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16/08/2025

Acral erythema (hand-foot skin syndrome) can be caused by chemotherapy agents including:

1. Bleomycin
2. Capecitabine
3. Cisplatin
4. Cyclophosphamide
5. Cytarabine
6. Daunorubicin
7. Docetaxel
8. Doxifluridine
9. Doxorubicin (particularly pegylated liposomal doxorubicin)
10. Etoposide
11. Fludarabine
12. Fluorouracil (infusional regimens)
13. Gemcitabine

Treatment: drug interruption or dose modification, depending on the severity of the reaction, in combination with topical corticosteroids

08/05/2024

03/02/2024

Sildenafil/Viagra:

Erectile dysfunction:

Dose: 50 mg once daily as needed 1 hour before sexual activity; may be taken up to 4 hours before sexual activity. Reduce to 25 mg once daily if side effects occur.
Maximum dose: 100 mg once daily if there is incomplete response.

Caution: avoid concurrent use of other nitrates, Alpha1-Blockers, alcohol, and alprostadil

14/01/2024

Reye's syndrome (RS):

A rare adverse effect of Aspirin in children that affects all organs of the body but is most harmful to the brain and the liver—causing an acute increase of pressure within the brain and, often, massive accumulations of fat in the liver and other organs.

22/10/2023

Chloramphenicol: Gray baby syndrome

Gray baby syndrome is an adverse reaction to chloramphenicol that is characterized by abdominal distention, hemodynamic collapse, and ashen-gray skin discoloration in newborns/neonates.

The syndrome is a result of chloramphenicol impairing myocardial contractility by directly interfering with myocardial tissue respiration and oxidative phosphorylation.

20/10/2023

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