Aklilu Melaku, MD

Aklilu Melaku, MD Dermatologist, Dermatopathologist

Your eyes can grow this too though the skin is the most common soil.
05/11/2022

Your eyes can grow this too though the skin is the most common soil.

28/09/2022

🐈 Kitty Cat Keratin 🐈

You have got to be kitten me with the keratin whorls in this oblique section through the skin.

i♡histo

This is a region of the skin as observed through a🔬. Experts can easily identify this tissue as skin because it has a keratinized stratified squamous surface epithelium (the epidermis). The epidermis of your skin is composed of many stacked layers (stratified) of keratinocytes (the flat/squamous cells whose nuclei make those many, many purple dots surrounding the cat).

This layering of keratinocytes forms a protective physical barrier between the the cells and tissues that are 'us' and the outside world.

The environment that we live in is constantly trying to kill us in many different ways (sun damage, bacteria, viruses, cuts/scrapes etc.) so the keratinocytes in our epidermis actually release an additional layer of protection on the very outer surface of the skin.

This extra layer of protection is a collection of bundled protein fibers called keratin!

Collectively all of this keratin forms the outermost layer of the skin called the stratum corneum. In this image, it is the keratin bundles that have formed the cat!

Keratinocytes spend their lives synthesizing keratin. However, they don't just just secrete it once they have made it. Oh no!

In order to perform their important role the keratinocytes sacrifice themselves (they die) in order to release the protective keratin that they made inside them onto the surface of the epithelium!

Dead keratinocytes and old, dry keratin are constantly shed from the surface. As a result, the dead keratinocytes must be constantly replaced by division of basal keratinocytes in the deepest layer of your epidermis (the basal layer/stratum basale). You can see this row of cells forming a vertical line on the left of the image separating the dermis (pale pink collagen fibers on the far left) from the other keratinocytes of the epidermis.

27/05/2021

Necrotizing Escherichia coli skin and soft tissue infection with malakoplakia-like features mimicking pyoderma gangrenosum https://bit.ly/3unpSIg

Segmental Neurofibromatosis!
30/12/2020

Segmental Neurofibromatosis!

Cutaneous mucinous carcinoma
14/12/2020

Cutaneous mucinous carcinoma

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Addis Ababa
10000

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+251943515151

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