20/01/2025
Thank you to Dr Carolyn Lister who explains how twins are contributing to better understanding of multiple sclerosis: "Multiple sclerosis (MS) is a neurodegenerative disorder caused by the immune system mistakenly attacking the myelin sheath, a protective coating around nerve fibres. This results in inflammation, which further damages the myelin sheath, as well as the nerve cells themselves and the cells that produce myelin.
"Research has shown that if one twin has MS, the identical sibling has a 25% risk of also developing the condition during his or her lifetime. Scientists can leverage this and examine data from the seemingly healthy twin who may already have some very early signs of MS.
"Researchers have identified a population of immune cells whose early activation and migration into the brain might contribute to MS onset. Ultimately, the scientists believe their findings position CD8 T-cells as a promising therapeutic target for slowing MS progression. They could also be used to facilitate early disease detection, allowing treatment to start before significant nervous system damage has accumulated." Synopsis by Dr Carolyn Lister, International Council of Multiple Birth Organisations (ICOMBO)
A study involving identical twins suggests alterations in immune cells called CD8 T-cells may be early drivers of inflammation in MS.