
07/09/2025
More and more doctors are prescribing body-identical progesterone for premenstrual or perimenopausal mood symptoms. That’s great because for most women, it works beautifully.
But for some, progesterone can worsen mood thanks largely to its “biphasic” (Goldilocks) effect on GABA receptors, plus the fact that some women have less adaptable GABA receptors due to genetics, histamine, or inflammation.
If you’ve ever had a negative mood reaction to progesterone, consider:
⭐️ Was it actually a progestin (synthetic), not progesterone? If so, body-identical could still be fine.
⭐️ If it was natural progesterone, you may still be able to tolerate it by:
– lowering inflammation, histamine, or estrogen
– or even going up in dose, not down (but check with your clinician).
⭐️ Doses over 400 mg can knock you out—causing grogginess or even depression, especially if taken during the day.
Read my fully updated article: https://www.larabriden.com/progesterone-mood-treat-pmdd/?8Sept2025
And share your knowledge. Your story could help another woman. 💛