Carbon 60 hydrated fullerenes reference page

05/13/2025

10/30/2021

Are increased levels of systemic oxidative stress and inflammation associated with age-related cataract?
Antioxid Redox Signal. 2014 Aug 10;21(5):700-4. doi: 10.1089/ars.2014.5853. Epub 2014 Mar 14.
Selin JZ1, Lindblad BE, Rautiainen S, Michaëlsson K, Morgenstern R, Bottai M, Basu S, Wolk A.
Author information
• 11 Division of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet , Stockholm, Sweden .

Abstract
Oxidative stress and inflammation may be involved in the etiology of age-related cataract. This study is the first to investigate the association between urinary levels of 8-iso-prostaglandin F₂α (PGF₂α; as a biomarker for systemic oxidative stress in vivo) and 15-keto-dihydro-PGF₂α (as a biomarker for systemic inflammation in vivo) and risk of age-related cataract. We observed in a nested case-control study, including 258 women with incident cataract diagnosis and/or cataract extraction and 258 women without cataract, matched on age and date of urine sample collection that, women with higher levels of urinary 8-iso-PGF₂α as compared with lower levels had an increased risk of age-related cataract. There was no difference in 15-keto-dihydro-PGF₂α levels between cases and controls. Our observations lead to the hypothesis that higher systemic oxidative stress increases the risk of developing age-related cataract.

10/25/2021

Pharmacological Applications of Antioxidants: Lights and Shadows.
Curr Drug Targets. 2014 Oct 24. [Epub ahead of print]
Saso L, Firuzi O1.

Abstract

Oxidative stress is linked with many pathologies ranging from cancer to neurodegenerative diseases and antioxidants are presumably of therapeutic value in such diseases. In this review, we categorize different direct and indirect mechanisms by which antioxidants exert their action, including scavenging and metal chelating effects, mimicking the antioxidant enzymes or upregulation of their expression, activation of nuclear factor erythroid 2-related factor 2 (Nrf2), increasing the activity of sirtuins and inhibition of pro-oxidant enzymes among others. Recent findings on the most frequently investigated antioxidants including polyphenolics, thiolics, spin trapping agents, SOD mimetics, inducers of heme oxygenase-1 and nitric oxide synthase, activators of Nrf2, NADPH oxidase inhibitors and herbal supplements are also summarized. Furthermore, the antioxidant effects of drugs that are clinically used for other pharmacological purposes including ACE inhibitors and statins are discussed. Cost-effectiveness and adverse effects of antioxidants are also evaluated. Since antioxidant therapy has failed in many instances, we have classified the reasons that may explain these shortcomings in different categories. Novel approaches to antioxidant therapy that include mitochondria-targeting drugs, antioxidant gene therapy and approaches for improvement of cell uptake and alteration of subcellular compartment localization are also described. In the end, "shadows" that are shortcomings of antioxidant therapy as well as "lights" that include positive outcomes are addressed. It is concluded that if we learn from failures, invest on agents with higher potential and take advantage of novel emerging approaches, antioxidants could be an asset for the management of some of the carefully chosen oxidative stress-related diseases.

10/25/2021

[N.B. C60-HYFNs regulates proper protein folding-WD]

Proteasome activation delays aging in vitro and in vivo.
Free Radic Biol Med. 2014 Jun;71:303-20. doi: 10.1016/j.freeradbiomed.2014.03.031. Epub 2014 Mar 27.
Chondrogianni N1, Sakellari M2, Lefaki M3, Papaevgeniou N3, Gonos ES2.
Author information
• 1National Hellenic Research Foundation, Institute of Biology, Medicinal Chemistry, and Biotechnology, 116 35 Athens, Greece. Electronic address: nikichon@eie.gr.
• 2National Hellenic Research Foundation, Institute of Biology, Medicinal Chemistry, and Biotechnology, 116 35 Athens, Greece; Örebro University Medical School, Örebro, Sweden.
• 3National Hellenic Research Foundation, Institute of Biology, Medicinal Chemistry, and Biotechnology, 116 35 Athens, Greece.
Abstract
Aging is a natural biological process that is characterized by a progressive accumulation of macromolecular damage. In the proteome, aging is accompanied by decreased protein homeostasis and function of the major cellular proteolytic systems, leading to the accumulation of unfolded, misfolded, or aggregated proteins. In particular, the proteasome is responsible for the removal of normal as well as damaged or misfolded proteins. Extensive work during the past several years has clearly demonstrated that proteasome activation by either genetic means or use of compounds significantly retards aging. Importantly, this represents a common feature across evolution, thereby suggesting proteasome activation to be an evolutionarily conserved mechanism of aging and longevity regulation. This review article reports on the means of function of these proteasome activators and how they regulate aging in various species.
Copyright © 2014 Elsevier Inc. All rights reserved.
KEYWORDS:
Aging; Free radicals; Longevity regulation; Proteasome activation; Senescence; Ubiquitin–proteasome system

10/23/2021

Pancreatic Cancer, Free Radicals (Oxidative Stress) and Carbon 60 Hydrated Fullerenes from Kharkiv, Ukraine

Oxidative stress and cytokines in the pathogenesis of pancreatic cancer.
J Cancer Prev. 2014 Jun;19(2):97-102. doi: 10.15430/JCP.2014.19.2.97.
Yu JH1, Kim H2.
Author information
• 1New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu, Korea.
• 2Department of Food and Nutrition, Brain Korea 21 PLUS Project, College of Human Ecology, Yonsei University, Seoul, Korea.
Abstract
Pancreatic cancer is one of the most aggressive, drug-resistant and lethal types of cancer with poor prognosis. Various factors including reactive oxygen species, cytokines, growth factors, and extracellular matrix proteins are reported to be involved in the development of pancreatic cancer. However, the pathogenesis of pancreatic cancer has not been completely elucidated. Oxidative stress has been shown to contribute to the development of pancreatic cancer. Evidences supporting the role of reactive oxygen species and cytokines as a risk for pancreatic cancer and the concept of antioxidant supplementation as a preventive approach for pancreatic cancer have been proposed. Here, we review the literature on oxidative stress, cytokine expression, inflammatory signaling, and natural antioxidant supplementation in relation to pancreatic cancer.
KEYWORDS:
Cytokines; Oxidative stress; Pancreatic cancer

Carbon 60 Hydrated Fullerenes and Cancer
Multiple medical & biological properties: http://www.ipacom.com/index.php/en/fullerenes-and-water-left/74

Having conducting large-scale research, we already knew the following main biological and medical properties of hydrated C60 fullerene (C60HyFn) by the end of 2005.

Simultaneously with research at the molecular and cell level, experiments in vivo (with laboratory animals) have revealed that C60HyFn in wide scale of C60 total dose (from ultra small and up to 25 mg/kg of body weight):

- Has a positive influence on antioxidant systems;

- Has radioprotective properties due to the inhibition of the excessive level of free radicals;

- Inhibits the development of tumour pathologies without killing cancer cells;


Nowadays, on the basis of a complex analysis of numerous experimental facts, official bio-medical trials, and our own observations, we have arrived at the conclusion that water solutions of hydrated fullerene C60 have a broad and universal spectrum of positive biological activity. In particular, they:

- Shorten the period required for the organism to recover after surgeries;

- In the case of preventive intake, decrease the probability of developing oncological pathologies, and in the case if one has already developed and depending on its stage of development, help the organism to inhibit, restrain and control its spread. In addition to independent use, they are potent additional agents in combined, rational therapy of oncological conditions;

- Significantly prolong the period of remission in patients after surgically removing a tumour neoplasm and decrease the risk of relapse of an active tumour process;

- Promote a reduction in side effects caused by the use of active antitumor chemotherapy (improve its tolerance);

- Are radioprotectors and their administration is quite grounded for eliminating the side effects of radiation therapy;

July 11, 2011, site updated and presentation Hydrated fullerene: some most important physical-chemical and biological properties now is available.

07/08/2021

Antibacterial & antiviral properties of Carbon 60 hydrated fullerenes

Proposal for Health Canada, Ministry of Health and the FDA( Medicalcountermeasures.gov )
to consider Carbon 60 hydrated fullerenes, a natural organic, as an antiviral therapy for COVID_19 patients, since it’s safe, nontoxic and already on the market for 10 years with no side effects and contra-indications. It could be accelerated into stage 2B randomized double blind trials.

✅ Business Case for pristine Carbon 60 hydrated fullerenes (C60HyFns) as 1) an antiviral for , 2) an anti inflammation and 3) antibacterial for secondary infections, such as pneumonia

✅ Fullerenes, are an all-carbon, organic product found in nature, hence they are registered as a dietary supplement, and not a drug

✅ Carbon 60 hydrated fullerenes, the water-soluble version of Carbon 60, was discovered by Ukrainian scientist Dr. Grigoriy Andrievsky, in the early 19990s in Ukraine.

(PDF) Factsheet #7 Backgrounder on Carbon 60 Hydrated Fullerenes - ResearchGate
https://www.researchgate.net/publication/277292896_Factsheet_7_Backgrounder_on_Carbon_60_Hydrated_Fullerenes

✅ Carbon 60 hydrated fullerenes (C60HyFns) were approved as a ultra high antioxidant & dietary supplement in 2010, by the Ukrainian Ministry of Health, after safety, preclinical and human clinical trials and after issuing a Safety & Health certificate by the Ministry of Health of Ukraine no. 05.03.02-04/95179, which was issued on December 2, 2010.
http://www.ipacom.com/images/Articles/c60water1.pdf

✅ CLINICAL AND PRE-CLINICAL STUDIES

Safety Studies

Investigation of the Specific Activity and Toxic Action of Water Solution of Hydrated C60 Fullerene (C60FWS) Report of the Laboratory of Morphofunctional Research, National Pharmaceutical University MHU, Kharkov, Ukraine, 2009, 68 p., (Abstract).

Study of the Probable Genotoxic Action of Hydrated C60 Fullerenes (C60HyFn) in the form of Water Solution (C60FWS)
Report of the Laboratory of Radiation Cytogenetics, State Institute of Medical Radiology AMSU, Kharkov, Ukraine, 2010, 19 p. (in Russ).

Clinical Studies

Efficacy of Fullerene (C60) Application in Complex Therapy of Patients with Ulcerative Disease
Report of the 3-d Department of Internal Medicine, Kharkov National Medical University, Kharkov, Ukraine, 2009, 33 с., (Abstract).

Efficacy of Application of The Biologically Active Supplement “Water solution of Hydrated C60 Fullerene” in Complex Therapy of Patients with Chronic Hepatitis if Toxic Genesis
Report of the 3-d Department of Internal Medicine, Kharkov National Medical University, Kharkov, Ukraine, 2009, 37 p., (Abstract).

Pre-Clinical Studies

Investigation of the Specific Activity and Toxic Action of Water Solution of Hydrated C60 Fullerenes (C60FWS) . Report of the Laboratory of Morphofunctional Research, National Pharmaceutical University MHU, Kharkov, Ukraine, 2009, 68 p., (Abstract).

✅ after 11 years on the Ukrainian market, since 2010, there are no reported side effects and contraindications.

✅preclinical & clinical trials also show that C60HyFns increase the bio activity & bioavailability of co-medications, so it could be used as an adjuvant with existing treatments

✅ Aqueous solutions of pristine C60 hydrated fullerene or their derivatives/ analogues have been show to suppresses 🚫 hepatitis C virus 🚫 Influenza A (H1N1) virus 🚫 herpes simplex virus HSV 🚫cytomegalovirus infections, 🚫 HIV 🚫 retrovirus and others.
Google: Pubmed, fullerenes, antiviral

⚠️ N.B. Researchers from around the world are experimenting with fullerenes derivatives because pristine fullerenes exhibit extremely low solubility in water. Only Ukrainian scientists have discovered how to make fullerenes water-soluble, creating safe, nontoxic Carbon 60 hydrated fullerenes or C60HyFns. 💦

⚠️Carbon 60 hydrated fullerenes and fullerenols are two non-related and separate molecules. Carbon 60 hydrated fullerenes are safe and nontoxic at the nano level, whereas fullerenols are toxic.

⚠️ 🛑 Fullerenol nanoparticles: toxicity and antioxidant activity.
Methods Mol Biol. 2013;1028:75-100. doi: 10.1007/978-1-62703-475-3_5.

✅ Fullerenes as anti inflammatory agents

✅ Carbon 60 hydrated fullerenes were shown to be anti inflammatory agents in preclinical and clinical trials

✅ It would be interesting to explore if fullerenes reduce COVID_19 virulence by inhibiting NLRP3 inflammasomes to stop the perpetuation of cytokine storms in the lungs

✅ Fullerenes as antivirals & antibacterials

✅ Bilateral intersticial pneumonia in the lungs is usually cause of death, with COVID_19

✅ ANTIVIRAL - A clinical trial in Ukraine showed that pristine Carbon 60 hydrated fullerenes positively acted again Hepititis C viral infection, actling as an antiviral and a liver protector.( hepatoprotector)
http://www.ipacom.com/images/Articles/report_clinical_hepatitis_en.pdf

✅ ANTIBACTERIAL - A clinical trial in Ukraine showed that pristine Carbon 60 hydrated fullerenes positively acted again Helicobacter pylori (H. pylori) a bacteria that causes stomach ulcers, acting as an anti-bacterial.
http://www.ipacom.com/images/Articles/results_trials_en.pdf

✅Fullerenes act as an Universal antibacterial, by hampering 1) “quorum sensing” between bacteria, which is the communication signalling process between normally latent, quiet , benign bacteria, before they go “pathogenic” in your body, such as bacertial pneumonia and in 2) “biofilm” formation by bacteria in your organs or on biomedical devices.

✅ Fullerenes act as a “Universal” antiviral by blocking viral replication by inhibiting the 1) viral replicase, 2) viral protease, 3) reverse transcriptase, 4) RNA polymerase and 5 endonuclease enzymes

✅ Fullerenes have been shown to be antiviral by computer simulations showing molecular docking simulation mechanisms.
Example: Docking simulation of C 60 fullerene with influenza PA endonuclease.

✅ example: Anti-Influenza Activity of C60 Fullerene Derivatives
PLOS One 2013, 8(6)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3681905/

✅ example: Compounds with anti-influenza activity: present and future of strategies for the optimal treatment and management of influenza Part II: Future compounds against influenza virus - NCBI - NIH
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4718316/

✅ example: Effect of fullerene C60-polyvinilpyrrolidone complexes on influenza virus reproduction.

✅ example: Medicinal applications of fullerenes, Int J Nanomedicine. 2007;2(4):639-49.
https://www.ncbi.nlm.nih.gov/pubmed/18203430

✅ Functional Carbon Quantum Dots as Medical Countermeasures to Human Coronavirus | ACS Applied Materials & Interfaces - ACS Publications - American Chemical Society
Oct. 21, 2019 · Therapeutic options for the highly pathogenic human coronavirus (HCoV) infections are urgently needed. ... In this work, the antiviral activity of seven different carbon quantum dots (CQDs) for the treatment of human coronavirus HCoV-229E infections was investigated.

✅ Human immunodeficiency virus-reverse transcriptase inhibition and hepatitis C virus RNA-dependent RNA polymerase inhibition activities of fullerene derivatives. Bioorg Med Chem Lett. 2005 Feb 15;15(4):1107-9
Mashino T1, Shimotohno K, Ikegami N, Nishikawa D, Okuda K, Takahashi K, Nakamura S, Mochizuki M.

✅ Cytotoxic and antiviral properties of fullerene C60 in the culture of animal cells
Zinaida Klestova, Dr., Ph.D.*, Yuriy Prylutskiy, Dr., Ph.D.,** Marina Marchenko Ph.D. Student ***
*State Scientific-Control Institute of Biotechnology and Strains of Microorganisms (Donetskaya St, 30,Kyiv-151, Ukraine);
**National Taras Shevchenko National University of Kyiv, Volodymyrska Str. 64, 01601 Kyiv, Ukraine
***The Institute of Veterinary Medicine of NAAS (Donetskaya St. 30, Kyiv-151, Ukraine)

✅ Knocking Out Viral Infections With Fullerene
NEWS Sep 24, 2019 | Original story from the Skoltech Center for Energy Science and Technology

Fullerenes have attracted considerable attention in different fields of science since their discovery in 1985. Investigations of physical, chemical and biological properties of fullerenes have yielded promising information. It is inferred that size, hydrophobicity, three-dimensionality and electroni...

06/15/2021

From 2014

Innovative Fullerene-Based C-60 Products

The unique properties of fullerene water allow it to be the basis for creating innovative products in the fields of medicine, pharmacology, food industry, agriculture, veterinary medicine, cosmetics and the production of organic and inorganic applications, wherever water is used to create products.

The scientific and clinical research conducted made it possible to secure permission, for the first time anywhere in the world, to manufacture and sell fullerene water solutions (FWS) in Ukraine. The Ministry of Health of Ukraine approved the industrial use of these solutions as an antioxidant in food, perfumery and cosmetics, biotechnology and microbiology in 2010. The product sells successfully on the world market. It is undergoing official certification in Russia, Belarus, Kazakhstan, the countries of Latin America and China. North America is next.

Innovative foods and drinks may be created based on FWS. The first product based on fullerene solutions was fullerene water under the C60Water of Life® brand. The Ministry of Health of Ukraine recommends its use as a daily dietary supplement. No other known medicinal water has the multidimensional systemic effect on the living organism similar to that of water containing carbon molecules. Doctors at spa resorts with natural fullerene water recommend drinking medicinal waters straight from the pump, as they lose their properties a few hours later. Fullerene water however can be stored for years and its curative properties do not only no dissipate, but actually intensify.
The second product is the "Krina" dietary supplement, providing real help in the treatment of diseases of the liver, and stomach and duodenal ulcers.

The third product is potable fullerene water for active people with a very good brand.

With FWS deliveries, fullerene water can be manufactured in any country of the world. For example, one liter of FWS 144 concentrate is sufficient to produce 72 tons of the dietary supplement or 720 tons of potable fullerene water.

06/15/2021

Fullerenes and prevention of atherosclerosis-preclinical studies

Water and carbon are the basis of the human body. The human body is 55% to 78% water, depending on age and health status. The status and structure of this water affects the proper function of all of the body's biological structures. Fullerene water affects all of the water in the human body, renewing and restoring it.

The antiatherogenic properties of fullerene water have been studied under the experimental atherosclerosis model at the L.T. Malaya Therapeutic Institute of the Ukrainian Academy of Medical Sciences. Adding large doses of cholesterol to the diet of experimental animals caused an experimental pathology with a characteristic set of atherosclerotic lesions of the liver, kidneys, spleen and blood vessels of the heart (extensive cholesterol plaque throughout the aorta). Further, without altering the diet, researchers added intravenous injections of fullerene water on a schedule of 1 injection every 2 weeks. A total of 4 injections were made over the course of 2 months. As a result, the arterial plaque of the heart was almost completely cleared and the atherosclerotic lesions in the liver, kidney and spleen eliminated. Researchers continued to give the animals large doses of cholesterol, maintaining it at a level in the blood above the norm. Nevertheless, under the influence of fullerene water, the cholesterol did not "take root" on the walls of the blood vessels, and was eliminated from the body without any harmful effects.

Source: Innovative products based on aqueous solutions of hydrated fullerene C60.

06/15/2021

Fullerenes and anti-tumor effects in prostate cancer and ovarian cysts -preclinical studies

Water and carbon are the basis of the human body. The human body is 55% to 78% water, depending on age and health status. The status and structure of this water affects the proper function of all of the body's biological structures. Fullerene water affects all of the water in the human body, renewing and restoring it.

Research at the N.N. Blokhin Russian Oncology Research Center at the Russian Academy of Medical Sciences studied the effects of fullerene water on the growth of ovarian cysts and prostate cancer in mice and rats. The water was found to have an anti-tumor effect. The application of fullerene water resulted in inhibition of tumor growth by 30-70%. Furthermore, life expectancy was extended by 1.5-2 times. Moreover, in animals that drank the fullerene water, inhibition of growth of tumors was higher than that for animals injected with fullerene water.

Source: Innovative products based on aqueous solutions of hydrated fullerene C60.

06/14/2021

Why all antioxidants are not made the same...Most botanical antioxidants/supplements are degraded /metabolized by gut bacteria and bacteria your saliva, therefore of little practical value. Carbon-60 or hydrated fullerenes -the highest anti-oxidant in the world are not metabolized by bacteria. That's why in vivo tests(in the body) and in vitro tests (in the lab) may not produce the same results or often conflicting results for many botanicals--Walter Derzko
Some Health Benefits Of Berries May Not Make It Past Your Mouth
COLUMBUS, Ohio – Research has suggested that compounds that give colorful fruits their rich hues, especially berries, promote health and might even prevent cancer. But for the first time, scientists have exposed extracts from numerous berries high in those pigments to human saliva to see just what kinds of health-promoting substances are likely to survive and be produced in the mouth.
It’s too early to name the best berry for health promotion based on this initial work. But the researchers have discovered that two families of pigments that provide berries with their colors, called anthocyanins, are more susceptible to degradation in the mouth than are the other four classes of these pigments.
The Ohio State University study also showed that bacteria living in the mouth are responsible for most of the breakdown of these compounds that occurs in saliva. Researchers are investigating whether it’s the berry pigments themselves, or instead the products of their degradation, that actually promote health.

Scientists say that these early findings will contribute to the further development of confectionaries, gums and other delivery devices for the prevention and possibly the treatment of conditions such as periodontal disease and oral cancers.
The researchers exposed extracts of anthocyanin pigments from blueberries, chokeberries, black raspberries, red grapes and strawberries to the saliva collected from 14 people. Black raspberries, in particular, have been shown in numerous previous studies to have chemopreventive effects on tumors in the mouth, esophagus and colon, mostly in animal studies. Their high anthocyanin content has been linked to those benefits.
“All fruits are unique because their chemical composition, or fingerprint, varies,” said Mark Failla, professor of human nutrition at Ohio State and interim chair of the Department of Human Sciences. “There are many different edible berries. Some might be better for providing health-promoting effects within the oral cavity, whereas others may be more beneficial for colonic health. We simply do not know at this time.
“Increased intake of fruits and vegetables is associated with decreased risk of some chronic diseases. An understanding of the metabolism of these compounds, and the relative activities of the compounds in the consumed fruit and their metabolic products, is needed to make scientifically sound dietary recommendations and to develop effective delivery vehicles for the mouth,” Failla said.
The research is published in a recent issue of the journal Food Chemistry.
Failla and colleagues asked 14 healthy individuals between the ages of 21 and 55 years to collect saliva in the morning before they had eaten breakfast or brushed their teeth. Research participants later collected additional saliva samples before and after they had rinsed their mouths with an antibacterial liquid.
The five fruits selected for study allowed the scientists to test the six distinct families of the anthocyanin pigments. Researchers purified the anthocyanins from each berry type and added the extracts to saliva.
The extent of the pigment degradation in saliva was primarily a function of the chemical structure of a given anthocyanin, said Failla, also an investigator in Ohio State’s Comprehensive Cancer Center and Food Innovation Center.
Two families of anthocyanins consistently degraded when exposed to saliva: delphinidin and petunidin. Four other families were more stable: cyanidin, pelargonidin, peonidin and malvidin.
“Our observations suggest that the bacteria within one’s oral cavity are a primary mediator of pigment metabolism. The bacteria are converting compounds that are present in the foods into metabolites,” Failla said. “One area of great interest is whether the health-promoting benefits associated with eating anthocyanin-rich fruits like berries are provided by the pigment itself, the natural combinations of the pigments in the fruit, or the metabolites produced by bacteria in the mouth and other regions of the gastrointestinal tract.”

________________________________________
“There are many different edible berries. Some might be better for providing health-promoting effects within the oral cavity, whereas others may be more beneficial for colonic health.”
________________________________________

There is context for this study that further complicates the understanding of anthocyanins’ benefits. Multiple studies have led to the conclusion that anthocyanins themselves are very poorly absorbed by the body.
“If anthocyanins are the actual health-promoting compound, you would want to design food products, confectionaries and gels containing mixtures of anthocyanins that are stable in the mouth. If, on the other hand, the metabolites produced by the metabolism of anthocyanins are the actual health-promoting compounds, there will be greater interest in fruits that contain anthocyanins that are less stable in the oral cavity,” Failla said. “We lack such insights at this time.”
The extent to which the anthocyanins were degraded varied among the 14 people whose saliva was used in the study. However, two families of anthocyanins consistently degraded the most in all volunteers. Failla said the observed variation among individuals is likely related to differences in the microbial community that resides in each person’s mouth.
This research group is continuing the work, examining which bacteria are most involved in the metabolism of anthocyanins and testing the stability of the pigments in berry juices in the mouths of human volunteers rather than in test tubes containing their saliva.
This work was supported in part by the Ohio Agricultural Research and Development Center.
Co-authors include Kom Kamonpatana of the Interdisciplinary Ph.D. Program in Nutrition; Monica Giusti and Ken Riedl of the Department of Food Science and Technology; Chureeporn Chitchumroonchokchai of the Department of Human Nutrition; and Maria MorenoCruz and Purnima Kumar of the Department of Periodontology, all at Ohio State. All but MorenoCruz are also investigators in the Food Innovation Center.
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06/12/2021

https://www.researchgate.net/profile/Urol-Makhmanov/publication/346920988_Self-aggregation_of_C60_particles_in_a_volume_of_evaporating_droplets_on_a_flat_surface/links/605dc7f8299bf173676c4b7f/Self-aggregation-of-C60-particles-in-a-volume-of-evaporating-droplets-on-a-flat-surface.pdf?origin=homeFeed_download&_iepl%5BactivityId%5D=1354129595318272&_iepl%5BactivityTimestamp%5D=1617290854&_iepl%5BactivityType%5D=person_like_publication&_iepl%5Bcontexts%5D%5B0%5D=homeFeed&_iepl%5BrecommendationActualVariant%5D=&_iepl%5BrecommendationDomain%5D=&_iepl%5BrecommendationScore%5D=&_iepl%5BrecommendationTargetActivityCombination%5D=&_iepl%5BrecommendationType%5D=&_iepl%5BfeedVisitIdentifier%5D=&_iepl%5BpositionInFeed%5D=10&_iepl%5BsingleItemViewId%5D=YleYvQBOf0iUvYK4gjKxvi4d&_iepl%5BviewId%5D=1vWY2CLpvQ5umfrSgZcLYUTc&_iepl%5BhomeFeedVariantCode%5D=ncls&_iepl%5B__typename%5D=HomeFeedTrackingPayload&_iepl%5BinteractionType%5D=publicationDownload&_iepl%5BtargetEntityId%5D=PB%3A346920988

06/10/2021

Fullerenes-C60 in cosmetics

Recent Pat Biotechnol. 2009;3(2):118-23.
Use of fullerenes in cosmetics.
Lens M.
King's College, Genetic Epidemiology Unit, St. Thomas's Hospital, Lambeth Palace Road, London, UK. markolens@aol.com

Abstract
As cosmetic technology advances, there is an increasing need to use new active ingredients in the development of cosmetic products. In the last few years application of fullerene C(60) and its derivatives in cosmetics has been intensively tested. Fullerenes display a wide range of biological activities. Potent scavenging capacities against radical oxygen species (ROS) and excellent potential as biological antioxidants made fullerenes suitable active compounds in the preparation of skin rejuvenation cosmetic formulations. Currently published evidence on biological activities of fullerenes relevant for their cosmetic use and examples of published patents to illustrate application of fullerenes in cosmetic technology are presented. Future trends in the development of cosmetic formulations including fullerenes are discussed.
PMID:
19519567
[PubMed - indexed for MEDLINE]