05/06/2024                                                                            
                                    
                                                                            
                                            NEW! BIOBLUE PBM PEN IS HERE..
Photobiomodulation therapy with Blue Light
Blue light is primarily absorbed at the first complex of the Respiratory Chain i.e. NADH and recent laboratory studies have demonstrated that 405nm enhances chondrogenesis and osteogenesis, and suppresses adipogenesis in precursor or stromal cells (Kushibiki, T et al. 2013).
Stromal cells are a heterogenous class of connective tissue cells residing within the living matrix, that are capable of building the infrastructure of any organ, because parenchymal cells- that define the specific function of an organ, are also embedded in the Stromal cell  framework .
As well as their important role in organ genesis, they also fulfill a variety of fundamental roles in disease and health.
405nm blue light has been found to exert antimicrobial effects against a variety of bacteria, including Methicillin-Resistant Staphylococcus Aureus (MRSA) in vitro (Enwemeka, C.S et al. 2020).
Endogenous bacterial chromophores eg. Porphyrins, NADH, Flavins and other photosensitive receptors, can be triggered by blue light to produce Reactive Oxygen Species (ROS) which control several biological processes, such as inflammation, proliferation and cell death. Although ROS consists of a range of oxidising molecules that can damage cells, they also play a key role in intracellular signalling and transcription factors that influence cellular behaviour and gene expression, and essential for a range of biological functions, including cell survival and immune response (Hamblin, M.R. et al. 2005).
REFERENCES
Enwemeka, C.S., Bumah, V.V. & Masson-Meyers, D.S. (2020) Light as a potential treatment for pandemic coronavirus infections: A perspective. Journal of Photochemistry& Photobiology, B:Biology 207, May 2020.
Kushibiki, T., Hirasawa, T., Okawa, S. & Ishihara, M. (2013) Blue Laser Irradiation Generates Intracellular Reactive Oxygen Species in Various Types of Cells. Photomedicine and Laser Surgery Vol 31:3 pp95-105, Mary Ann Liebert, Inc.