Nicolien Janssen Hypermobility Syndrome Symptom relieve with supplements

09/11/2025

Tooth now removed, because the inflammation did not subside. After a week now it looks like the inflammation is under control, but the wound still has to heal.

31/10/2025

IBS-D/BAD: So everything is back to normal now, I can eat everything again, though I go easy on the cheese and calcium containing foods. For everybody with diarhea type IBS; Calcium is exitory, hence the irritability (without infection) and magnesium is inhibitory. I was so low on magnesium, that I would get muscle twitches in the night. Magnesium gets resorbed in the ileum, which is th last part of the small intestine. B12 and bile should also be (re)absorbed here and this is also impaired. (See other posts from dr William Wallace) The absorption of these three is impaired, because the valve to the colon is wide open. I already took B12 under the tongue and this is how i came upon the idea to take the magnesium under the tongue. The magnesium threonate tastes slightly bitter. I think one could also take magnesiumglycinate, but take a chelated good absorbable form.

25/10/2025

William Wallace, Ph.D
Product Development, Scientific Affairs, and Regulatory Compliance Dietary Supplements, Ingredients and Health Education.

Here’s the shortcut to how your body actually gets B12 from food in 7️⃣ steps:

1️⃣ Starts in Food
Meat, eggs, dairy, fish → B12 is protein-bound.
💡 Example: That salmon fillet carries B12, but it’s locked up tight.

2️⃣ Stomach Acid Breaks It Free
Gastric acid + pepsin release B12 from food proteins.
💡 Without stomach acid (think antacids or age-related decline), B12 release suffers.

3️⃣ Haptocorrin (HC) Grabs It First
In the stomach, B12 binds to HC (a protective chaperone).
💡 This shields B12 from the harsh acidic environment.

4️⃣ Intrinsic Factor (IF) Takes Over
In the small intestine, enzymes break HC → B12 rebinds to IF (made by stomach cells).
💡 No IF = no absorption (that’s what happens in pernicious anemia).

5️⃣ Absorption in the Ileum
The B12–IF complex docks on special receptors (Cubam) in the ileum.
💡 That’s why B12 deficiency can occur after ileum surgery or Crohn’s disease.

6️⃣ Transport in Bloodstream
Once inside, B12 switches to transcobalamin (TC), the form cells can use.
💡 B12 + TC = delivery service to tissues and mitochondria.

7️⃣ Cellular Activation
Inside cells, B12 converts to active forms:

Methylcobalamin → makes methionine (DNA + neurotransmitters).

Adenosylcobalamin → runs mitochondria (energy).
💡 No active B12 = fatigue, neuropathy, brain fog.

23/10/2025

Since two days I am taking the magnesium Threonate/Magtein under the tongue and finally my body absorbs it. My stools are now OK and I had a bearnaise sauce today, a little on my meat, which I did not react to. Also had no muscle twitches in the night anymore. My digestive system relaxes. Also had porridge with milk which went well.

17/10/2025

How magnesium balance goes wrong

Magnesium is a key electrolyte for nerve signaling, muscle contraction, and heart rhythm. Because it regulates over 300 enzymatic reactions, both low and high magnesium levels can disrupt nearly every system in the body. This diagram shows how magnesium metabolism becomes deranged through dietary deficits, renal loss, or metabolic disease.

1️⃣ When magnesium supply is low
Poor intake, malabsorption, or chronic diarrhea reduce magnesium absorption from the gut.
🟢 Example: Long-term proton pump inhibitor use or celiac disease can cause gradual depletion and low serum magnesium.

2️⃣ Renal magnesium loss
The kidneys fine-tune magnesium reabsorption, but several conditions—such as loop diuretics, alcoholism, hyperaldosteronism, or Bartter’s syndrome—increase urinary loss.
🟢 Example: Loop diuretics (like furosemide) block magnesium and calcium reabsorption in the nephron, leading to hypomagnesemia.

3️⃣ Cellular uptake and insulin
Insulin helps drive magnesium into cells, so insulin deficiency or resistance (as in diabetes mellitus) causes extracellular buildup and intracellular depletion.
🟢 Example: In type 2 diabetes, magnesium inside muscle cells falls while serum levels appear normal, contributing to fatigue and insulin resistance.

4️⃣ Hypomagnesemia (low magnesium)
Chronic loss lowers magnesium in blood and tissues, increasing neuronal excitability.
🟢 Symptoms: Tachycardia, arrhythmias, cramps, tremors, depression, and reduced parathyroid hormone (PTH) release, which in turn lowers calcium.

5️⃣ Hypermagnesemia (high magnesium)
Usually occurs from renal failure or excessive magnesium intake (e.g., antacids or laxatives) when the kidneys cannot excrete it efficiently.
🟢 Symptoms: Muscle weakness, low reflexes, constipation, vomiting, hypotension, and in severe cases, respiratory arrest or cardiac arrhythmia.

6️⃣ Bidirectional relationship with calcium and potassium
Magnesium deficiency disrupts calcium and potassium transport—lowering both and amplifying muscle irritability and arrhythmia risk.
🟢 Example: Restoring magnesium is often the first step before potassium can be normalized.

Magnesium’s balance depends on diet, kidneys, and hormonal control. Too little excites the nervous system; too much suppresses it. The result is a tight physiological window where even small shifts in magnesium can alter the rhythm, reflex, and stability of the entire body.

16/10/2025

The "periodic table of vitamins" explained simply

We all know vitamins and minerals matter, but keeping track of which ones do what can feel like chemistry class. Here’s an attempt at the plain-English version:

1️⃣ Vitamins = Activators
They turn enzymes and reactions on, making energy, neurotransmitters, and hormones possible.
💡 Example: B12 and folate drive methylation, critical for DNA repair and brain function.

2️⃣ Minerals = Spark Plugs
Minerals act like cofactors that help enzymes run.
💡 Example: Magnesium is needed in more than 300 reactions, from ATP production to muscle relaxation.

3️⃣ Antioxidants = Shields
They neutralize free radicals that damage cells.
💡 Example: Vitamin C recycles Vitamin E, while CoQ10 protects mitochondria.

4️⃣ It’s a Network, Not Solo Players
These nutrients recycle and regenerate each other. One deficiency can drag the whole system down.
💡 Example: Without selenium, glutathione can’t work; without B2, folate can’t activate.

5️⃣ Food Sources Matter Most
Vitamins and minerals don’t float alone. They come packaged with synergistic compounds in real food.
💡 Example: Eggs give you choline + B12 + selenium, a combination you’ll never get from an isolated pill.

Think of your nutrients like a periodic table. Each one has a role, but together they form the chemistry of life. Focus on variety in whole foods, not just single “hero” supplements.

15/10/2025

Methylation is your body's on/off switch for health

Methylation is how your body moves tiny chemical tags (methyl groups, “CH₃”) onto DNA, proteins, and neurotransmitters. It’s like flipping switches that control mood, energy, detox, and gene expression.

🔹 The Two Primary Cycles

Folate Cycle: Folate (B9) is converted into methyl-folate, the form that can donate methyl groups. This depends on enzymes like MTHFR, and cofactors such as B2, B3, and B6.
💡 Example: People with MTHFR variants may need methyl-folate supplements because they convert folic acid less efficiently.

Methionine Cycle: Methionine (from protein) is turned into SAMe — the body’s “methyl donor.” SAMe hands off methyl groups to hundreds of reactions, from neurotransmitter balance to DNA repair.
💡 Example: SAMe is sometimes prescribed in Europe as a mood support supplement because of its role in serotonin and dopamine metabolism.

🔹 The Recycling Link
Folate and methionine cycles connect through B12 and zinc, which help transfer methyl groups from folate into the methionine cycle.
💡 Example: If B12 is low, homocysteine builds up — a lab marker often linked to cardiovascular risk.

🔹 Cofactors Matter

B vitamins (B2, B6, B9, B12): Run the cycles.

Magnesium & ATP: Provide energy for the reactions.

Zinc & Selenium: Help enzymes work and support antioxidant defenses.
💡 Example: Magnesium deficiency can slow methylation even if folate and B12 intake are adequate.

🔹 Why It Matters

Efficient methylation = steady neurotransmitters, healthy detox, stable DNA, resilience against stress.

Blocked methylation = fatigue, mood changes, high homocysteine, poor detox.
💡 Example: This is why “methylated” B vitamins (methylfolate, methylcobalamin) are included in many advanced supplements.

Methylation isn’t one reaction - it’s a nutrient-driven relay between folate and methionine cycles. With enough B vitamins, magnesium, zinc, and methyl donors, your body keeps the switches flipped in the right direction.

13/10/2025

Thats why I take my olive oil. I take two tablespoons a day. It ramps up DAO enzym, which helps process histamin from food sources in the gut

https://amzns.store/0dsg

13/10/2025

Science is accumulating evidence to suggest that we age through changes in the gut microbiome across different life stages. For example, we know that women going through menopause have less microbial diversity and less short-chain fatty acids (SCFAs), which have implications for body systems like muscle and brain. Therefore, when tending to the later years and optimizing health span, it is crucial to consider both the quantity and quality of the gut microbiome.

Here's a new review article which goes into more detail: Tseng CH, Wu CY. From dysbiosis to longevity: a narrative review into the gut microbiome's impact on aging. J Biomed Sci. 2025 Oct 11;32(1):93. doi: 10.1186/s12929-025-01179-x. PMID: 41076537.

13/10/2025

NORMAL STOOL TODAY🚽😀🎉🥳 Sleap also well😴 Can titrate Niacin/vitamin B3, take extra everytime stool gets loose or worse green. Take at least 2000 mg before bed:

Get the scoop on antihyperlipidemic drugs that help you reach your cholesterol number goals.

13/10/2025

So making delicious veggi soups now, very simple; 1 kg veggies or mushrooms or so with 1 liter of bouillon, boil 15-20 minutes, then blend, add spices you like

13/10/2025

I really needed lots and lots of magnesium and was wondering why, then I read this article again, which says magnesium is also a cofactor for making bile: https://www.researchgate.net/profile/Patrick-Chambers-4/publication/385732071_Magnesium_and_Longevity/links/6733003169c07a411444fa29/Magnesium-and-Longevity.pdf?origin=publication_detail&_tp=eyJjb250ZXh0Ijp7ImZpcnN0UGFnZSI6InB1YmxpY2F0aW9uIiwicGFnZSI6InB1YmxpY2F0aW9uRG93bmxvYWQiLCJwcmV2aW91c1BhZ2UiOiJwdWJsaWNhdGlvbiJ9fQ&__cf_chl_tk=ZNNyL_ZDQmy4nyjSYh2GMd0b0vUdoNUTFjzeiR4i5wA-1760252549-1.0.1.1-FTijAwAPgF._bDEL6BM6C678GXePaKpJibgl9hjthmk But it also reminded me about the calcium/magnesium ration and so I decided I would leave out calcium for a while.