PDPU - IBGRL

PDPU - IBGRL Contact information, map and directions, contact form, opening hours, services, ratings, photos, videos and announcements from PDPU - IBGRL, Medical Lab, NHS BLOOD AND TRANSPLANT, Bristol.

The Protein Development and Production Unit (PDPU), focuses on the production and development of new and existing cell lines to supply monoclonal antibodies and recombinant proteins for research, diagnostic and therapeutic use.

PDPU can undertake the following services on either a collaborative or commercial basis (this list is not exhaustive):- ...
21/03/2024

PDPU can undertake the following services on either a collaborative or commercial basis (this list is not exhaustive):

- Production of antibodies and protein antigens from mouse, rat, human and insect cell lines
- Antibody engineering including isotype switching
- Antibody labelling e.g. FITC, RPE, AP
- Antibody fragmentation and fragment purification and labelling
Protein purification, scale up and QC validation to customer specification including low endotoxin conditions
- CE marking of derived reagents
- Development of customer cell lines, including optimisation and stability studies and mycoplasma testing
- New hybridoma and recombinant cell line generation, optimisation and stability studies
- Phage display library screening (using antigen provided by customer)
- Provision of IBGRL cell lines under a license agreement
- Diagnostic assay development, validation & qualification (including CE marking)
- Diagnostic platform development, validation & qualification
- Provision of IBGRL cell lines under a license agreement

If you would like to request a service that is not listed please contact us: Enquiries.IBGRL@nhsbt.nhs.uk

Please note: IBGRL does not currently undertake GMP manufacturing services but may support development of a GMP process. Where responses indicate a request for GMP manufacturing, IBGRL will pass details onto the Cellular & Molecular Therapies and/or Tissue & Eye Services functions of NHSBT.

Since April 1991, the Protein Development and Production Unit (PDPU) have produced a range of monoclonal antibodies and ...
21/03/2024

Since April 1991, the Protein Development and Production Unit (PDPU) have produced a range of monoclonal antibodies and soluble recombinant proteins for immunohaematological research marketed under the name IBGRL Research Products (IRP).

The antibodies cover a range of specificities of interest to researchers in the fields of immunology, haematology, cell biology and biochemistry.

Most of the monoclonal antibodies are produced for research use but some antibodies and recombinant proteins bear the CE mark or are in the pipeline to be CE marked and are used for diagnostic purposes.

PDPU produce CE marked fluorescently labelled antibodies for diagnosis of Feto-Maternal Haemorrhage (FMH). These CE marked products are produced on behalf of NHSBT Reagents (14 Estuary Banks, L24 8RB), who are the legal manufacturer.

In the pipeline to gain the CE mark, we produce soluble recombinant protein reagent called KNIR; this reagent allows the detection and identification of clinically significant blood group specific antibodies in patient samples by inhibition of 'nuisance' antibodies.

In addition, we have produced srCD38 which inhibits red cell agglutination by therapeutic anti-CD38 monoclonal antibodies (e.g. Daratumumab) in both gel and tube agglutination tests.

IRP monoclonal antibodies are available as culture supernatant, purified antibody and FITC, PE, Biotin, APC, i-Fluor and HRP conjugated antibodies.

PDPU can also:

Custom produce antibodies to your particular specification
Provide other conjugates
Prepare Fab and F(ab)2 fragments

Address

NHS BLOOD AND TRANSPLANT
Bristol
BS347QH

Opening Hours

Monday 9am - 5:30pm
Tuesday 9am - 5:30pm
Wednesday 9am - 5:30pm
Thursday 9am - 5:30pm
Friday 9am - 5:30pm

Telephone

+441179217500

Alerts

Be the first to know and let us send you an email when PDPU - IBGRL posts news and promotions. Your email address will not be used for any other purpose, and you can unsubscribe at any time.

Featured

Share

Share on Facebook Share on Twitter Share on LinkedIn
Share on Pinterest Share on Reddit Share via Email
Share on WhatsApp Share on Instagram Share on Telegram

Category