ElevaCell

ElevaCell Emanuele’s osteopathic approach sees pain as a complex blend of physical, psychological, and social factors. He is also UK leader in Oxygen-Ozone therapy.

He crafts personalized treatment plans, earning trust from CEOs, royals, and elite athletes.

💡 Did you know that emotions can trigger heart arrhythmias?A review highlights something fascinating: the brain and the ...
22/08/2025

💡 Did you know that emotions can trigger heart arrhythmias?

A review highlights something fascinating: the brain and the heart operate as an interactive unit, where both hemispheres of the brain influence the autonomic nervous system differently.

-Right hemisphere → more linked to negative emotion + sympathetic activation (stress, fear, anger).
-Left hemisphere → more linked to positive emotion + parasympathetic activity (calm, recovery).

This asymmetry means that emotional states don’t just “stress the heart” — they alter the spatial and temporal patterns of nerve input to the myocardium, shaping electrical stability or instability.

What’s striking is how specific emotions, especially anger, create pro-arrhythmic conditions by destabilising cardiac repolarisation. History and research both show cases where sudden emotional surges led directly to fatal cardiac events.

👉 This makes one thing clear: if we want to truly assess cardiac risk, HRV, or autonomic balance, we need to understand brain–heart laterality. Looking at just one hemisphere, or one-sided measures, misses half the story. And guess what? All the wearables in the market do that.

But stay tuned, I may have the solution for this 😃

Emotions aren’t just “in the mind.” They have fingerprints in our heart’s rhythm.

Taggart, P., Boyett, M. R., Logantha, S. J. R., Lambiase, P. D. (2011). Anger, emotion, and arrhythmias: from brain to heart. Frontiers in physiology, 2, 67.

8 out of 10 people that are told they have “sciatica”… don’t.I see it all the time in clinic.Someone comes in saying, “M...
15/08/2025

8 out of 10 people that are told they have “sciatica”… don’t.

I see it all the time in clinic.
Someone comes in saying, “My doctor said I have sciatica,” expecting that a disc is pressing on a nerve root. But here’s the truth:

Sciatica is not a diagnosis—it’s just a symptom.
It simply means pain running down the back of the leg. Yet most people picture a bulging disc crushing a nerve. The problem with this is a catastrophic vicious cycle of protective behaviours that significantly increase the chance for that person to develop chronic lower back pain.

In reality? Less than 20% of cases I see match that discopathy picture.
The other 80+% are something else entirely: myofascial or neural dysfunction—tight or irritated tissues, fascial tension, or sensitised peripheral nerves—sending pain down the leg without any nerve root compression.

And pain is rarely just mechanical.
Fear, anxiety, and past pain experiences can make the nervous system hypersensitive, turning up the volume on signals.

On a cellular level, shifts in extracellular water (ECW), extracellular matrix (ECM) quality, and extracellular conductivity (ECK) can disrupt nerve conduction—fueling pain even more. None of this shows up on a standard MRI and guess what, they are all compromised in these cohort of people and they all can make pain worse.

If we want to treat “sciatica” effectively, we have to stop chasing the disc in every case and start looking at the full picture—mechanical, neurological, biological, and psychological.

That’s the future of holistic care I’m building, backed by science, and to disrupt the old, weak, unhelpful and at times harmful model of care we are used to recieve.

Stay tuned 😃

We talk a lot about stress, performance, burnout, brain fog—but how often do we actually measure how well your brain is ...
12/08/2025

We talk a lot about stress, performance, burnout, brain fog—but how often do we actually measure how well your brain is functioning under pressure?

Thanks to some non-invasive technology this is possible.

In just minutes, we can now assess real-time oxygenation and blood flow in the prefrontal cortex—the brain’s control center for focus, decision-making, emotional regulation, resilience, and long-term performance.

This isn’t just another mental health tool. It’s a clinical-grade system that helps detect dysfunction early—before it becomes chronic—and uses targeted neurofeedback to restore the brain’s regulatory capacity.

It’s being used across a wide range of applications:

Chronic stress and burnout
Pain Management
Mood and cognitive decline
Addictions and compulsive behavior
Post-concussion and micro-trauma syndromes (MMA, rugby, etc.)
Age-related neurodegeneration
Fatigue, brain fog, anxiety
Recovery and performance in elite athletes

Here’s the exciting part:
I’m working to make this a core component of the in-depth diagnostics I am building.

This isn’t surface-level wellness—it’s real, measurable neurophysiology backed by science.
And it’s going to be available to more than just elite performers.

We’re creating something different.
Something that will finally connect brain function, body function, and performance—and show you how to train them, not just talk about them.

More to come very soon. Stay close.

This week I received a newsletter from a well-known longevity clinic in London. The topic? What high performers do in th...
08/08/2025

This week I received a newsletter from a well-known longevity clinic in London. The topic? What high performers do in the morning to boost energy and support longevity.

The list included:

Hydration
Sunlight
Movement
NAD+

All good things. But let’s be honest—this is the kind of surface-level advice you can find in any health guru’s Instagram reel or ChatGPT summary. It’s useful, yes. But it barely scratches the surface of what true high performers actually do to stay sharp, recover faster, and extend their healthy years.

Working closely with a niche group of elite performers—athletes, executives, creatives—I’ve seen first-hand that their protocols go far beyond water and vitamins.

The truth? The core of their longevity and energy strategy is anything but simplistic. It’s built on detailed physiological understanding, constant adaptation, and clinical-grade interventions most people will never hear about on the internet.

Here’s how it gets more complex:

-Real-time autonomic nervous system assessment (the Stress system) that gives performers daily exercises to stay in healthy balanced range, ready for their task.

-Epigenetic analysis that tells them about enviornmental factors and predisposing factors, strengths and weakness of their unique system.

-Qualitative body composition and extracellular matrix analysis to tell them about systemic inflammation

-Two-dimensional bioelectrical analysis to detect and localize chronic inflammation and assess the body’s stress response capacity, for precision recovery.

-Prefrontal cortex functional analysis, assessing cognitive and emotional functions, key elements of performance.

The list is long.

This is the kind of model I’m developing—one that merges advanced diagnostics with therapeutics tailored for performance, recovery, and long-term health.

The goal? To make this level of care—once reserved for the few—accessible to more people who want to feel better, live longer, and perform at their best.

Because true longevity doesn’t start with a supplement.
It starts with understanding how your body really works. It doesn’t target symptoms reliefs, but how our own physiology can be optimised.

“Fit on the outside, inflamed on the inside?”I just reviewed a study that seriously challenges how we define health and ...
05/08/2025

“Fit on the outside, inflamed on the inside?”

I just reviewed a study that seriously challenges how we define health and diagnose stress-related conditions. (Tsigos, C., 2015)

It looked at 100,000+ people and compared lean individuals with and without what today are recognised as MUS (Medically Unexplained Symptoms, fatigue, anxiety, IBS, sleep disruption, etc.). The surprising part?

▶️ The lean symptomatic group had worse biological markers than some overweight people.

Key findings:

Higher inflammation (CRP)
Flattened cortisol rhythm (high in the evening = burnout physiology)
Increased extracellular water (a marker of stress and tissue dysfunction)
Lower skeletal muscle and cellular health (low phase angle = poorer prognosis)

Meanwhile, many overweight participants without symptoms showed better biological rhythms and tissue quality.

So what does this debunk?

That BMI alone is a good health predictor
That “normal” blood tests rule out systemic stress and inflammation
That fatigue and anxiety are always “in your head”
That more weight means worse health

This study supports what I see in clinical practice:
True dysfunction is often invisible on standard tests—and highly misunderstood.

That’s why I’m building a diagnostic and therapeutic model that doesn’t stop at weight or simple blood panels scores.
It includes:

Objective autonomic nervous system analysis
Extracellular matrix and cellular conductivity mapping
Functional brain (prefrontal cortex) evaluation
Therapies like PEMF and ozone to restore real physiology

This isn’t theory—it’s already in motion.
I’m bringing elite-level recovery and longevity care to the public.

Do you think we’re too focused on numbers like BMI instead of how the body truly functions?

Let me know in the comments.

It’s never been easier to get health advice—from online articles to AI chatbots—but how accurate is it? And more importa...
31/07/2025

It’s never been easier to get health advice—from online articles to AI chatbots—but how accurate is it? And more importantly, how much of it is truly tailored to the individual?

Take body composition. Most people associate it with weight, BMI, or body fat percentage. But real insights into health and longevity lie deeper—in the quality of your lean mass, cellular integrity, and extracellular matrix (ECM) health.

For example:

-Muscle quality, not just quantity, predicts longevity and resilience:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12067000
https://longevityandhealthspan.biomedcentral.com/articles/10.1186/2046-2395-3-9

-ECM integrity and mechanotransduction are now recognized as key regulators of aging and inflammation:
https://www.frontiersin.org/articles/10.3389/fragi.2022.935220/full
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10187690
https://www.nature.com/articles/s41467-023-44409-2

Most online or AI-driven wellness tools don’t access this level of detail. They provide risk scores or vague trends. But they rarely evaluate cellular conduction, redox state, or regulatory tissue capacity—factors that define how you age and recover.

Even advanced AI has its limits:

Recent papers showed ChatGPT-style models often hallucinate answers or references, and diagnostic accuracy varies wildly depending on question type:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10804900
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10587915

AI tools are fast—but they’re still generic. They can’t measure your autonomic nervous system flexibility, mitochondrial resilience, or cellular repair systems in real time.

I am taking a differnt approach to these analysis:

Objective, physiology-based testing
Dynamic data on redox balance and metabolic adaptability
ECM and neuromuscular function as predictive markers of resilience.

In case you are wondering, yes, you can we can analyse all of these in a point of care settings, non invasively and no need for hundreds of blood tests.

This isn’t about more information—it’s about the right information. The kind that allows for early course correction, targeted interventions, and genuine performance recovery.

Because true longevity isn’t measured in data points—it’s built in the regulatory systems that keep you adaptable, anti-fragile, and functional over time.

🧬 Inflammation Aging: What Gets Measured, Gets ManagedAs we continue shaping the future of performance and regenerative...
25/07/2025

🧬 Inflammation Aging: What Gets Measured, Gets Managed

As we continue shaping the future of performance and regenerative medicine, chronic inflammation is proving to be one of the most consistent and predictive markers of biological aging.

According to Singh Newman (2011), long-term population studies show that elevated levels of inflammatory markers like IL-6, CRP, and TNF-α are strongly associated with:

Sarcopenia physical frailty
Cognitive decline
Cardiovascular disease
Poor recovery functional limitations
Increased all-cause mortality

In short: inflammation isn’t just a response—it’s a driver of aging.

⚠️ The problem? These markers are rarely tested in routine health checks.
They fluctuate, they’re complex to interpret, and they don’t fit the reductive model of “you’re fine until you’re sick.” But the science is clear:
Even low-grade, subclinical inflammation (what many call “inflammaging”) accelerates physiological breakdown years before diagnosis.

💡 This is why new diagnostic strategies must move beyond basic panels.
We need systems that quantify and track inflammatory load, redox balance, and autonomic regulation—not just look for disease, but anticipate dysfunction.

And we need therapeutic frameworks that don’t just suppress inflammation, but rebalance the systems that regulate it.

What we’re building is rooted in this science. A new level of care—precise, proactive, and personal.

Inflammaging

🎓 Honoured, Proud, and Grateful**I’m incredibly proud to share that I’ve been granted a place at La Sapienza University ...
22/07/2025

🎓 Honoured, Proud, and Grateful**

I’m incredibly proud to share that I’ve been granted a place at La Sapienza University of Rome for the course “Ossigeno-Ozono: Principi, Meccanismi e Pratica Clinica.” 🇮🇹

This programme is one of the most rigorous academic pathways in Europe dedicated to Oxygen-Ozone Therapy—grounded in solid clinical science, precise application protocols, and a vision to elevate standards in integrative medicine.

What makes this particularly special is that, upon completion, I’ll very likely become the only practitioner in the UK holding formal university-accredited qualifications in this field.

This is more than a title. It’s a commitment—to ensuring clinical excellence, patient safety, and scientific integrity in a space that is growing fast but often lacks standardised practices.

Why does this matter?

Oxygen-Ozone Therapy is not experimental—its anti-inflammatory, antimicrobial, analgesic, and pro-regenerative effects are well-documented in international medical literature. But as its popularity spreads, so does the need for precise protocols, advanced training, and evidence-based application.

I believe in bringing the highest global standards into our day-to-day clinical work. This step is part of a broader mission: to offer regenerative, non-invasive, and intelligent care backed by science, not trends.

To all mentors, colleagues, and patients who trust the journey—thank you.
There’s much more to build, and this is a key milestone.

Onwards and upwards 🙏

OzoneTherapy

⚠️ Feeling tired, inflamed, anxious, or unwell—but your blood tests and scans say you’re “fine”?You’re not imagining it....
18/07/2025

⚠️ Feeling tired, inflamed, anxious, or unwell—but your blood tests and scans say you’re “fine”?

You’re not imagining it.
What many call “vague symptoms”, are actually well documented symptoms in medical literature (Medically Unexplained Symptoms) — fatigue, pain, spread haches and pains, GI issues, brain fog, headaches — and real signs of autonomic nervous system dysfunction and stress axis dysregulation.

But here’s the issue: traditional healthcare often looks at the body in fragments. It chases diagnoses by organ system and treats symptoms in isolation. A system that works exceptionally well in case of pathology. But what about the time we are developing the pathology.

When standard lab markers show no red flags, patients are left with a label like “psychosomatic”, “IBS,”, fibromyalgia or “chronic fatigue”, and very little help.

🔍 What if the root problem lies in how your body regulates itself?

Chronic sympathetic dominance, low-grade systemic inflammation, and maladaptation of the stress axis (HPA axis) are now known to be involved in many non-specific symptoms—even years before a disease becomes diagnosable.

If your autonomic nervous system, electrolyte balance, redox homeostasis, and cortisol rhythms are out of sync, you can’t heal properly, recover efficiently, or regulate mood, digestion, or metabolism—no matter how many supplements, peptides or meds you take.

✅ What’s needed is a functional, integrated approach:

Objective measurements of stress, inflammation, and autonomic tone.
Quantification of non-specific symptoms into real biological data.
Non-invasive tools that detect dysfunctions before disease.
Therapies that rebalance core systems, not just mute symptoms.

This model already exists—used by elite performers for years. But it’s time we made it accessible to anyone seeking real answers, not endless labels.

We’re building something disruptive. Something science-backed. Something that puts regulation, not suppression, at the center of health.
The future isn’t more meds. It’s smarter diagnostics and targeted recovery protocols that restore your physiology’s natural intelligence.

Because your body was never broken—it just needs to be decoded.

¹ Montano et al., Autonomic imbalance and disease
² Thayer Lane, The role of the autonomic nervous system in health and disease
³ Malik et al., Heart rate variability and clinical outcomes

“I feel fine” isn’t data.One of the most common things I hear in clinic—even from high performers, athletes, executives—...
11/07/2025

“I feel fine” isn’t data.

One of the most common things I hear in clinic—even from high performers, athletes, executives—is:

“I’m fine. Just tired. Stressed, maybe. But I’m used to it.”

Here’s what they don’t realise:That same system that lets you push through is the same one silently draining your reserves.

By the time symptoms show up—fatigue, inflammation, brain fog, gut issues, recurring pain—your biology has already been compensating for months, sometimes years.

We’ve built a world that celebrates grind… and penalises rest.That praises “resilience,” but rarely teaches how to recover.That equates productivity with health—until the system buckles.

What if we measured health not by symptoms, but by capacity?

How efficiently do your cells use energy?

How well does your nervous system shift between tension and restoration?

How fast do you recover from stress, both physical and emotional?

Are your immune and hormonal systems in sync, or compensating?

These are not abstract questions. We can now measure this—objectively, in real time, non-invasively.

And when we do? We no longer guess. We guide.

This is the future of precision health:Personalised, systems-based, and proactive.Not focused on treating what’s already broken—but on listening before it breaks.

And no—this level of care shouldn’t be exclusive.It should be the standard.

Stay tuned.

04/07/2025

Stress isn’t your enemy. It’s your edge.

In my years working across high performers, one truth keeps repeating itself:

“Stress isn’t the problem. It’s the chronic mismanagement of stress that is.”

Stress is activation. Adaptation. Evolution.

It’s how your system prepares to grow, respond, sharpen, and overcome.
Without it, there’s no performance. No resilience. No healing.

The issue?
We’ve forgotten how to come “down”, how to shift gears, how to REALLY recover.

Your autonomic nervous system (ANS) is built to oscillate—between stress and recovery, activation and restoration.
Not stay stuck in one mode. Not constantly accelerate without brakes.

Modern life, and modern medicine, often miss this.
People are labelled “stressed” as if it’s a diagnosis.
Given sedatives, stimulants, or supplements to mask symptoms, not restore rhythm.
But all these approaches only scratch the surface of what is really causing the issue.

Stress isn’t a disease. It’s a signal. A sign of potential.

Only when this signal is ignored, prolonged, or misunderstood it becomes pathology.

We now have the tools to listen.
To measure how well you move between effort and ease.
To catch the silent disruptions before they become dysfunction.
To map the real story behind your energy, recovery, mood, inflammation, and pain.

This is performance medicine—applied to everyone, not just athletes, because I am a strong believer that everyone of us is an athlete, everyone in different ways.

Because in the end, health isn’t about avoiding stress.
It’s about adapting to it with precision.
And recovery isn’t a luxury—it’s a skill.

Big things are coming.
Stay connected.

Your body isn’t broken. It’s misunderstood.After years working with elite athletes and high performers, one thing is cle...
02/07/2025

Your body isn’t broken. It’s misunderstood.

After years working with elite athletes and high performers, one thing is clear: dysfunction doesn’t usually start where it hurts — it starts deeper, in the way your body regulates itself.

At the heart of this is the autonomic nervous system (ANS)— the master switchboard for stress, recovery, digestion, inflammation, mood, pain, immunity, and performance. When ANS modulation is off, the whole system begins to fail… quietly, chronically, and systemically.

Science shows this clearly.¹²³ We’re not lacking medications—we’re lacking integration.
Patients are often passed from specialist to specialist, accumulating tests and diagnoses that describe symptoms — but never explain “why” they’re happening.

And treatments? Often non-specific and one-size-fits-all. Focused on parts. Not the person.

I’ve been privileged to access powerful, science-backed tools typically reserved for professional sport and high-performance medicine: real-time neurovegetative assessments, oxidative stress profiling, metabolic and cellular efficiency markers—all non-invasive, all guiding a root-cause approach.

But here’s the truth:
This shouldn’t be reserved for the elite.
Everyone deserves access to this level of precision and personalisation—especially in a time where people are sold quick fixes, vague diagnoses, and told to “just manage” their symptoms.

Especially in an era where people are chasing quick fixes, vague labels, and suppressing their body’s innate ability to heal, thrive, and perform.

We don’t need more drugs. We need better diagnostics and data.
Not more protocols — but smarter, personalised, systemic care.

I’m working—right now—on bringing this to life.
Something innovative, disruptive, and yet rooted in long-standing science.
Something that finally puts the pieces together.

Big things are coming.
Stay tuned.

¹ Montano et al., Clinical Autonomic Research
² Thayer Lane, Biological Psychology
³ Malik et al., The Lancet

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My story, Emanuele Calabrese

English

My journey towards osteopathy begins in 2011, in Rome, driven only by love for anatomy and people care. In the summer of 2015 I realise that I want more than just a Diploma, I look to an unknown osteopathic world, and I discover I can get a Degree in this beloved profession. I take my bags and leave for Saronno where I will finish my studies in 2017 obtaining the Diploma in Osteopathy and most importantly, a Bachelor of Science in Osteopathy through the British College of Osteopathic Medicine of London.

I learned that opening your eyes and always looking forward helps to grow and improve, and therefore I have not stopped, I moved to London where today I am registered with the General Osteopathic Council and I work in different clinics.

This page is meant to be a place for sharing my opinions, experiences, impressions and anything about this wonderful science, Osteopathy. Whether you are an osteopath or just a curious person, you will find this space rich of interesting topics.