05/07/2022
🧫Alterations to the gut microbiota induces testicular dysfunction in a mice model 🦠
In this study published Nov 2021 in Biomed Central, researchers induced testicular dysfunction in mice by use of Triptolide, among other effects it is known to induce testicular toxicity, however the mechanism remained unclear ☠️
The researchers find that Triptolide causes s***mine (a polyamine) deficiency by disrupting polyamine biosynthesis undertaken by the gut microbiota. 🔬
After treating these mice with s***mine, triptolide-induced testicular dysfunction was reversed. ✅
To assess the role that the gut microbiota played here, they treated healthy mice with antibiotics. The loss of their microbiota depleted s***mine levels in the intestine and potentiated testicular dysfunction. 📈
Finally, the triptolide-treated mice received a gut microbial transplantation from untreated mice and the testicular dysfunction was reversed. 📉
So what did this mean ❓
- Negative alterations to the gut microbiota can induce testicular dysfunction ✔️
- More evidence showing how exogenous toxins are driving male infertility ✔️
- Improving the gut microbiota may be a therapeutic target for male infertility ✔️
Zhao, Q., Huang, J. F., Cheng, Y., Dai, M. Y., Zhu, W. F., Yang, X. W., Gonzalez, F. J., & Li, F. (2021). Polyamine metabolism links gut microbiota and testicular dysfunction. Microbiome, 9(1), 224. https://doi.org/10.1186/s40168-021-01157-z