International CML Foundation

International CML Foundation Improving outcomes for patients with CML globally. The International CML Foundation (iCMLf) is on a mission to improve outcomes for patients with CML, globally.

Founded by a dedicated group of hematologists, we are committed to ensuring every patient with CML, no matter where they are in the world, receives the best possible care. We foster international collaboration to elevate knowledge, enhance diagnostics, and drive ground-breaking research. As a charitable foundation with a global reach, we strive to empower physicians, researchers, patients and caregivers alike, in the collective pursuit of a cure. Join us and contribute to a world where a cure for CML is not just a hope, but a reality.

🩺 Dr Delphine Rea — Goldman Prize 2025Join us in celebrating Dr Delphine Rea, recipient of the 2025 iCMLf Goldman Prize....
26/11/2025

🩺 Dr Delphine Rea — Goldman Prize 2025

Join us in celebrating Dr Delphine Rea, recipient of the 2025 iCMLf Goldman Prize.

Dr Rea is honoured for her outstanding leadership in clinical research and her commitment to improving long-term outcomes for people living with CML. Her work has shaped modern approaches to treatment-free remission and deep molecular response — translating research into better patient care around the world.

🎥 Watch her keynote presentation here:
👉 https://buff.ly/e74cugx

Recording now available: Africa Regional Discussion GroupThank you to everyone who joined the Africa Regional Discussion...
25/11/2025

Recording now available: Africa Regional Discussion Group

Thank you to everyone who joined the Africa Regional Discussion Group on November 12th.
If you missed the session - or want to revisit the key points - the recording is now available.

This discussion explored CML and pregnancy in resource-constrained settings, along with practical strategies to improve adherence to therapy.

Recordings are available in English and French.

Watch now: https://buff.ly/xU68g9j

🧬 Professor Satu M. Mustjoki — Rowley Prize 2025Join us in celebrating Professor Satu M. Mustjoki, recipient of the 2025...
19/11/2025

🧬 Professor Satu M. Mustjoki — Rowley Prize 2025

Join us in celebrating Professor Satu M. Mustjoki, recipient of the 2025 iCMLf Rowley Prize.

Professor Mustjoki is recognised for her pioneering contributions to understanding the immune biology of CML and how immune mechanisms influence treatment response and resistance. Her work continues to bridge laboratory discoveries with clinical practice, advancing precision care for patients worldwide.

🎥 Watch her keynote presentation from the ESH-iCMLf Annual John Goldman Conference:
👉 https://buff.ly/oqBtUiK

Join the iCMLf at ASH 2025Alongside the full program of CML sessions at the 67th ASH Annual Meeting, we’re pleased to sh...
18/11/2025

Join the iCMLf at ASH 2025

Alongside the full program of CML sessions at the 67th ASH Annual Meeting, we’re pleased to share two key iCMLf highlights in Orlando this year:

iCMLf Forum – CML from Clinical Controversies to Future Challenges
🗓️ Friday, December 5 | 12:30–3:00 pm
📍 Rosen Plaza Hotel, Orlando
Featuring discussions on the ELN 2025 recommendations, the clinical impact of ASXL1 mutations, and updates from the iCMLf Cure Consortium.
To reserve your place: arlene@cml-foundation.org

iCMLf/HARMONY Foundation Oral Abstract Presentation
Somatic mutations at diagnosis in chronic phase CML receiving frontline imatinib and risk of treatment failure
🗓️ Saturday, December 6 | 10:00 am
Presenter: Professor Susan Branford

This first analysis from the iCMLf/HARMONY CML Genomics project provides important insights into the prognostic role of somatic mutations in CML.

If you’re not attending ASH in person, join us in January for an iCMLf Conversation on the key CML highlights. More details to follow.

Heading into ASH 2025? Here are the key CML sessions to add to your schedule.With more than 8,200 abstracts accepted thi...
17/11/2025

Heading into ASH 2025? Here are the key CML sessions to add to your schedule.

With more than 8,200 abstracts accepted this year, the 67th ASH Annual Meeting promises an exceptional range of CML updates. To help you plan, we’ve highlighted the core CML-focused sessions:

Education Spotlight Session – The changing face of CML
🗓️ Sunday, December 7 | 4:30–5:45 pm (EST)

Oral Abstract Session – Molecular drivers of response and resistance
🗓️ Saturday, December 6 | 9:30–11:00 am (EST)

Oral Abstract Session – Therapeutic agents to enhance patient outcomes
🗓️ Monday, December 8 | 2:45–4:15 pm (EST)

Satellite Symposium – A Master Class in CP-CML
New agents, treatment goals, and clinical challenges
🗓️ Friday, December 5 | 11:00 am–2:00 pm (EST)
(supported by an educational grant from Novartis)

There will also be a large number of CML poster presentations throughout the meeting.

Download the complete CML session overview - https://buff.ly/SVtZ4Mh

More ASH updates coming soon.

Now Available: iCMLf Prize Lecture Recordings from the ESH-iCMLf 27th Annual John Goldman Conference on CML: Biology and...
14/11/2025

Now Available: iCMLf Prize Lecture Recordings from the ESH-iCMLf 27th Annual John Goldman Conference on CML: Biology and Therapy

We’re delighted to share the 2025 iCMLf Prize keynote recordings - honouring three outstanding leaders in the CML community whose work continues to shape research, treatment, and access to care worldwide.

🏅 Rowley Prize: Professor Satu M. Mustjoki (University of Helsinki)
🏅 Goldman Prize: Dr Delphine Rea (Hôpital Saint-Louis, Paris)
🏅 iCMLf Prize: Professor Nicholas Anthony Othieno-Abinya (University of Nairobi, Kenya)

Each lecture offers inspiring insights into the science, progress, and human stories driving advances in CML.

🎥 Watch all keynote presentations here: https://buff.ly/KbhsmMT 

⸻

Happening Today! It's not too late to join us.Join the next iCMLf Regional Discussion Group Meeting for Africa - an inte...
12/11/2025

Happening Today! It's not too late to join us.

Join the next iCMLf Regional Discussion Group Meeting for Africa - an interactive session bringing together CML experts and physicians from across the region.

🩺 Topics:
• CML and pregnancy in resource-constrained settings
• Overcoming challenges in adherence to therapy

🕔 Today – November 12th

Online | Open to all physicians treating CML in Africa
French interpretation available

Join here: https://buff.ly/uROAtbK

11/11/2025

🎥 Highlights from the ESH-iCMLf 27th Annual John Goldman Conference on CML: Biology and Therapy

Thank you to everyone who joined us in Estoril for this year’s conference - three days of connection, collaboration, and cutting-edge science in CML.

From world-leading research presentations to inspiring prize lectures and early morning Fun Run moments, the meeting celebrated innovation and community across the global CML field.

See you next year!

iCMLf Papers of the Month – September & OctoberOur regular Paper of the Month feature took a short pause during the busy...
10/11/2025

iCMLf Papers of the Month – September & October

Our regular Paper of the Month feature took a short pause during the busy period of the ESH–iCMLf 27th Annual John Goldman Conference on CML: Biology and Therapy, but we’re now back with a collection of papers selected by Professor Tim Hughes.

Highlights include:

1️⃣ Impact of ASXL1 at diagnosis in patients with chronic myeloid leukemia receiving frontline potent tyrosine kinase inhibitors: high risk of kinase domain mutations
Shanmunagathan N et al. Blood, September 2025 (epub ahead of print)
https://buff.ly/SHn2fxz

2️⃣ A newcomer in allosteric therapy for Ph+ leukemias
Delphine Rea. Blood, October 2025 – open access publication
https://buff.ly/zPHmXpV

3️⃣ Uncommon phenotypes of BCR::ABL1-positive chronic myelogenous leukemia
Jajosky AN et al. Haematologica, September 2025 – open access publication
https://buff.ly/VNMzl11

4️⃣ Revisiting treatment-free remission: A case of late molecular recurrence in chronic myeloid leukemia
Sharma V et al. J Assoc Physicians India, September 2025
– open access publication
https://buff.ly/NNWFPpi

📖 Explore the full list of papers on our website:
https://buff.ly/9DoiXTp

CML Physicians in Africa – One Week to Go!The final 2025 iCMLf Regional Discussion Group Meeting for Africa takes place ...
05/11/2025

CML Physicians in Africa – One Week to Go!

The final 2025 iCMLf Regional Discussion Group Meeting for Africa takes place next Wednesday, November 12th. Join CML experts and colleagues from across Africa to explore key challenges in treatment and patient care.

Topics:
• CML and pregnancy in resource-constrained settings
• Overcoming challenges in adherence to therapy

🗓 Date: November 12th
Online | Open to all physicians treating CML in Africa
French interpretation available

⏰ Start times:
Accra/Dakar – 17:00 | Rabat/Abuja – 18:00 | Khartoum/Beira – 19:00 | Addis Ababa/Moshi/Nairobi – 20:00

🔗 Register now: https://us02web.zoom.us/meeting/register/M5btYKFERF28Id7J9_MKWg #/registration

05/11/2025

📣 STARTS THIS FRIDAY!
DON’T MISS THE OPPORTUNITY, REGISTER NOW ➡ bit.ly/3ZQWwEa
ESH- 27th Annual John Goldman Conference on Chronic Myeloid Leukemia: Biology and Therapy
🎓Chairs: Jorge Eduardo Cortes, MD Timothy Hughes, Daniela Krause


International CML Foundation Sociedade Portuguesa de Hematologia British Society for Haematology

iCMLf Abstract Selected for Oral Presentation at ASH 2025We’re delighted to share that the first analysis from the iCMLf...
04/11/2025

iCMLf Abstract Selected for Oral Presentation at ASH 2025

We’re delighted to share that the first analysis from the iCMLf/HARMONY Foundation CML Genomics Project will be presented at the ASH Annual Meeting 2025.

Professor Susan Branford will present:
Somatic mutations at diagnosis in patients with chronic phase CML receiving frontline imatinib are associated with a higher rate of treatment failure: First analysis from the International CML Foundation (iCMLf) Genomics Alliance on the HARMONY platform.

🗓 Saturday, December 6th, 9:30am (Orlando time)
📍 Oral Abstract Session: Chronic Myeloid Leukemia – Clinical and Epidemiological

Based on data from 468 patients, the study shows that somatic mutations—particularly ASXL1—may influence treatment outcomes, offering new insights for future risk stratification and CML management.

Congratulations to Professor Branford and all collaborators involved in this milestone work from the iCMLf/HARMONY CML Genomics Project.

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