Short Cases on Clinical Neurology

26/08/2025

*Correlation of Migraine and stroke :*

A migraine with a stroke, known as *migrainous* *infarction* , is a rare ischemic stroke that occurs during a migraine with aura, where the aura symptoms are prolonged and a brain scan shows brain damage.

While *migraines with aura* are associated with a higher risk of stroke, especially in young women, this is a rare event, not a common cause-and-effect relationship.

21/08/2025

*CGRP's Role in Migraine:*
CGRP is a neuropeptide that is released during a migraine attack. It *contributes to the dilation of blood vessels in the head, a process that can contribute to migraine pain.* Additionally, CGRP is involved in transmitting pain signals from the trigeminal nerve to the brain, further exacerbating the pain.

Calcitonin gene-related peptide-targeted therapy in migraine: current role and future perspectives - The Lancet

Almost 40 years ago, the discovery of the vasoactive neuropeptide calcitonin gene-related peptide (CGRP) and its role in migraine pathophysiology ushered in a new era in migraine treatment. Since 2018, monoclonal antibodies (mAbs) targeting the CGRP pathway are available for migraine prevention. The...

18/08/2025

New test detects motor neurone disease before symptoms:

**How the Aptamer-Based Test Works:
*Aptamers* :**

The new test uses aptamers, which are short, synthetic DNA or RNA molecules that can bind to specific target molecules.
*Targeting TDP-43:*
In this case, the aptamer is designed to target a protein called TDP-43, which is known to clump together in the brains of people with MND.
*Early Detection* :
The aptamer can detect these clumps in brain tissue samples, even at very low levels and with greater accuracy than current methods like antibody tests.
*Pre-Symptomatic Detection:*
This allows for the detection of MND before the onset of symptoms, when cells are beginning to malfunction.

17/08/2025

**Stem cell therapy for* *MS*
Stem cell therapy for multiple sclerosis (MS) is an experimental treatment aimed at resetting the immune system to reduce attacks on the central nervous system. It involves using stem cells, typically from the patient's own body, to rebuild the immune system and potentially slow or stop MS progression. While promising, it's not a cure and carries risks.
Stem cell therapy for MS

Stem cell therapies are being explored as a potential way to address the need for more effective treatments for MS.

12/08/2025

*New treatment addresses multiple aspects of MND*
Motor neurone disease, which affects over 5,000 people in the *UK* at any given time, is characterised by progressive muscle wasting.

Current treatments only address symptoms, but *Ellorarxine* shows potential to tackle the underlying causes of the disease.

The study revealed that Ellorarxine demonstrates antioxidant and anti-inflammatory effects, even at very low concentrations.

It was found to increase the expression of key proteins, promote neurite growth, and improve mitochondrial health – all crucial factors in combating MND.

What sets Ellorarxine apart is its ability to address what researchers call the "3Ns" – neuroprotection, neuroplasticity, and neurorepair. This comprehensive approach is rare in potential MND treatments and could be a game-changer in the field.
Source: A study by Durham University

09/01/2025

Short Cases In Clinical Neurology 3rd edition....

12/05/2024

Alhamdulliah. My textbook on " Short Cases in Clinical Neurology - 3rd Edition " has been published today. Now available : Contact, Shamim Khan +880 1737-655852 and +8801711180902 (Whatapps).

09/01/2024

https://youtu.be/FmEgcud1AlA?si=Sakaq_hMtoGHj2ZC

23/06/2023

My 3rd text book on Neurology " Fundamentals in Clinical Neurology ".