Hiwot fana specialized university hospital drug information center

08/04/2025

Drug safety issue

19/03/2025

04/10/2024

Early Celecoxib Use in Spontaneous Intracerebral Hemorrhage is Associated with Reduced Mortality
Original article 👇👇👇

| Neurocritical Care
https://link.springer.com/article/10.1007/s12028-024-01996-2

01/10/2024

Safety Alert: Unauthorized Artemether 80 mg/ml Injection, Batch No: R213H04F4

Stay vigilant and prioritize patient safety!

23/08/2024

Safety Alert: Recall of Ringer Lactate Infusion
Dear Healthcare Community, Ringer Lactate Infusion, manufactured by Pharmacure Pvt. Ltd., is currently under recall due to quality defects.
What You Need to Do:
Check Your Inventory: Review your stock of Ringer Lactate Infusion. If you have any batches from Pharmacure, pay close attention.
Report Any Affected Batches: If you identify any affected batches, promptly report them to Pharmacure. Cooperation is essential for a successful recall.
Prioritize Patient Safety: Our collective efforts matter. By participating in this recall, we safeguard public health and protect our patients.

14/07/2024

Sepsis detection and management algorithm.

This post aims to help health professionals to detect sepsis early, enhancing patient care and saving lives.

06/07/2024

Commonly Used Drugs in Hypertensive Emergency and preferred Agents According to Comorbidities.

05/07/2024

Comparison of Therapies for Type 2 Diabetes Added to Metformin.

Like, follow and share the page to get more drug and health related informations.

03/07/2024

OVERVIEW OF DIGOXIN TOXICITY

👉Acute digitalis toxicity can result from unintentional, suicidal, or homicidal overdose of the digitalis preparation digoxin, or accidental ingestion of plants that contain cardiac glycosides.

👉Chronic toxicity in patients on digoxin therapy may result from deteriorating renal function, dehydration, electrolyte disturbances, or drug interactions.

SIGN AND SYMPTOMS

👉Digitalis toxicity produces CNS, visual, GI, and cardiac manifestations. Nausea, vomiting, and drowsiness are among the most common extracardiac manifestations.

ELECTROLYTE

👉In acute toxicity, hyperkalemia is common
👉Chronic toxicity is often accompanied by hypokalemia and hypomagnesemia

ELECTROCARDIOGRAPHY

👉Digoxin toxicity may cause almost any dysrhythmia
👉Classically, dysrhythmias associated with increased automaticity and decreased AV conduction occur.
👉Sinus bradycardia and AV conduction blocks are the most common ECG changes in the pediatric population, while ventricular ectopy is more common in adults.
👉Nonparoxysmal atrial tachycardia with heart block and bidirectional ventricular tachycardia are particularly characteristic of severe digitalis toxicity.

MANAGEMENT

👉The best way to guide therapy is to follow the digoxin level and correlate it with serum potassium concentrations and the patient's clinical and ECG findings.
General supportive care and overall management considerations of digitalis toxicity includes the following:
👉Hydration with IV fluids
👉Oxygenation and support of ventilatory function
👉Discontinuation of the drug, and, sometimes, the correction of electrolyte imbalances
👉GI decontamination.
👉Treatment of electrolyte imbalance
👉Digoxin immune Fab
👉Management of dysrhythmias

Reference on comment site

02/07/2024

Antibiotics flash cards

29/06/2024

Understanding antimicrobial pharmacokinetics in critically ill patients to optimize antimicrobial therapy.

28/06/2024

Overview of pharmacology of diuretics