π–―π—‹π—ˆπ–Ώπ–Ύπ—Œπ—Œπ—ˆπ—‹ π–£π—‚π—‘π—ˆπ—‡

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π–―π—‹π—ˆπ–Ώπ–Ύπ—Œπ—Œπ—ˆπ—‹ π–£π—‚π—‘π—ˆπ—‡ I’ve spent years exploring how obesity and metabolic health interact.

If you’re curious, I’d love for you to read my workβ€”or reach out for a chat about the science.

This is our lab of excellence in medical science and technology. We’ve got a top-tier team of highly qualified scientist...
13/08/2025

This is our lab of excellence in medical science and technology. We’ve got a top-tier team of highly qualified scientists and researchers with advanced training and vast experience. Our technical staff are experts in a variety of lab techniques and equipment. We also have a solid administrative and support team ensuring everything runs smoothly day-to-day.
We’ve invested in state-of-the-art equipment, including microscopes, centrifuges, PCR machines, flow cytometers, and more. Our computer systems are up to scratch for all the data storage, processing, and analysis we need.
We hold ourselves to the highest standards of safety and hygiene, with robust biosecurity measures, including cabinets, sterile areas, and waste management. We also have strict safety protocols for chemical handling and storage, as well as personal protective gear for staff, regular safety training, and first-aid training to keep everyone safe.

18/07/2025

Weight loss does not equal metabolic improvement? Surgery may rewire the body’s internal systems
New research from Duke University and Columbia University shows that gastric bypass surgery not only supports weight loss but also triggers profound metabolic changes that dieting alone cannot achieve.
In a study involving severely obese patients with type 2 diabetes:
Both the surgery and diet groups lost approximately 10 kilograms
However, only the surgery group showed a significant decrease in circulating branched-chain amino acids (BCAAs), which are strongly associated with insulin resistance
Why is this significant?
A reduction in BCAAs is linked to improved insulin sensitivity, better glucose control, and in many cases, remission of diabetes β€” often occurring before significant weight loss is observed.
Additional findings:
Gastric bypass surgery increases the secretion of GLP-1, a hormone produced in the gut that enhances insulin response
It also slows nutrient absorption, helping to stabilize blood sugar levels
This research underscores the underestimated role of the gut in energy regulation and glucose control. It suggests that future treatments for type 2 diabetes may be developed to replicate these surgical metabolic effects without requiring invasive procedures.

With prolonged use of these shorts, it has been observed that they can prevent and treat health issues such as infl...
18/07/2025

With prolonged use of these shorts, it has been observed that they can prevent and treat health issues such as inflammation, cellulite, swollen lymph nodes, edema, gynecological conditions, and even help prevent cervical cancer.

G’day everyone,Over the past few decades, I’ve spent much of my career looking at the link between obesity and type 2 di...
18/07/2025

G’day everyone,
Over the past few decades, I’ve spent much of my career looking at the link between obesity and type 2 diabetes β€” and the real-life ways we can turn things around.
A while back, we ran a randomised controlled trial here in Melbourne comparing two approaches for people recently diagnosed with type 2 diabetes:
1️⃣ Traditional lifestyle and medication
2️⃣ Laparoscopic adjustable gastric banding (or β€œlap-band” surgery)
The results were nothing short of remarkable. After two years:
βœ”οΈ 73% of those who had the surgery went into full diabetes remission – meaning normal blood sugar levels without needing meds.
βœ”οΈ In the lifestyle group? Just 13% achieved remission.
βœ”οΈ On average, the surgical group lost over 20% of their body weight.
We weren’t surprised to see better blood glucose numbers, less insulin resistance, and fewer needing diabetes meds. What did surprise us was just how strongly weight loss itself predicted diabetes remission β€” not necessarily the method, but the amount of weight lost.
πŸ’‘ In fact, if someone dropped more than 10% of their body weight, their chances of remission skyrocketed β€” no matter their age, s*x, or starting weight.
🧠 So what’s the take-home message?
For people living with obesity and early-stage type 2 diabetes, meaningful weight loss β€” especially through surgery β€” may offer a real chance at remission, not just better control.
This isn’t about vanity or quick fixes. It's about evidence-based medicine and giving people back their quality of life.
We still need larger and longer-term studies β€” but these results were a powerful wake-up call: maybe it’s time we start thinking about weight loss surgery as a front-line therapy, not a last resort.
Kind regards,
Prof. John B. Dixon
MBBS, PhD, FRACGP
Monash University | Centre for Obesity Research & Education
Melbourne, Australia πŸ‡¦πŸ‡Ί
πŸ“Œ If you or someone you care about is struggling with type 2 diabetes and weight, have a chat with your GP. There are more options today than ever before.
🩺 Feel free to share this post if it resonates with you β€” let’s get the facts out there.

🧬 Weight Loss and Inflammation: A Hidden Health BonusObesity is not just about extra weight β€” it’s a chronic low-grade i...
18/07/2025

🧬 Weight Loss and Inflammation: A Hidden Health Bonus
Obesity is not just about extra weight β€” it’s a chronic low-grade inflammatory condition.
πŸ“Š In a study of 477 patients tracked over 2 years, we found that losing weight significantly reduced white blood cell (WBC) counts β€” a clear signal that the body’s inflammation was decreasing.
πŸ”¬ Results after 2 years:
Average weight loss: 29.3 kg
Total WBC count ↓ 12.2%
Neutrophils ↓ 11.7%
Lymphocytes ↓ 6.9%
(All statistically significant, P < 0.001)
These white blood cells are biomarkers of systemic inflammation, and their reduction reflects a shift toward better immune health.
πŸ“‰ The higher the starting weight, the greater the drop in WBCs.
The change in BMI was the strongest independent predictor of how much inflammation improved.
πŸ’‘ While age, gender, insulin, and triglycerides had small effects on baseline WBC counts, together they explained less than 10% of the variance.
🧠 Bottom line: Sustainable weight loss not only lowers your body weight β€” it also calms the immune system, reduces inflammation, and improves metabolic health in a measurable way.

πŸ’¬ What’s Keeping You Up and Reaching for the Fridge at Midnight? Let’s Talk About Night Eating Syndrome (NES).Night Eati...
18/07/2025

πŸ’¬ What’s Keeping You Up and Reaching for the Fridge at Midnight? Let’s Talk About Night Eating Syndrome (NES).
Night Eating Syndrome (NES) isn’t just about the occasional late-night snack β€” it’s a real, diagnosable condition that may contribute to obesity and binge eating.
In our study of over 400 participants, 11% met the criteria for NES. That means:
They weren’t hungry in the morning,
Ate more than half their daily calories after 7pm, and
Struggled with sleep at least 3 nights a week.
We found that NES was significantly linked with:
Higher body mass index (BMI),
Binge eating disorder (BED),
And, interestingly, being male.
But here’s the kicker: psychological distress (like depression and poor mental health) was only really a problem in those who woke up during the night to snack. These β€œnocturnal snackers” had:
Worse mental health-related quality of life,
Greater depressive symptoms,
And higher hunger levels.
πŸ‘‰ In short: if you’re struggling with poor sleep and find yourself eating late at night or even waking up to eat, you’re not alone β€” but it might be time to dig deeper. Night eating might not just be a habit β€” it could be a signal your body and mind are trying to tell you something.
Let’s start listening. πŸ§ πŸ½οΈπŸŒ™

In My Opinion: "Obesity Is Not Your Fault" β€” Debunking the Myth of Quick-Fix Weight LossObesity Is Not Your FaultFirst a...
18/07/2025

In My Opinion: "Obesity Is Not Your Fault" β€” Debunking the Myth of Quick-Fix Weight Loss
Obesity Is Not Your Fault
First and foremost, I want to stress that obesity is not a matter of personal failure. It's not simply about willpower or a lack of self-control. The truth is, there are numerous factors at play, including genetics, hormonal imbalances, environmental influences, and lifestyle habits. In modern society, many individuals are faced with circumstances that contribute to weight gain, often outside of their control. Obesity is complex, and it’s far from just a matter of eating too much or not exercising enough. "Obesity is the result of many interacting factors, and it's not something that should be blamed on the individual."
The Dangers of Quick-Fix Weight Loss
One of the most damaging myths is the idea of β€œquick-fix” solutions. People often turn to extreme diets or rapid weight loss strategies, hoping to see instant results. However, I’ve seen time and time again that these methods are not only ineffective in the long term, but they also harm the body. Rapid weight loss leads to muscle loss, slows down metabolism, and can cause nutritional deficiencies. "These drastic measures may give you temporary results, but they can also lead to a dangerous cycle of weight gain and loss, which can harm your health in the long run."
The Importance of Scientific Treatment
What’s crucial, however, is that weight loss should be approached scientifically. GLP-1 therapies, such as Semaglutide, are evidence-backed treatments that help regulate metabolism, control appetite, and assist in sustained, healthy weight loss. I firmly believe that scientific treatments should be at the forefront of obesity management. "These treatments provide a much-needed solution for those struggling with obesity, allowing them to address the underlying metabolic issues and achieve sustainable weight loss without resorting to extreme diets."
The Role of Lifestyle and Behavioral Support
While medications like GLP-1 are invaluable tools, they’re not a magic bullet. Lifestyle changesβ€”such as adopting a balanced diet, increasing physical activity, and addressing emotional and psychological factorsβ€”are integral to successful weight management. "Weight loss is not just about taking a pill; it’s about making sustainable changes to your lifestyle. The combination of scientific treatments and lifestyle support offers the best path to long-term success."

✨ Happy CRNA Week! ✨This week, we celebrate the amazing Certified Registered Nurse Anesthetists (CRNAs) who play a criti...
18/07/2025

✨ Happy CRNA Week! ✨
This week, we celebrate the amazing Certified Registered Nurse Anesthetists (CRNAs) who play a critical role in ensuring patient safety and comfort during surgeries and procedures.
Thank you for your dedication, expertise, and compassion in providing anesthesia care that helps countless patients each day! πŸ’™

When the body needs energy, fats are broken down into fatty acids and glycerin, which are then circulated and utilized b...
18/07/2025

When the body needs energy, fats are broken down into fatty acids and glycerin, which are then circulated and utilized by muscles and other tissues. When the body takes in more energy than it expends, the excess energy is converted into fat and stored in fat cells, leading to weight gain and fat deposits. In women, an increase in abdominal fat can be observed as they age, even without weight gain. This phenomenon may be attributed to reduced blood circulation and a slowing metabolism, which typically accompany the aging process.

Happy International Volunteer Day!Today, we celebrate the incredible impact our volunteers makeβ€”both in big ways and sma...
18/07/2025

Happy International Volunteer Day!
Today, we celebrate the incredible impact our volunteers makeβ€”both in big ways and small. Whether it's supporting those living with diabetes, raising awareness, or advocating for better care and policies, each volunteer plays a vital role in creating a world free of the effects of diabetes.
Thank you to our dedicated volunteers for your time, passion, and heart. Together, we can drive change, spread hope, and create a brighter future for those affected by diabetes.

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