BGI Group

BGI Group BGI was founded privately in 1999 to participate in the renowned Human Genome Project.

BGI Group, a pioneer in life sciences, is one of the world’s leading biotechnology organizations with operations covering research, production, and applications in more than 100 countries and regions. It expanded scope through news business since 2007 and now it supports the genomics-related project with customers across the world.

BGI Group made a strong impact at the 3rd China International Supply Chain Expo, showcasing cutting-edge innovations in ...
16/07/2025

BGI Group made a strong impact at the 3rd China International Supply Chain Expo, showcasing cutting-edge innovations in genomics, health management, and sustainable agriculture. From AI-driven health platforms to agricultural breakthroughs, BGI's technologies are making precision health and food security more accessible worldwide.

Beijing, July 16 – BGI Group made a resounding impact at the third China International Supply Chain Expo (CISCE) this week, unveiling a suite of new technologies and applications designed to advance l...

BGI-Research is advancing brain science through innovation and collaboration. In this interview, BGI scientists shared i...
15/07/2025

BGI-Research is advancing brain science through innovation and collaboration. In this interview, BGI scientists shared insights into their groundbreaking brain mapping studies featured in leading journals. Their research is deepening understanding of neural networks and diseases, shaping the future of neuroscience.

Read: https://en.genomics.cn/en-scientificdiscoverie-7170.html

Unlocking the mysteries of the brain - our most complex and powerful organ - remains one of science’s greatest challenges. Understanding how billions of diverse neurons form networks that enable perce...

Monu Verma believes science should serve people—and through BGI, he’s helping make that happen in India. From driving lo...
14/07/2025

Monu Verma believes science should serve people—and through BGI, he’s helping make that happen in India. From driving local partnerships to transferring NGS lab technology and promoting NIPT (non-invasive prenatal testing), Monu and his team are transforming access to better diagnostics and healthier futures.

By combining BGI’s scientific strength with local care delivery, they’re empowering Indian families to make informed decisions and live healthier, longer lives.

Watch: https://youtu.be/790EraCqot4

Monu Verma believes science should serve people—and through BGI, he’s helping make that happen in India. From driving local partnerships to transferring NGS ...

The Mesoscopic Brain Mapping Consortium is advancing neuroscience with 10 groundbreaking studies and 1 insightful commen...
10/07/2025

The Mesoscopic Brain Mapping Consortium is advancing neuroscience with 10 groundbreaking studies and 1 insightful commentary, published in leading journals of Cell, Neuron, and Developmental Cell. These works represent a significant leap in understanding the brain’s structure, function, and its role in complex diseases.

A major contributor, BGI-Research, co-led 6 pivotal studies, including cover stories in Cell and Neuron:

- Mapping the macaque claustrum (Cell): The first molecular and circuit atlas revealed distinct neuron subtypes integrating brain-wide information, shedding light on cognition and neurological disorders.

- Decoding Alzheimer’s disease (Neuron): Spatial transcriptomics uncovered molecular pathways and cellular changes in the hippocampus, providing targets for diagnostics and therapies.

- Creating the mouse brain atlas (Neuron): Using Stereo-seq, the team identified long non-coding RNAs and their regional roles in brain development and disease.

- Tracing brain cell evolution (Developmental Cell): Comparing brain cell types across species uncovered conserved and species-specific neurons, including bird-specific Purkinje cells.

- Hypothalamic development (Developmental Cell): Cross-species insights revealed human-enriched neurons and evolutionary changes in brain function.

- Intracerebral hemorrhage response (Neuron): Spatiotemporal maps of cellular changes after brain injury offered new therapeutic pathways.

By integrating global collaborations, advanced technologies, and open-access brain databases, BGI-Research is unlocking the brain’s deepest mysteries and paving the way for precision medicine, and transforming neuroscience for science, medicine, and humanity.

Read about these exciting discoveries: https://en.genomics.cn/en-scientificdiscoverie-7168.html

The brain comprises a vast array of neuron types, interconnected in complex networks that underpin functions such as sensory perception, learning, memory, and motor control. Therefore, understanding...

Mark Luo joined BGI with a dream: to make genetic testing more accessible worldwide. From introducing non-invasive prena...
07/07/2025

Mark Luo joined BGI with a dream: to make genetic testing more accessible worldwide. From introducing non-invasive prenatal testing (NIPT) in West Asia to driving local technology transfer and patient awareness, he and his team are advancing healthcare for local communities.

With multi-omics technology and a mission to empower informed health decisions, BGI is helping people live longer, healthier lives.

Watch: https://www.youtube.com/watch?v=SzRomz1HAow

Mark Luo joined BGI with a dream: to make genetic testing more accessible worldwide. From introducing non-invasive prenatal testing (NIPT) in West Asia to dr...

Alzheimer’s affects over 416 million people worldwide, with most in preclinical stages. Despite decades of research, eff...
03/07/2025

Alzheimer’s affects over 416 million people worldwide, with most in preclinical stages. Despite decades of research, effective treatments remain elusive.

Now, BGI-Research has uncovered a critical link: a deficit in indole-3-lactic acid (ILA), an anti-inflammatory compound produced by gut bacteria. This deficit disrupts gut-brain communication, leaving the brain vulnerable to inflammation and damage in early Alzheimer’s.

Using advanced computational tools, scientists identified a targeted synbiotic solution -a combination of the bacterium Lactobacillus suilingensis and the prebiotic inulin - to restore ILA levels. Laboratory studies showed this precision therapy reduced brain inflammation, decreased amyloid plaques, and improved memory in Alzheimer’s-like models.

This discovery could lead to innovative diagnostic markers and preventive interventions for Alzheimer’s, marking a significant step forward in neurodegenerative research.

Read more: https://en.genomics.cn/en-scientificdiscoverie-7167.html

For the estimated 416 million people worldwide on the Alzheimer's disease continuum, including 316 million in preclinical stages, current treatment options remain frustratingly limited. While deca...

Milos Radonjic, a leader of the biomathematical consultancy service team of BGI-Research in Serbia, is guiding a young a...
02/07/2025

Milos Radonjic, a leader of the biomathematical consultancy service team of BGI-Research in Serbia, is guiding a young and dynamic team that supports global clients with cutting-edge tools and experimental technologies.

Driven by the mission to improve human health, Milos is inspired by BGI’s rapid transformation of scientific breakthroughs into real world solutions - from rare disease detection to targeted therapies. His journey, from discovering BGI’s impact during the COVID-19 pandemic to now leading a cross-border, multicultural team, reflects the power of international collaboration in shaping the future of life sciences.



Watch:

Milos Radonjic, as a leader of the biomathematical consultancy service team of BGI-Research in Serbia, is guiding a young and dynamic team that supports glob...

BGI-Research has unveiled a groundbreaking discovery published in Clinical Chemistry. The study reveals that cell-free D...
01/07/2025

BGI-Research has unveiled a groundbreaking discovery published in Clinical Chemistry. The study reveals that cell-free DNA (cfDNA) carries a previously overlooked layer of information: the specific strand of fragmented DNA released from the original double-stranded DNA.

This "strand-specific" signal could improve the precision of liquid biopsies, with potential applications in cancer detection, prenatal care, and more.

Learn more: https://en.genomics.cn/en-scientificdiscoverie-7166.html

For decades, liquid biopsy tests have analyzed the size and positioning of double-stranded cell free DNA (cfDNA) fragments in blood, but they ig-nore the single-stranded fragments that escape conventi...

In a groundbreaking Science study, BGI-Research, the National Institute of Biological Sciences, Beijing (NIBS), and part...
26/06/2025

In a groundbreaking Science study, BGI-Research, the National Institute of Biological Sciences, Beijing (NIBS), and partners, have identified the “missing retinoic-acid switch” that limits regeneration in higher mammals. Using advanced technologies like single-cell sequencing, BGI’s Stereo-seq spatial transcriptomics and 3-D chromatin mapping, the team traced the loss of critical DNA enhancers in rodents that regulate Aldh1a2, the enzyme converting vitamin A into retinoic acid (RA), essential for tissue repair.

By reactivating Aldh1a2 through genetic or pharmacological interventions, researchers restored ear regeneration in mice, including cartilage and nerve growth. RA injections, already FDA-approved for other uses, hold immense therapeutic promise for trauma repair, plastic surgery, and regenerative medicine.

This discovery highlights a molecular pathway conserved across species, offering a potential blueprint for unlocking dormant regenerative programs in humans. All data has been shared publicly, inviting further exploration by the scientific and medical communities.

Read more: https://en.genomics.cn/en-scientificdiscoverie-7165.html

For more than a century, scientists have marveled at the striking disparities in regenerative ability across mammalian species. A rabbit can mend a hole punched clean through its outer ear in about&nb...

On June 26, a collaborative team from BGI-Research, Southern University of Science and Technology, and partners publishe...
26/06/2025

On June 26, a collaborative team from BGI-Research, Southern University of Science and Technology, and partners published a landmark study in Cell, introducing Flysta3D-v2 - a comprehensive 3D single-cell multi-omics atlas covering all stages of fruit fly development.

Leveraging advanced technologies including Stereo-seq, scRNA-seq, and scATAC-seq, the team mapped over 3.8 million spatially resolved single-cell transcriptomes. Flysta3D-v2 reveals unprecedented insights into cell differentiation, tissue morphogenesis, and regulatory networks, providing a powerful reference for developmental biology and disease research.

The atlas and interactive 3D tools are publicly available.

Read the study: https://en.genomics.cn/en-scientificdiscoverie-7164.html

The development of multicellular organisms is an extraordinarily intricate process, orchestrated by the precise interplay of genes and cells across space and time. On June 26, researchers from BG...

Today marks the 25th anniversary of the announcement of the first draft of the human genome—a milestone that changed sci...
26/06/2025

Today marks the 25th anniversary of the announcement of the first draft of the human genome—a milestone that changed science forever. The Human Genome Project united 2,400 scientists across six countries, including BGI from China, to decode 90% of our DNA instructions.

This global collaboration paved the way for breakthroughs in medicine, agriculture, and our understanding of life itself. BGI is proud to have contributed to this historic achievement and will continue advancing genomics.

Here’s to the next 25 years of discovery and innovation!

Learn more: https://en.genomics.cn/en-news-7163.html



Photo caption: The four co-founders of BGI (left to right): Wang Jian, Liu Siqi, Yu Jun, and Yang Huanming, in 1999. BGI was established in 1999 to participate and contribute to the Human Genome Project.

The Human Genome Project (HGP) was undoubtedly the most important biomedical research undertaking of the 20th Century, and arguably of the 21st Century so far, involving 2,400 scientists from six coun...

BGI-Research, in collaboration with Southeast University, has unveiled the world’s first single-cell precision, whole-em...
23/06/2025

BGI-Research, in collaboration with Southeast University, has unveiled the world’s first single-cell precision, whole-embryo digital atlas of the mouse, published in Cell. This groundbreaking study reconstructs early organ development from late gastrulation (E7.5) to early organogenesis (E8.0).

By capturing 104,343 high-quality cells in 3D, this digital embryo offers unparalleled insights into early development, accelerating progress in developmental biology, regenerative medicine, and congenital disease research.

Leveraging BGI's Stereo-seq technology, researchers identified a Primordium Determination Zone (PDZ) - a critical region where heart and gut organ primordia originate. This discovery sheds light on the molecular and cellular mechanisms underpinning organ formation and congenital defects.

Read more about the study: https://en.genomics.cn/en-scientificdiscoverie-7162.html

Early mammalian development unfolds in millimetre-sized embryos within hours, yet errors during this brief window cause nearly a third of all birth defects, from congenital heart disease to neural tub...

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