3558-x. PubMed PMID: 29455238
9 Sanchutha Sathiananthamoorthy, James Malone-Lee, Kiren Gill, Anna Tymon, Trang K. Nguyen, Shradha Gurung, Linda Collins, Anthony S. Kupelian, Sheela Swamy, Rajvinder Khasriya,David A. Spratt, Jennifer L. Rohn. Reassessment of Routine Midstream Cutlure in the Diagnosis of Urinary Tract Infection. ASM Journal of Clinical Microbiology. 2019. DIOL 10.1128/JCM.01452-18 https://jcm.asm.org/content/57/3/e01452-18
10 https://www.racgp.org.au/your-practice/guidelines/silverbook/common-clinical-conditions/urinary-tract-infections/