07/07/2025
We may soon have a vaccine that protects against cavities, especially in children. Researchers have developed a nanoparticle-based formulation that targets Streptococcus mutans, the bacteria most responsible for tooth decay.
Instead of traditional methods like fluoride or sealants, this vaccine uses PLGA nanoparticles to deliver bacterial antigens and stimulate the body’s own immune system. It boosts IgA antibodies in saliva (our natural first line of defense in the mouth) and IgG antibodies in the blood, helping stop bacteria before they ever form plaque.
This could change pediatric preventive dentistry — imagine fewer restorations, less chair time, and long-term caries protection starting from a single childhood injection.
