Crusade Against Kidney Disease

04/09/2024

Fix Your Gut, Save Your Kidneys

Your gut health plays a crucial role in supporting kidney function. In our latest blog post, we dive into how fixing your gut can lead to improved kidney health and reduced inflammation.

Discover the foods and supplements that work wonders for your kidneys

- https://crusadekidneydisease.com/the-connection-between-gut-health-and-kidney-disease/

- https://crusadekidneydisease.com/bifidobacterium-in-kidney-disease-and-other-human-diseases/

04/09/2024

What’s your go-to natural remedy for supporting your kidneys?

Share your tips with us below — let's build a community of health warriors!

26/05/2022

In 1991, Serge Renaud, a scientist from Bordeaux university introduced a term called “French Paradox”. It’s about a contradictory observation that French people have a relatively low incidence of coronary heart disease (CHD), while having a diet relatively rich in saturated fats in apparent contradiction to the widely held belief that the high consumption of such fats is a risk factor for CHD. Several attributes of French Lifestyle and Diet have been analysed.

But one specific compound often found in red wine (especially red wine prepared from grapes of the Bordeaux region or other regions with comparable climatic conditions) attracted the attention of many researchers. It’s called Resveratrol (It's Nitric-Oxide-inducing compound and also necessary to potentiate activity of active Vitamin D / Calcitriol to activate VDR with multiple actions from blood-pressure to anti-inflammatory activities)

Resveratrol, which is part of a categories of molecules known as Sirtuins (7 varieties, i.e. SIRT1-SIRT7), has been found to play a key role in cellular ageing, mitochondrial health and chronic kidney disease (CKD) which is often associated with accelerated ageing.

SIRT1 enzyme plays an important role in cellular response to Calorie-Restriction (CR; fasting) amongst other stressors. So much so that it’s often called a CR-mimetic. Whenever you fast or visit a sauna, your body up-regulates SIRT1’s expression at cellular level which is one of the many reasons fasting and sauna have been held at high regard for longevity in traditional medicine practiced over thousands of years. So fasting is generally good for CKD, when done with careful monitoring, esp. around electrolytes (potassium, phosphorus etc.)

With regard to the kidney, SIRT1 reduces albuminuria (protein leakage in urine), reduces blood pressure and related cardiovascular diseases, resists acute kidney injury, delays kidney fibrogenesis, promotes cyst formation and benefits renal ageing

To know about amazing sirtuins & their role in chronic kidney disease (CKD), please refer to the chapter "The Wine Factor" from my book "Crusade Against Kidney Disease"

http://getbook.at/ckd

12/02/2022

29/12/2021

We all love pomegranates. Besides its antioxidant load (anthocyanins, polyphenols, ellagitannins etc), our omnipotent can convert constituent ellagitannins to magical (and therapeutic) compounds such as Urolithin A, Urolithin A and Isourolithins.

is not only powerhouse (batteries) to our cells, they play a key role in almost all degenerative diseases and ageing, including chronic (CKD) which usually has fewer treatment options in our traditional medical system. Although mitochondria are found in high volume in all metabolically-active organs such as Brain, Heart, Liver etc, Heart & Kidney having higher resting-state energy demand, are particularly sensitive to any mitochondrial dysfunction.

Scientists have recently discovered that Urolithin A induces "mitophagy" - a key metabolic process that recycles old and dysfunctional mitochondria, causing production of fresh new mitochondria (mitochondrial biogenesis). Mitophagy is like a housekeeping (Autophagy for mitochondria) activity, necessary for efficient maintenance of cellular systems.

https://www.nature.com/articles/nm.4132
>> Ryu, D. et al. Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents. Nat. Med. 22, 879–888 (2016)

However, only 40% of us can naturally convert Urolithins from dietary ellagitannins at meaningful levels, due to wide variance across our . This is where modern comes into play. Through cutting-edge A company has created a bio-absorbable Urolithins product.

NOTE: Urolithins have very high No-Observed-Adverse-Effect-Level (NOAEL)

/ approaches are best for all forms of chronic degenerative diseases such as CKD, while avoiding toxic side-effects of many medicines.

More such anti-ageing (and CKD-related) stories can be found at https://crusadekidneydisease.com/