Combilytics Corp

10/24/2024

DunedinPACE is a epigenetic DNA test that indicates "rate of aging". This is not an indicator of how long you will live but more of a systems overview with respect to healthy aging and expected mortality risks.

The lower the number the better.

We've done 5 tests over nearly 4 years. What we are looking for is a trend over time. Am I trending up or down over time?

Apparently we are doing something that is moving this indicator in the right direction. As of Nov 2024 I'm #140 and Joan Matheson is in the top 50 out of over 3,600 bio-hackers on
https://www.rejuvenationolympics.com/dunedin-pace

Plus all the ones ahead of us are younger. Which is a factor due to how we age in phases (32 and 60 are the known shift points in aging).

Are you keeping up with the youngsters these days? :-)

08/19/2024

Fat Steve, 61y/o - 2017 - a lifetime of struggle.

Ripped Steve, 68y/o - 2024 - looking to live a healthier lifestyle to enjoy our grandkids 🙂

They say it's never too late, not sure about that but gonna push on through till the end anyway 🙂

www.combilytics.com

07/18/2024

Rapamycin - first molecule to extend lifespan in every species it's been tested in.

Can it extend human lifespan?

While that is a great goal, my question would be can it increase health span? and it appears it does.

We added this to our longevity protocols over a year ago. And yes we have noticed benefits.

Study Enrolment Link Here: https://www.aotearoatrials.nz/enrolling-studies #!/study/1786For weekly health research summaries and extra sights, sign up here 👉...

07/11/2024

Joan and I have been working on our health span and life span. As part of that we have both had 4 Dunedin Pace tests done as part of the complete DNA methylation comprehensive test.

If you don't measure it, you can't manage it.

Joan is on the Leaderboard with a best Pace of 0.74 at position 16 for best Pace. Hundreds of bio-hackers have entered these Olympics and of those Joan is in the top 20.

I'm rooting for her to get in the top 10 at her next test in September 2024.

If you want to be like Joan and slow your aging significantly, let me know.

Here is the site so you can check out who is ahead of her and who is behind. Many have spent 10's of thousands, 1 has spent over $2M a year trying to slow, stop and even reverse aging.

https://www.rejuvenationolympics.com/dunedin-pace

06/13/2024

Processed foods are a headline for a reason. Processed foods are harmful to us and are the leading cause of many of modern humanities health issues, from CVD, to Cancer, from metabolic diseases to neurological conditions.

When "fake meat", i.e. plant based "meat" hit the market, the first thing I did was look at how it's made and what goes into it. I was shocked at the various harmful compounds used in creating these supposedly "healthy" products.

The vegan hype train was the access point for these harmful "foods". So many people bought into this concept and companies made millions selling this garbage.

Don't get me wrong, a truly plant based diet can be very healthy, but not if it includes processed foods.

The dietary contribution of plant-sourced non-UPF inversely linked to CVD risk, while plant-sourced UPF contribution showed a positive association. Recognizing the role of food processing is crucial for favourable CVD outcomes, even in plant-sourced diets.

05/13/2024

"Plant butter" is nothing more than highly processed "food" don't be fooled by the corporate double speak.

I'll stick to real butter :-)

55% modified palm and palm kernel oil, 24% canola oil, water, salt, pea protein, soy lecithin, citric acid, natural flavour, beta carotene,
Calcium Disodium EDTA

04/18/2024

The future of aging looks expensive!!

🙃

04/10/2024

So many people think va**ng is "safe". Our lungs were never designed to take the abuse of any inhaled foreign substances.

Key points summary of Sky News article. Study finds concerning similarities in DNA damage between va**rs and smokers

03/13/2024

Our company founder Steve Matheson and his wife Joan have been working for 4 years at improving their age related markers with a variety of interventions.

The first project in 2020 was killing but that is not the be all and end all of their interventions. It is something they do in 1 month cycles and have completed 4 cycles per year for the past 4 years.

While cells are one of the top 3 of the 12 Hallmarks of Aging and have a predominantly negative effect on 7 of the other Hallmarks, it is not the complete answer to the longevity puzzle. There is no one and done, there is no single silver bullet for the complex nature of aging. So the quest continued for answers, which expanded the level and types of interventions.

October of 2022 every 2 weeks at a dose of 6mg was added

Jan 2023 was added to their program and the length increases are quite impressive in their last 2 tests.

July 2023 a well thought out program started and provided additional benefits.

January of 2024 several other additions have been made to their longevity stack. Those will be discussed in October of 2024 when the next test results are available.

They use www.trudiagnostic.com as their testing platform as this company is pushing the boundaries of what can be tested and evaluated. As one of the few DNA testing labs doing foundational research with the top research organizations in the world, they should be on your list for testing.

Steve and Joan shortened the time between tests from annual to every 9 months so they could more closely iterate what works (for them) from what doesn't and from these latest test results, they are continuing to move the needle back in a wide variety of markers.

Joan's results are posted here, interestingly Joan's results are far better than Steve's.

https://www.dropbox.com/scl/fi/aahdz25btwgzkman80ub5/JOAN_Trudiagnostic_Summary_4-tests_21-to-24.pdf?rlkey=h1aqp3ksv91q91yzm9n4trqpe&dl=0

02/16/2024

Some interesting personal test results.

Joan and I have been using our formula for nearly 4 years now and we have been getting annual epigenetic DNA methylation tests done. We now have results from 3 tests over the past 2 years. We are changing our testing cycle to every 9 months so we can more quickly respond to both positive and negative changes. We submitted our most recent samples Jan 2024 to a company I trust for DNAm testing.

Note the bump up in 2022. Our annual test was 3 months after we both had Covid. I expected it would go up then as Covid is a pro-aging infection and generates senescent cells.

Every time one becomes infected it causes accelerated aging.

COVID-19 and cellular senescence
https://www.nature.com/articles/s41577-022-00785-2

Because Covid accelerates aging (one of the many harmful things it does), we started a cycle of EternLFX the week after the infection.

Our product, EternLFX moved our markers (3 cycles over 7 months after Covid) in the right direction as measured 9 months after the infection.

So far everyone who has done the 3 cycle, 7 month evaluation protocol, testing before and after with TruDiagnostic has shown significant improvement in the majority of their aging markers.

02/08/2024

is a hard road for parents, their children, teens and adult people on the spectrum.

Here is something that may help.

Some info on sulforaphane.

https://www.pnas.org/doi/full/10.1073/pnas.1416940111

In a placebo-controlled, randomized, double-blind clinical trial, daily oral administration for 18 wk of the phytochemical sulforaphane (derived from broccoli sprouts) to 29 young men with ASD substantially (and reversibly) improved behavior compared with 15 placebo recipients. Behavior was quantified by both parents/caregivers and physicians by three widely accepted measures. Sulforaphane, which showed negligible toxicity, was selected because it upregulates genes that protect aerobic cells against oxidative stress, inflammation, and DNA-damage, all of which are prominent and possibly mechanistic characteristics of ASD.

This is where we get it. I'd suggest not changing brands.

https://ca.iherb.com/pr/swanson-sulforaphane-from-broccoli-sprout-extract-400-mcg-60-veggie-caps/118029
They are often out of stock but you can get in the notification list and as soon as you are notified place the order.

It's as close to a miraculous turnaround as you will ever see. Our little 4 y/o guy talks more than ever.. He is engaged, looks directly in the eye now, will try to catch when you toss him something and often does catch it!, he would never do any of these things a month ago. Also he was having a hard time with his bowel movements, he is now regular and it causes him no distress.

One capsule dissolved in his water, a sippy cup that he usually has finished in the morning and he has a couple more glasses during the day, without the sulforaphane. It's basically tasteless and he doesn't even know it's there..

Brands A-Z Swanson Categories Supplements Greens & Superfoods Greens Broccoli Save 20% in cart Ends: March 6, 2024 at 10:00 AM PT. Discount applied in cart. May not be combined with other offers. Autoship & Save Special Swanson, Sulforaphane from Broccoli Sprout Extract, 400 mcg, 60 Veggie Caps By S...

01/18/2024

I was recently reminded of the significant amount of BS advice that is available on the inter webs. Raech Geneva Rose thanks Raech!!

How does the average Joe/Jane deal with all the potentially bad info and people/grifters offering advice?

Since I'm not educated in the field of bio-science, I recognize that my own weakness and biases could easily lead me astray.

How can one move forward? who should I listen to?

I "follow" more than a few of the top researchers in the areas of bio-science, often related to longevity. With longevity it's also important to understand a bit about diseases caused by a variety of pathogens. I also follow top medial specialists, board certified in their specialty. You don't ask a Cardiologist for help with a viral infection, you go to a Virologist or Infectious Disease Dr..

One of the many good people I pay attention to is Matt Healy a Computational Biologist at Enveda Biosciences.
https://www.linkedin.com/in/matthewdhealy/

One of his recent posts outlines a process anyone can follow if they are looking for "truth" as opposed to finding info that confirms their biases.

And I quote;

"Here are a few criteria by which I evaluate sources about COVID. Some of these criteria require that you have relevant expertise but some can be applied by any person:
- 1. Has the source published articles or posts whose details indicate the author has actual technical expertise and isn't using big words without understanding them.
- 2. Has the source published articles or posts in which the author clearly states what the author DOES NOT KNOW; a crucial aspect of true expertise is knowing one's limitations.
- 3. Has the source or the author published anything about the subject at hand BEFORE THE SUBJECT HAD A HIGH PROFILE IN THE NEWS; for instance has the author written about Ukraine before Russia invaded that country or written about Infectious Disease Research before 2020.
- 4. Do other highly credible sources cite other publications or posts by the author.
- 5. If the source is a non-specialist news organization, how has the source handled stories on other topics about which you have actual expertise.
- 6. Does this source have a detectable agenda such as a political viewpoint, commercial interest."

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