21/08/2025
Rutinib Cream (Ruxolitinib) for the treatment of Alopecia Areata. is being actively studied and used off-label for Alopecia Areata, particularly for milder, patchy cases. Active Ingredient: , Generic Name: ™, Brand Name: .
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How It Works for Alopecia Areata
Areata (AA) is an autoimmune disease where the body's immune system attacks the hair follicles, causing hair loss.
· The JAK Pathway: This attack is driven by inflammatory signals that travel through the Janus Kinase (JAK) pathway inside immune cells.
· The Inhibitor: Ruxolitinib is a JAK inhibitor. When applied topically, it works locally in the skin to block the JAK-STAT pathway, effectively "calming" the immune attack on the hair follicles.
· The Goal: By reducing inflammation around and within the follicle, the drug allows the follicle to recover and re-enter the growth (anagen) phase, leading to hair regrowth.
Rutinib (Ruxolitinib) Cream is FDA-approved for the topical treatment of non-segmental vitiligo in adults and children 12 years of age and older.