South Sudanese future pharmacists

South Sudanese future pharmacists Our major aim is to brightening the future of upcoming generations.

08/06/2023

Aldosterone antagonists

EXAMPLES
Spironolactone, eplerenone or take a SEAT.

MECHANISM OF ACTION

Competitive antagonist at intracellular aldosterone receptors in
renal tubules causing reduced production of aldosterone-induced proteins. This indirectly
reduces activity of Na */K* ATase in the collecting ducts, increasing excretion of Na* and
decreasing K* loss. Spironolactone, in particular, also acts on receptors in other tissues, including androgen receptors.

INDICATIONS

• Congestive cardiac failure (spironolactone)
• Oedema and ascites in liver disease (spironolactone)
• Post-MI heart failure (eplerenone)
• Nephrotic syndrome (spironolactone)
• Primary hyperaldosteronism (including Conn's syndrome) (spironolactone)

CAUTIONS AND CONTRA- INDICATIONS

• Electrolyte disturbances (including hyperkalaemia and hyponatraemia)
• Caution in renal impairment

SIDE-EFFECTS

• Hyperkalaemia (K* sparing effect)
• GI disturbance
• Anti-androgenic effects (spironolactone - menstrual irregularities in females,
gynaecomastia and hypogonadism in males)

METABOLISM AND HALF-LIFE

Metabolised to active metabolites. ty of drug is 60-90 min
but ty of active metabolites is longer (up to 11 h).

MONITORING

Monitor plasma electrolytes for adverse effects as above.

DRUG INTERACTIONS

• Enhanced hypotensive effect with other antihypertensives
• Increased risk of hyperkalaemia with ACEls/ARBs and amiloride
• Increased risk of nephrotoxicity with NSAIDs

IMPORTANT POINTS

• Eplerenone is more selective than spironolactone and therefore causes fewer s*x hormone-related adverse effects
• Spironolactone may also be used in hypertension (unlicensed indication)

Vein infrared finder.
06/06/2023

Vein infrared finder.

06/06/2023

GERD (Gastroesophageal Reflux Disease) is a condition in which the gastric acid content in the stomach flows back to the oesophagus.

This usually causes a painful burning sensation in the middle of the chest (heartburn).

The Proton Pump Inhibitors (PPIs) are the most effective drugs used for treating GERD.

Examples include Omeprazole, Lansoprazole, Rabeprazole and regularly take 30 or 60 mins before lunch or dinner.

06/06/2023

Cimetidine Vs Ranitidine

Both drugs are used to treat peptic ulcer.
Chronic use of Cimetidine causes the abnormal enlargement of the male breasts (Gynaecomastia)

Ranitidine doesn't

Chronic use of Cimetidine decreases libido and causes impotence in male

Ranitidine doesn't.

04/06/2023
04/06/2023

The day mitochondria went from being "the powerhouse of the cell to the ATP synthesis by oxidative phosphorylation" was a horrible day.

What is an absolute contraindication of ACE inhibitor.
04/06/2023

What is an absolute contraindication of ACE inhibitor.

Hello hearty,love your stuff. I'm a pharmacist who has had addiction issues and I am in recovery but my job options are ...
30/05/2023

Hello hearty,love your stuff. I'm a pharmacist who has had addiction issues and I am in recovery but my job options are limited to say the least. I currently float for WURH and honestly they treat me fairly well. The problem is there aren't many stores close to me and I regularly have 3 or 4 hours a day of driving or hotel stays. I have an offer from CVS that is close with a set schedule. Your disdain for them is clear but do you honestly think that it would be much worse than what l'm doing?

Thanks for any help.

Your thoughts pharmacists.
26/05/2023

Your thoughts pharmacists.

Multivitamins+Minerals (Centrum Advance) is specially formulated to help protect your entire body with a wide range of v...
26/05/2023

Multivitamins+Minerals (Centrum Advance) is specially formulated to help protect your entire body with a wide range of vitamins, minerals, and antioxidants. It applies up-to-date nutritional science to support your health, protecting your heart, eyes, immune system and so much more.
Benefits:
Energy
With B vitamins and folic acid to support energy
Healthy Skin
with vitamin A, vitamin C and biotin to maintain healthy skin.
Immunity
with antioxidants such as vitamins A, C & E, betacarotene, selenium, and zinc to support immune system function.
Muscle Health
Contains vitamin D to support muscle health.

🇸🇸
26/05/2023

🇸🇸

🇸🇸  Drugs expert advice to drug’s users.If you are a single lady, please hear me loud and clear stop taking tablets or i...
23/05/2023

🇸🇸 Drugs expert advice to drug’s users.

If you are a single lady, please hear me loud and clear stop taking tablets or injection to prevent pregnancy, when you are still dating, how could you involve yourself in family planning when you are still single.
Don't you know that family planning is made only for the married couples who are no longer interested in having more kids.
Some ladies always take injection that last 6 months or 1 yr, One thing you don't know about these drugs is that they are only made to kill your eggs and immobilize your hormones and it weakens your circles,
if you would believe with me that since you started taken it, you have noticed that anytime you are to see your me**es, it won't be as regular as it use to be,
sometimes these drugs will hold your menstruation for up to 3 to 4months before it will normalize again,You know exactly what am saying my dear.
I know some ladies may have been living this type of life for over 6 or 10 yrs now.
You are single and in school but you prefer going into family planning when you know you are not married, my dear sister, you are calling yourself into a seriously Barrenness to come and take over your life in the nearest future.
And by that time your chewing gum boyfriend won't be there again for you, by now he will be going home with his new wife and children while you run from pillar to post in search of a child.
Superglue yourself. Even as am writing this now, there are still millions of single ladies who are in the Universities carrying out Family planning ropes inside their womb. Just because you want to be the happening Girl in the campus.
Shame shame shame, such life does not last, am sorry to have exposed you but I have to tell you the truth.
Ladies, protect your eggs, protect your womb and protect your fetus.
Don't be angry and pls don't call me names, because am not feeling fine. but I have said my mind, in as much as I know that Truth is better.

19/05/2023

A 55-year-old man with hypertension and no other chronic medical problems is currently treated with hydrochlorothiazide 50 mg daily, irbesartan 300 mg daily, carvedilol 25 mg twice daily, and amlodipine 10 mg daily. His BP is 144/96 mm Hg (146/94 mm Hg when repeated). He is adherent with all of these medications. Serum creatinine is 1.2 mg/dL, potassium is 4.2 mEq/L, and all other laboratory values are normal. Which of the following is the most appropriate to add to his regimen?

A. Terazosin 2 mg daily
B. Spironolactone 25 mg daily
C. Clonidine 0.1 mg twice daily
D. Chlorthalidone 12.5 mg daily

Death will be optional by the year 2045DYING will be 'optional' within just 22 years and the ageing process will be 'rev...
07/05/2023

Death will be optional by the year 2045

DYING will be 'optional' within just 22 years and the ageing process will be 'reversible', according to two genetic engineers during the presentation of their new book in Barcelona.

My good friend and member of Transhuman Coin Scientific Advisory Board, José Luis Cordeiro, born in Venezuela to Spanish parents, and Cambridge (UK) mathematician David Wood, founder of the operating system 'Symbian', published The Death of Death and say immortality is a real and scientific possibility that could come much earlier than originally thought.

Humans will only die in accidents, never of natural causes or illness, by around the year 2045, say Cordeiro and Wood, who say it is 'crucial' that old age starts to be classified as an 'illness' so that publicly-funded research into its 'cure' can extend.

Nanotechnology is key, among other new genetic manipulation techniques, the engineers said during the presentation at Barcelona's Equestrian Circle.

The process will involve turning 'bad' genes into healthy ones, eliminating dead cells from the body, repairing damaged cells, treatments with stem cells and 'printing' vital organs in 3D.

Cordeiro, who studied at the Massachusetts Institute of Technology (MIT) in the USA, says he has 'chosen not to die' and that in 30 years' time, he will be 'younger than he is today'.

Ageing is the result of DNA 'tails', known as 'telomeres', in chromosomes – of which every cell except red blood and s*x cells has 23 pairs – becoming shorter, and reversing ageing involves lengthening the telomeres.

Telomeres become damaged and shortened with the passage of time, a process that speeds up in the event of toxins entering the body – smoking, alcohol and air pollution are among elements that reduce the length of telomeres, thus accelerating ageing.

Cordeiro and Wood believe that within 10 years, illnesses such as cancer will be curable, and that major international corporations such as Google will be 'entering the field of medicine' because they are 'beginning to realise that curing ageing is possible'.

Microsoft has reportedly already announced the setting up of a cryopreservation centre and a scientist is researching the possibility of cancer being completely curable within a decade.

The engineers explain that, although 'people generally do not know about it', it was discovered in 1951 how cancer cells are immortal: when Henrietta Lacks died from cervical cancer, surgeons removed the tumour and kept it – and it is still 'alive' today.

Immortality will not necessarily mean the planet becomes overcrowded, the scientists say: there is still plenty of room for more people on Earth, and these days, people do not have anywhere near as many children as they did in past decades and centuries; plus, 'it will be possible to live in space by then'.

“Japan and the Koreas, if they continue with their current trend of hardly having any children, will become extinct – within two centuries, there'll be no Japanese or Korean people on the planet,” Cordeiro says.

“But thanks to these new techniques, there will indeed be Japanese and Korean people, because they'll live forever and remain young.”

The cost of anti-ageing treatment was compared to that of the latest SmartPhones.

“At first, it'll be expensive, but with a competitive market the price will gradually fall because it'll be something that benefits everyone,” Cordeiro says.

“Technology, when it's new, is poor and extremely expensive, but it eventually becomes democratic and mainstream and becomes cheaper.”

The engineers say they have already been employing their techniques for two years – illegally, but in Colombia where there are fewer regulations covering genetic manipulation.

Elizabeth Parish, their first human patient, 'started to see symptoms of ageing and asked what could be done to prevent it'.

Her treatment is 'very risky and even illegal', Wood explains, but at the moment is going well, has not had any adverse side-effects, and the level of telomeres in her blood is '20 years younger than before'.

“I want Spain to have a place in the world of these technologies and show that we're not mad, it's just that people still don't know about them,” Wood concluded.

Their book, Death of Death will has been published in four languages at first – Spanish, English, Portuguese and Korean – and all proceeds from its sales will be ploughed back into the authors' research.

Copied.

Address

Addis
Addis Ababa
2023

Alerts

Be the first to know and let us send you an email when South Sudanese future pharmacists posts news and promotions. Your email address will not be used for any other purpose, and you can unsubscribe at any time.

Contact The Practice

Send a message to South Sudanese future pharmacists:

Videos

Share