APEX - Altitude Physiology Expeditions

APEX - Altitude Physiology Expeditions APEX is a charity founded in 2000. Our next expedition APEX 7 will be to Bolivia in 2025!

Apex (Altitude Physiology Expeditions) is a charity founded in 2000 with the aim of performing high altitude medical research, and educating the public about the topic. We conduct research expeditions to high altitude, and give presentations and open lectures about our work. So far, five separate Apex expeditions have travelled to Bolivia to conduct exciting, cutting edge medical research. The research aims to improve the safety and wellbeing of millions of climbers and skiers who ascend to high altitude each year. It could also help patients in hospital intensive care units who suffer from very low blood oxygen levels. We aim to specifically assist young researchers in conducting these expeditions. The latest expedition, APEX 6, was organised by 4 senior medical students at the University of Edinburgh. In June 2022, they travelled to Huayna Potosi Mountain, Bolivia, to conduct research into altitude physiology. If you are interested in travel, expeditions or physiology at high altitude please like this page to be kept up to date with all our latest expedition updates, activities and research.

INTERNATIONAL RESEARCH PRESENTATIONAPEX 6 Expedition Leader Dr Oliver Vick had the pleasure of sharing preliminary findi...
08/09/2025

INTERNATIONAL RESEARCH PRESENTATION

APEX 6 Expedition Leader Dr Oliver Vick had the pleasure of sharing preliminary findings of the expeditionโ€™s RESET Trial at the Wilderness Medical Society Summer Conference in Lake Geneva, WI, USA this summer.

The RESET trial investigated a novel multimodal intervention to help accelerate body clock resetting on APEX 6. We hope to share final results soon.

We are incredibly grateful to the WMS and the Academy of Wilderness Medicine for their support of the trial through the Charles S Houston Grant.

Wilderness Medical Society
APEX - Altitude Physiology Expeditions

VIVA EL STRONGEST๐Ÿฏ๐Ÿ”ฅBy Alastair HolliganThe early rise on the second day allowed for the tremendous discovery that La Paz...
03/07/2025

VIVA EL STRONGEST๐Ÿฏ๐Ÿ”ฅ

By Alastair Holligan

The early rise on the second day allowed for the tremendous discovery that La Paz is in fact quite cold at times and the hostel appears to have no hot water. A crisp shower-defibrillation kick started the day and we head downstairs for the brief. Going downstairs - fine, going upstairs - borderline respiratory arrest.

To hear more about Allyโ€™s day and the amazing football we had the pleasure of witnessing, read our blog linked in our bio!

An Unexpected Encounter and Bolivian Pride!๐Ÿ‡ง๐Ÿ‡ด๐Ÿณ๏ธโ€๐ŸŒˆRead about these two adventures on the blog linked in our bio!
03/07/2025

An Unexpected Encounter and Bolivian Pride!๐Ÿ‡ง๐Ÿ‡ด๐Ÿณ๏ธโ€๐ŸŒˆ

Read about these two adventures on the blog linked in our bio!

Journey to La Paz๐Ÿ”ฅ๐Ÿ‡ง๐Ÿ‡ดBy Amelia Aves & Raphael GutierrezThe journey to La Paz was quite an epic one, taking us 46 hours to...
02/07/2025

Journey to La Paz๐Ÿ”ฅ๐Ÿ‡ง๐Ÿ‡ด

By Amelia Aves & Raphael Gutierrez

The journey to La Paz was quite an epic one, taking us 46 hours total! The journey began for all of us at Heathrow where we gathered in terminal 4 and collected our very stylish APEX 7 branded fleeces and coats! We were split into different flight routes, and sent to all four corners of the earth (literally).

Go and read the rest of the sordid tale on our blog, linked in our bio!๐Ÿซก

๐Ÿ”๏ธ APEX 7 HBI ๐Ÿ”๏ธAPEX 7 HBI will investigate markers of neuronal injury at altitude, specifically GFAP and UCH-L1. It is ...
27/06/2025

๐Ÿ”๏ธ APEX 7 HBI ๐Ÿ”๏ธ

APEX 7 HBI will investigate markers of neuronal injury at altitude, specifically GFAP and UCH-L1. It is led by Anya and Ella A, and supervised by Mr Andrew Sutherland.

Mr Andrew Sutherland is a consultant transplant surgeon at the Royal Infirmary of Edinburgh. He has been involved in APEX since 2001, where he was the doctor on the very first APEX expedition. He led a research project on APEX 2 which also looked at markers of neuronal injury, and now sits on the APEX Charity Management Committee. His research interests include ischaemia reperfusion injury, ischaemic preconditioning, high-altitude physiology and new technologies in organ preservation.

๐Ÿ”๏ธ APEX 7 NEU ๐Ÿ”๏ธAPEX 7 NEU builds on previous APEX research studies and will investigate neutrophil responses to prolong...
27/06/2025

๐Ÿ”๏ธ APEX 7 NEU ๐Ÿ”๏ธ

APEX 7 NEU builds on previous APEX research studies and will investigate neutrophil responses to prolonged hypoxia. The neutrophil project has always been a highlight amongst the expedition team, where volunteers have been trained in the processing of samples and have been able to help with this in the high-altitude research laboratory. This has provided valuable experience in practical research skills in a unique environment.

We are excited to be working with the Brown Lab once again!

๐Ÿ”๏ธ APEX 7 CORE ๐Ÿ”๏ธAPEX 7 CORE will investigate the accuracy of pulse oximetry devices in hypoxia by comparing oxygen satu...
26/06/2025

๐Ÿ”๏ธ APEX 7 CORE ๐Ÿ”๏ธ

APEX 7 CORE will investigate the accuracy of pulse oximetry devices in hypoxia by comparing oxygen saturation readings to the gold standard, arterial blood gases. This element is led by Anya, Cameron and David and supervised by Professor Kenneth Baillie.

We are incredibly grateful to for supporting this study through their External Research Programme, through which they will be providing both devices and funding. Thank you for your support!

๐Ÿ”๏ธ APEX 7 SKIN ๐Ÿ”๏ธAPEX 7 SKIN is led by Colette Revadillo and supervised by Prof Sara Brown. It aims to investigate the d...
26/06/2025

๐Ÿ”๏ธ APEX 7 SKIN ๐Ÿ”๏ธ

APEX 7 SKIN is led by Colette Revadillo and supervised by Prof Sara Brown. It aims to investigate the dermatological adaptations which occur at altitude!

ONE WEEK COUNTDOWN !!See you in Heathrow soon ๐Ÿ”๏ธ๐Ÿฆ™๐Ÿ‡ง๐Ÿ‡ด
19/06/2025

ONE WEEK COUNTDOWN !!

See you in Heathrow soon ๐Ÿ”๏ธ๐Ÿฆ™๐Ÿ‡ง๐Ÿ‡ด

๐Ÿ”๏ธ APEX 7 eQTL ๐Ÿ”๏ธAPEX 7 eQTL will investigate expression quantitative trait loci (eQTLs) in hypobaric hypoxia. This rese...
12/06/2025

๐Ÿ”๏ธ APEX 7 eQTL ๐Ÿ”๏ธ

APEX 7 eQTL will investigate expression quantitative trait loci (eQTLs) in hypobaric hypoxia. This research element is led by Anya (head of research) and supervised by Professor Kenneth Baillie (The University of Edinburgh).

Prof Baillie led the very first APEX expedition in 2001, and founded the APEX Charity. He is Chief Investigator of the APEX 7 Study, and has contributed greatly to all APEX expeditions through providing mentorship and support. He works as a consultant in the intensive care unit at the Royal Infirmary of Edinburgh, and is Co-Director of the Pandemic Science Hub. During the Covid outbreak in 2020-2021, he led the UK-wide GenOMICC and ISARIC4C studies, and contributed to the design and delivery of the RECOVERY trial. He discovered new biological mechanisms underlying critical illness in Covid, and contributed to the discovery of effective drug treatments to reduce mortality.

Prof Baillie leads a research programme in translational genomics- using genetic signals from critically ill patients to identify both the targets for drug therapy, and the groups of patients likely to benefit most from any treatment, and testing those therapeutic ideas in highly-efficient model systems.

APEX 7 eQTL will be a continuation of work from previous expeditions: APEX 4 (2014), APEX 5 (2017), and APEX 6(2022).

๐Ÿ”๏ธ APEX 7 HEAT ๐Ÿ”๏ธNext up, APEX 7 HEAT led by Camille (Head of FGS) and Ella M (Head of Volunteers)! This study aims to i...
11/06/2025

๐Ÿ”๏ธ APEX 7 HEAT ๐Ÿ”๏ธ

Next up, APEX 7 HEAT led by Camille (Head of FGS) and Ella M (Head of Volunteers)! This study aims to investigate the metabolic adaptations which occur in hypobaric hypoxia, and is supervised by Dr Zoi Michailidou (Nottingham Trent University).

Whilst working at the University of Edinburgh, Dr Michailidou was aware of the unique opportunities APEX provides medical students to explore human physiology at high altitude that fit very well with her research programme. Zoi put herself forward as a mentor and proposed a project, which evolved to be APEX 7 HEAT.

We are very excited to be collaborating with on this study!

๐Ÿ”๏ธ APEX 7 HiCORT ๐Ÿ”๏ธThe APEX 7 Study contains multiple different research elements, each with their own study lead and su...
10/06/2025

๐Ÿ”๏ธ APEX 7 HiCORT ๐Ÿ”๏ธ

The APEX 7 Study contains multiple different research elements, each with their own study lead and supervisor. First up in our series to introduce these elements is APEX 7 HiCORT, which will investigate the impact of acute hypobaric hypoxia on daily cortisol profiles at the tissue level. This is led by David (expedition co-leader) and supervised by Dr Nina Rzechorzek (The University of Cambridge).

Dr Rzechorzek has contributed greatly to APEX for many years, first as a student in 2002 (APEX 2 Team Leader) and now sits on the APEX Charity Management Committee. She is also chief investigator for the RESET Trial (APEX 6) alongside APEX 7 HiCORT.

APEX 7 HiCORT involves a large multidisciplinary team from , and industry partners including Dynamic Therapeutics, , BodyCap, M Dialysis, Linton Instrumentation, and Elson Space Engineering. A huge thank you to our sponsors, funders and collaborators!

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