
22/08/2025
A recent study identified four key factors that can predict cognitive decline in Alzheimer's patients: age, s*x (female), atrial fibrillation (irregular heart rhythms), and daily activity levels.
Researchers followed 500 patients for two years, logging demographic, health, and functional data. These four predictors, recorded at the beginning of the study, accounted for roughly 14% of the variation in cognitive functioning at the study's end. The study also highlighted that caregiver burden increased as cognitive abilities declined. The research emphasizes a comprehensive treatment approach considering both patient and caregiver variables in early-stage Alzheimer's.
While smoking and drinking habits were not accounted for, the findings suggest demographics, medical history, and daily activity can predict cognitive decline caused by Alzheimer's.
In summary, being older, being female, having difficulty with daily activities, and having a history of atrial fibrillation (issues with irregular heart rhythms) were identified by the researchers as predicting the biggest declines in cognitive ability.
đ RESEARCH PAPER:
đ Kaufmann L. et al. (2024) "Predictive value of somatic and functional variables for cognitive deterioration for early-stage patients with Alzheimerâs Disease: Evidence from a prospective registry on dementia" (PLOS One)