09/11/2025
๐ง๐ต๐ฒ ๐ฅ๐ผ๐น๐ฒ ๐ผ๐ณ ๐ ๐ฎ๐๐ ๐๐ฒ๐น๐น๐ ๐ถ๐ป ๐๐ต๐ฒ ๐ฃ๐ฎ๐๐ต๐ผ๐ฝ๐ต๐๐๐ถ๐ผ๐น๐ผ๐ด๐ ๐ผ๐ณ ๐๐ต๐ฟ๐ผ๐ป๐ถ๐ฐ ๐ฃ๐ฟ๐๐ฟ๐ถ๐ด๐ผ
๐ ๐ช๐ต๐ฎ๐ ๐ฎ๐ฟ๐ฒ ๐บ๐ฎ๐๐ ๐ฐ๐ฒ๐น๐น๐?
Mast cells are immune cells found in the skin. When they become overactive, they release substances like histamines, cytokines, leukotrienes, and proteases which trigger itch and inflammation.
๐ ๐ช๐ต๐ ๐ฑ๐ผ ๐บ๐ฎ๐๐ ๐ฐ๐ฒ๐น๐น๐ ๐ฝ๐น๐ฎ๐ ๐ฎ ๐ฐ๐ฒ๐ป๐๐ฟ๐ผ๐น ๐ฟ๐ผ๐น๐ฒ ๐ถ๐ป ๐๐ต๐ฟ๐ผ๐ป๐ถ๐ฐ ๐ฃ๐ฟ๐๐ฟ๐ถ๐ด๐ผ?
Mast cells are located close to sensory nerves. When activated, they continuously send signals back and forth, driving the itchโscratch cycle.
Early clinical studies have shown that lowering the number of mast cells in the body can quickly reduce symptoms.
This suggests that new treatments designed to specifically target mast cells โ such as Barzolvolimab โ could be very effective in treating Chronic Prurigo. ๐
Full article is available here: https://doi.org/10.1016/j.jid.2025.09.365