
19/07/2025
Citrulline Malate is one of those misunderstood and often overlooked and underrated but effective amino's. This meta-analysis looked at all the studies assessing the impact of citrulline malate supplementation on strength endurance/reps to failure during resistance training.
Compared to placebo, Citrulline malate led to small but statistically significant benefits for reps to failure on lower-body, upper-body, and overall strength. It therefore can delay fatigue and enhance muscle endurance during high-intensity strength training. Best results were seen in fatigue resistance exercise, making it ideal for hypertrophy or volume-based training. Typical best protocol was 6–8 g Citrulline Malate 1 hour before exercise.
The mechanism by which Citrulline malate works is that it supports ammonia and lactic acid clearance, improving muscle endurance. It also boosts nitric oxide for vasodilation leading to better oxygen and nutrient delivery.
Here's the study: https://pubmed.ncbi.nlm.nih.gov/34010809/