Keto Kitchen

06/05/2025

Interesting ready for expecting moms 🌸

A recent study in Nature Metabolism highlights how maternal exercise during pregnancy can improve offspring metabolic health through a mechanism involving the adipokine SERPINA3C. These findings provide valuable insights into how early-life metabolic programming occurs and may offer new approaches for preventing obesity and metabolic disorders.

The research shows that maternal physical activity increases SERPINA3C production in white adipose tissue (WAT), which is then transferred into fetal circulation. Once in the fetus, this protein influences fat cell development by enhancing expression of Kruppel-like factor 4 (KLF4), a transcription factor that regulates inflammation and metabolic balance. By increasing KLF4 levels, maternal exercise protects offspring from diet-induced obesity, insulin resistance, and chronic inflammation, even when they are later exposed to a high-fat diet (HFD).

To confirm the role of SERPINA3C, researchers conducted both knockdown and overexpression experiments. When maternal SERPINA3C was reduced, offspring exhibited higher fat accumulation, increased adipose inflammation, and impaired glucose metabolism. Conversely, artificially increasing SERPINA3C levels in maternal WAT replicated the metabolic benefits of maternal exercise in offspring, even in the absence of physical activity.

SERPINA3C activates the cathepsin G-integrin β1-PI3K pathway, which triggers epigenetic modifications in fetal fat cells. It promotes the removal of methyl groups from the Klf4 gene, sustaining its expression and preventing adipose inflammation.

These findings highlight the influence of maternal health on offspring well-being. Engaging in regular physical activity during pregnancy not only benefits the mother but can also provide lasting metabolic advantages for her child. Understanding these mechanisms could also inform early-life interventions aimed at reducing the risk of obesity, diabetes, and other metabolic diseases. As research continues to uncover the biological pathways connecting maternal lifestyle to offspring health, there is more potential for strategies that center upon metabolic health.

Read the study here: https://www.nature.com/articles/s42255-024-01213-6

06/05/2025

How fun does this sound? 😊😀

🍬 Save the Date: The Great Candy Run 5K is back on Sunday, Nov. 9, 2025! 🍭

The sweetest race of the year supports families facing fetal health diagnoses — and every step makes a difference. 💙

🏃‍♀️ Join us in Colorado or virtually
💝 Not running? Donate and still make an impact

Every step — and every dollar — brings us closer to stronger beginnings and brighter futures for families everywhere.

06/05/2025

Need to register

Join us to learn more about epilepsy in the workplace, your rights and reasonable accommodation by employers for employees with epilepsy. Our dynamic panel will unpack these issues with their experience, expertise and insight for a truly educational webinar not to be missed by workers and employers....

03/18/2025

Another epilepsy study is looking for participants aged 12 and up. Participants who suffer prolonged seizures are the ideal candidates.

Clinical Trial Opportunity:
UCB Biopharma is conducting a phase 3 clinical trial called STARS that is investigating a drug for prolonged (seizures typically lasting more than 3 minutes with a predictable pattern). The study is looking for patients 12 years of age and older who have focal or generalized epilepsy, or a combination of the two. It is required for the patient to have an active caregiver to be part of this study.

For more study information, please contact an experienced Patient Navigator at +1 470-523-2502. The Patient Navigators are healthcare professionals available to help you better understand this clinical study and decide if it may be right for you.

To learn more about the study visit https://www.starsepilepsystudy.com/

03/18/2025

Congrats on getting to a seizure free point!! 🙌😊

A parent's peace of mind when it comes to their child's safety is priceless. We are grateful to all the DDF supporters whose generosity makes it possible to provide detection monitors to families in need. Please read the feedback from one family below:

"I cannot put into words the peace of mind that Danny Did Foundation provided our family. Before we were able to purchase our device, I would stay awake as long as I could at night, terrified our daughter may have a seizure during her sleep and stop breathing. I was crippled by fear that she would experience SUDEP due to the type of seizure she has experienced. This has given her independence back as a young adult who has been able to start her first semester of college, as well as her first job! She has been seizure-free since June, but the lingering fears of a mother have only been calmed due to this potentially life-saving device. Thank you for the incredible gift of funding for devices that we could not have been able to provide on our own."

03/18/2025

We are proudly Canadian at Keto Kitchen but we also love and support our American neighbors who are suffering at the hands of their delusional President.

True North Strong & Free! 🇨🇦 Celebrating the people, places, and spirit that make Canada great!

We share positivity, unity, and pride—always with kindness. No negativity, no profanity—just pure Canadian love. 🍁

🇨🇦🇨🇦JOIN US!! Help spread Canadian pride! 🇨🇦🇨🇦

03/18/2025

Did you know Greece has prioritized wheelchair access at their beaches?



https://accessnow.com/blog/greece-makes-hundreds-of-beaches-wheelchair-accessible/

03/16/2025

Are there any Canadians in this group?

02/24/2022

Does anybody need a seizure watch? We have a first-generation one that I am happy to draw a name for and gift it.... Samsung phone included in the gifting.

Comment here below to enter, and share the post about the "Mee See Tees" funky t-shirts to qualify as an entry.

Will draw a winner in the next 2 weeks :)

02/22/2022

😍😍PROMO CODE: BUY2 for free shipping when you buy any two!😍😍

The CUTEST t-shirts for your little ones! Flippin' fun graphics that your kids see,, not you! PLUS a portion of the proceeds goes to protect, clean, and save our oceans in the Pacific Northwest!

https://www.meeseetees.com/

09/17/2021

Can somebody please explain to me how the science is going to work for long-term studies of Covid vaccines with a proper, scientifically coordinated placebo/control group, if everybody on the planet gets vaccinated?