MRC Epidemiology Unit

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MRC Epidemiology Unit Obesity, type 2 diabetes and related metabolic disorders present a major and growing global public health challenge.

The MRC Epidemiology Unit investigates the individual and combined effects of genetic, developmental, behavioural & environmental factors that cause obesity, type 2 diabetes and to develop and evaluate strategies to prevent them and their consequences. These disorders result from a complex interplay between genetic, developmental, behavioural and environmental factors that operate throughout life. The mission of the MRC Epidemiology Unit is to investigate the individual and combined effects of these factors and to develop and evaluate strategies to prevent these diseases and their consequences. In this way, we are working to improve the health of people in the UK and around the world. We are a Medical Research Council Unit embedded as a department of the University of Cambridge School of Clinical Medicine. The Unit is part of the Wellcome – MRC Institute of Metabolic Science (IMS) on the Cambridge Biomedical Campus, where the principle offices and laboratories of the Unit are physically located. Unit Director Professor Nick Wareham is Co-Director of the IMS with Professor Sir Stephen O’Rahilly. Being embedded in the IMS is critical to our aspiration to follow up associations between exposures and metabolic disease outcomes to determine possible causality and mechanisms. The Unit is also a part of Cambridge Population Health Sciences, a three department partnership of the Department of Public Health and Primary Care and the MRC Biostatistics Unit. Collectively, the Partnership pursues a wide range of research across epidemiology, biostatistics, population health and primary care, and delivers the Masters courses in Population Health Sciences. We are delivering on our mission through eight High Level Objectives which connect all our research programmes and infrastructure.

- To investigate the causes of obesity, diabetes and related metabolic disorders
- To develop understanding of mechanisms identified by population-based studies
- To develop and evaluate individual level approaches to the prevention of diabetes, obesity and related metabolic disorders in children and adults
- To inform, develop and evaluate population-based approaches to improving health
- To develop new methods, resources and tools for epidemiological and public health research
- To investigate approaches to improving global health, particularly in low and middle income countries
- To build capacity for conducting, understanding and using local, national, and international epidemiology and public health research
- To contribute to the translation of research evidence into policy and practice

The main objectives of each individual research programme are mapped to one or more of these High Level Objectives, which therefore provide a unifying framework to illustrate and augment the cross-links and collaborations between programmes.

As the Health Secretary announces that the Soft-Drinks Industry Levy (SDIL) will be extended to cover milkshakes and pre...
25/11/2025

As the Health Secretary announces that the Soft-Drinks Industry Levy (SDIL) will be extended to cover milkshakes and pre-packaged lattes, it's worth taking a look back at a few findings from the evaluation of the SDIL undertaken by Professor Martin White and colleagues.

An analysis of UK National Diet and Nutrition Survey data led by Dr Nina Rogers and Professor Jean Adams found daily free sugar intake fell by 5g in children and 11g in adults following the announcement of the SDIL in 2016.

https://buff.ly/xLDWsTw

Research by Dr Nina Rogers and Professor David Conway indicates the SDIL may have reduced tooth removal in under 18's due to tooth decay by 12%, saving >5,500 hospital admissions for tooth decay with the largest reductions in children aged 0-9 years.

https://buff.ly/v7cwv90

Despite widespread industry fears the SDIL would harm their businesses, research led by Dr Cherry Law found that leading UK soft drinks companies continued to experience positive growth in their share prices during its implementation.

https://buff.ly/i57wGtr

Looking for reliable, high-quality biological sample processing and storage services? The BioRepository at the MRC Epide...
25/11/2025

Looking for reliable, high-quality biological sample processing and storage services?

The BioRepository at the MRC Epidemiology Unit has supported research studies and trials since 2017, with a dedicated team and state-of-the-art facilities at the Cambridge Biomedical Campus and Research Park.

We offer:
✅ Blood fractionation, DNA extraction & QC
✅ Secure ULT storage (-80°C, -20°C, LN tanks)
✅ HTA-licensed operations and full sample traceability via LabVantage LIMS
✅ Fast sample retrieval and dispatch
📍 Based in Cambridge, we’re here to support academic and industry partners alike.

At the BioRepository, we're proud to combine scientific precision with environmental responsibility. Our newly expanded Nordic ULT Freezer System offers:

🔒 100% backup for sample security
🌡️ 24/7 monitoring & telemetry
🌍 Significant energy savings and reduced carbon footprint

📨 Get in touch for a tailored quote: BioRepManager@mrc-epid.cam.ac.uk

Website: https://buff.ly/59J0cNp

Can we trust the science of nutrition?That was the question asked of the Unit’s Professor Nita Forouhi and others on an ...
24/11/2025

Can we trust the science of nutrition?

That was the question asked of the Unit’s Professor Nita Forouhi and others on an expert panel for the BBC’s A Question of Science.

Prof. Brian Cox and guests dive into the complex world of diet, nutrition & food choices.

Listen - https://buff.ly/DSDX2UY

Analysis of changes in physical activity and diet quality in 7,256 Fenland Study participants has found that while impro...
21/11/2025

Analysis of changes in physical activity and diet quality in 7,256 Fenland Study participants has found that while improved diet quality and increased physical activity were each independently associated with lower increases in body fat, the greatest benefits were achieved by combining both.

The analysis of data from Fenland participants, who had a mean age of 49 years at baseline and 56 years at follow-up, was led by MRC Epidemiology Unit researchers Dr Shayan Aryannezhad and Professor Nita Forouhi.

At both baseline and at follow-up seven years later, Fenland participants’ diet quality was assessed by the degree of adherence to the Mediterranean diet pattern using a food frequency questionnaire, and the quantity and distribution of body fat was measured objectively using DEXA.

Using DEXA enabled the researchers to demonstrate that visceral fat stored around the organs in the abdomen, which is linked to a higher risk of metabolic diseases, was particularly responsive to the changes in health behaviours.

The results highlight the health benefit from making small, sustained changes to behaviours, and Professor Forouhi urges policymakers to seek to alter the food and physical activity environments to make healthier choices more accessible for all.

"Nutrition must no longer remain a missing pillar in obesity management medication care."Dr Marie Spreckley, Dr Cara Rug...
17/11/2025

"Nutrition must no longer remain a missing pillar in obesity management medication care."

Dr Marie Spreckley, Dr Cara Ruggiero and Dr Adrian Brown discuss lessons from bariatric interventions on the nutritional support needed for individuakls undergoing GLP-1 receptor agonist assisted weight loss therapy.

Read the International Journal of Obesity paper at https://buff.ly/wpBiBEt

Dr Spreckley is now leading the new AMPLIFY study that seeks to understand how people experience GLP-1 receptor agonist-based therapies, such as semaglutide and tirzepatide. This will inform guidance and wrap-around care models for people using these weight management medications.

Read our recent news post on the AMPLIFY Study at https://buff.ly/o6auZ0q

Today is World Diabetes Day, and we end our Brief Interval podcast series with Dr Charlotte Boughton discussing the use ...
14/11/2025

Today is World Diabetes Day, and we end our Brief Interval podcast series with Dr Charlotte Boughton discussing the use of automated insulin delivery systems with the aim of improving outcomes for people with type 2 diabetes.

Charlotte is a Clinical Researcher at Institute of Metabolic Science - Metabolic Research Laboratories, University of Cambridge.

Listen – https://buff.ly/zJrvFRo

New analysis by Katherine Kentistou and colleagues of rare coding variants in 234,675 UK Biobank participants identifies...
14/11/2025

New analysis by Katherine Kentistou and colleagues of rare coding variants in 234,675 UK Biobank participants identifies 9 genes that regulate fetal adipose tissue and fetoplacental angiogenesis as determinants of birth weight, and highlights the role of insulin-like growth factors in fetal growth.

Read the Nature communications paper at https://buff.ly/tLbRjj4

It’s believed that by 2025 1.27 billion people will be diagnosed with type 2 diabetes. And it’s crucial to understand ho...
13/11/2025

It’s believed that by 2025 1.27 billion people will be diagnosed with type 2 diabetes. And it’s crucial to understand how our diet can impact the onset of the condition.

Dr Chunxiao Li is a Research Associate at the Unit and in this podcast she discusses the association of meat consumption on type 2 diabetes.

Listen - https://buff.ly/o2yDBfB
Read more - https://buff.ly/XpFXgAx

AMPLIFY is a new study led by Dr Marie Spreckley that seeks to understand how people experience next-generation incretin...
12/11/2025

AMPLIFY is a new study led by Dr Marie Spreckley that seeks to understand how people experience next-generation incretin-based therapies, such as semaglutide and tirzepatide, when used for weight management.

By exploring the lived experiences of adults from diverse communities across the UK, AMPLIFY will inform how best to support individuals using, or having recently stopped using, these treatments.

AMPLIFY is supported by the University of Cambridge Public Engagement Starter Fund, and will be co-designed with partners from Obesity Voices, a national network of patients and members of public with lived experience of obesity.

Read our news post at https://buff.ly/o6auZ0q

There are a multitude of reasons a pregnant woman can develop gestational diabetes; being overweight or obese can be fac...
12/11/2025

There are a multitude of reasons a pregnant woman can develop gestational diabetes; being overweight or obese can be factors but some may be genetically predisposed to developing the condition.

In this podcast, researchers from the IMS Metabolic Research Laboratories are investigating the interventions a pregnant woman can use to mitigate the onset of the condition.

Guests:
Dr Denise Fernandez-Twinn
Dr Adriana Paz Cordova Casanova
Dr Lais Vales Mennitti

Listen - https://buff.ly/7Kymdzy

1.27 billion people are expected to be diagnosed with type 2 diabetes by 2050.This week we’ll be hearing from researcher...
11/11/2025

1.27 billion people are expected to be diagnosed with type 2 diabetes by 2050.

This week we’ll be hearing from researchers from the MRC Epidemiology Unit and the IMS Metabolic Research Laboratory, at the University of Cambridge.

We’ll find out more about their research and how they hope to change how diabetes is impacting our lives.

Dr Ana Luiza Arruda is a Research Associate at the MRC Epidemiology Unit, and in this podcast Ana discusses the multiple morbidities of diabetes.

Listen - https://buff.ly/ZGB46Go

On 10 November researchers from the MRC Epidemiology Unit took part in the University of Cambridge Postdocs of Cambridge...
11/11/2025

On 10 November researchers from the MRC Epidemiology Unit took part in the University of Cambridge Postdocs of Cambridge (PdOC) Research Showcase 2025.

Dr Ghufran Al Sayed presented the poster 'Co-designing digital health behaviour change interventions with adolescents: a systematic review'.

Dr Marie Spreckley presented the poster 'Supporting Weight Management (SWiM): evaluating the effectiveness, equity and cost-effectiveness of using acceptance based guided self -help to improve long term outcomes of weight management interventions'.

Dr Cara Ruggiero gave a flash talk entitled 'The cost-of-living crisis and infant feeding during the first 1000 days: Qualitative insights from parents and healthcare professionals' for which was awarded the runner-up prize.

Marie, with Dr Álvaro López-Acosta of the Departments of Biochemistry and Chemistry. organised the event as part of their role as the Research Development Officers of the PdOC Committee, and co-chaired a panel discussion on AI featuring external speakers from industry.

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MRC Epidemiology Unit, University Of Cambridge School Of Clinical Medicine, Box 285 Institute Of Metabolic Science, Cambridge Biomedical Campus

CB20QQ

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