16/08/2025                                                                            
                                    
                                    
                                                                        
                                        Emerging evidence shows that deficiencies in certain nutrients — Omega-3 fatty acids, Vitamin D, Vitamin B12, Vitamin B6, and folate — are strongly linked to depression and other mental disorders. 
Omega-3s, especially EPA and DHA from fish oils, are key components of brain cell membranes, influencing mood-regulating neurotransmitters like serotonin and dopamine. Vitamin D, found in fish oils and produced by sunlight exposure, supports brain development, DNA repair, and protection against oxidative stress. Low levels during pregnancy or early life may increase the risk of conditions like autism and depression.
Vitamin B12 and folate are essential for DNA synthesis, myelin formation, and neurotransmitter production. Deficiencies can cause cognitive decline, mood disturbances, and reduced response to antidepressants.
Folate, particularly in its active form L-methylfolate, boosts dopamine, norepinephrine, and serotonin synthesis, and genetic variations like the MTHFR C677T mutation can worsen mood disorders. 
Vitamin B6 plays a role in neurotransmitter synthesis and homocysteine regulation, with deficiencies linked to depression and neurological symptoms.
The literature highlights that addressing these nutrient gaps — through diet or supplementation — can be a simple, cost-effective way to improve mental well-being and potentially enhance treatment outcomes.
Source:
Lata Kanyal Butola et al, "Role of Omega 3 Fatty acids, Vitamin D, Vitamin B12, Vitamin B6 and Folate in Mental wellbeing-A Short review of Literature.", Indian Journal of Forensic Medicine & Toxicology (2021)