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05/10/2025

🌱 Dandelion root extract shows potential in colon cancer research

In laboratory studies, an aqueous dandelion root extract (DRE) killed more than 95% of colon cancer cells within 48 hours by triggering programmed cell death. Unlike many treatments that focus on a single pathway, DRE activated both caspase-dependent and caspase-independent mechanisms. Remarkably, it was effective even in cancer cells lacking p53, a tumor-suppressor gene often mutated in aggressive cancers.

Importantly, DRE appeared selective: healthy colon cells were largely unaffected in the same experiments.

Animal studies supported these findings. In mice implanted with human colon cancer cells, oral administration of DRE slowed tumor growth by more than 90%, with little reported toxicity.

While these results are highly encouraging, they remain limited to cell cultures and animal models. Human clinical trials have not yet confirmed safety or efficacy. Further studies will be needed before dandelion root extract can be considered as a treatment option.

Source: Ovadje, P., Chatterjee, S. J., Griffin, C., Tran, C., Hamm, C., & Pandey, S. (2016). Dandelion root extract affects colorectal cancer proliferation and survival through the activation of multiple death signalling pathways. Oncotarget, 7(45), 73080–73100.\

04/10/2025

In the field of neuroprotection, one landmark preclinical paper is “Cannabinoids in experimental stroke: a systematic review and meta-analysis” (2015), which showed that cannabinoids significantly reduce infarct volume and improve functional outcomes in animal stroke models.

That tells us: the endocannabinoid system (ECS) is not just background noise in brain injury it’s a key player.

When someone suffers a stroke, the brain goes into chaos - excitotoxicity, oxidative stress, inflammation, blood-brain barrier breakdown, cell death.

To recover, you need more than one fix. That’s where cannabinoids - both the body’s own (endocannabinoids) and plant cannabinoids (phytocannabinoids) - come in as modulators and buffers.

Here’s the story, in everyday terms:

Your ECS is like a home thermostat for brain health. It monitors and adjusts neural activity, inflammation, synaptic signaling. When things go wrong—like in ischemia—you get too much glutamate, microglia go berserk, ROS damage mitochondria, the vasculature leaks, immune cells flood in.

ECS receptors (CB1, CB2, and others) can dial things down. CB1 activation helps suppress excessive neurotransmitter (especially glutamate) release, reducing excitotoxic injury. CB2 activation tempers microglial activation, directs a shift to anti-inflammatory phenotypes, and limits infiltration of peripheral immune cells.

Now add in phytocannabinoids. Take CBD for example—it doesn’t bind CB1/CB2 strongly like THC does, but it modulates ECS tone: it can inhibit breakdown of endocannabinoids, interact with PPARs, TRPV1, and other receptor systems.

That gives your body more “room” to self-regulate. In stroke recovery, these extra tools help blunt secondary damage, promote neuroprotection, and support repair. Some studies show CBD reduces inflammation, oxidative stress, and neuronal death in ischemic models.

But here’s the real key: it’s not “endocannabinoids good, phytocannabinoids better.” It’s ECS balance.

-Mike Robinson, Researcher OG

04/10/2025
29/09/2025

For the first time on Cannabis Health Radio, we’re stepping beyond cannabis to explore another powerful form of plant medicine: psilocybin mushrooms. While cannabis works through the endocannabinoid system, psilocybin acts on serotonin pathways in the brain. Together, they reveal different but equ...

20/09/2025
19/09/2025

"Your body’s own cannabinoid molecules calm you during stress" (Patel et al., 2023), and that single finding sums up why the Endocannabinoid System (ECS) is so vital to our mental health.
Deep inside the brain, this master regulator dials back overactive circuits, guiding the central nervous system back toward balance when stress and fear take over. In moments of anxiety, when the amygdala fires alarms and the body braces for fight or flight, endocannabinoids like anandamide are released to quiet the signal.
They act like natural brakes, calming excitatory neurotransmission and restoring rhythm. When the ECS is balanced, fear fades once the danger is gone, moods stabilize, and the prefrontal cortex can regain control.
But when it is out of balance, anxiety lingers, the fear response exaggerates, and the nervous system rewires itself in ways that make the problem worse.
Plant cannabinoids step in as natural allies, each guiding the system back toward equilibrium.
CBD reduces overactivity in fear-driven brain regions while enhancing prefrontal regulation.
CBG and CBC show potential in supporting neurogenesis and damping neuroinflammation that keeps circuits unstable. These compounds not only ease symptoms but also promote long-term change by encouraging neuroplasticity - the brain’s ability to rewire itself away from fear loops.
Lifestyle is just as important. A diet rich in omega-3 fatty acids builds the raw materials for endocannabinoids, while exercise boosts their release and fuels growth in the hippocampus.
Sleep restores the system, and practices like meditation or breathwork ease the chronic stress that overwhelms it.
Together, cannabinoids and healthy living create a blueprint for stabilizing mood and calming fear responses, an approach rooted in science, supported by daily habits, and powered by the body’s own master regulator, the Endocannabinoid System.
Stay Balanced.
-Mike Robinson, The Researcher OG

12/09/2025
Cbd/coconut oil/ Rso mix.
03/09/2025

Cbd/coconut oil/ Rso mix.

03/09/2025

ALS is a disease that slowly takes away control of the body while leaving the mind painfully aware of what’s happening. There is no cure, and standard treatments only slow progression without restoring function. That’s why so many patients and caregivers look toward cannabinoids like THC, CBD, and CBG for support. These compounds interact with The Master Regulator — the Endocannabinoid System — which oversees nerve health, inflammation, and muscle tone, all of which collapse in ALS.

THC provides meaningful relief from one of the most crippling symptoms of ALS: muscle spasticity. By activating CB1 receptors in the nervous system, THC helps relax rigid muscles, eases pain, improves appetite, and supports sleep. It can also reduce anxiety and depression that often come with the diagnosis, giving patients more dignity in their day to day life.

CBD adds anti-inflammatory and antioxidant power. ALS is fueled by oxidative stress and immune overactivation, both of which kill motor neurons. CBD helps calm this process while also interacting with serotonin and TRPV1 receptors to reduce pain and improve mood. It has little to no psychoactivity, which makes it an accessible tool for patients sensitive to THC.

CBG may be the most promising of all. Studies show CBG can protect neurons by acting on α2-adrenergic and CB2 receptors, calming the brain’s immune cells and reducing excitotoxicity — the nerve overfiring that accelerates ALS damage. In doing so, CBG creates a safer environment for motor neurons and may help preserve function longer.

Together, THC, CBD, and CBG form a triad that addresses ALS from multiple angles: relief from spasticity and pain, protection against oxidative stress, and support for neurons under attack. They do not cure ALS, but they bring real comfort and restore a sense of balance where medicine alone often falls short. For patients and families living through ALS, that relief is everything.

-Mike Robinson, The Researcher OG

26/08/2025

Another Case of MS Shut Down by HIV Drugs

This is the third case study I’ve shared of an MS patient whose disease activity stopped after starting antiretrovirals for HIV — and it won’t be the last.

Here’s what happened:

• Diagnosed with MS at age 24 after two relapses in four months (leg numbness + optic neuritis). MRI confirmed typical MS lesions.

• Treated with interferon-beta-1b for about 10 years. During this time he had two more relapses (upper limb numbness in 2007 and double vision in 2009). Disability score (EDSS) reached 2.0.

• In 2012, he stopped interferon on his own, saying he felt stable.

• In 2014, after a hospital visit, he was unexpectedly diagnosed with HIV.

• He started ATRIPLA® (efavirenz/emtricitabine/tenofovir disoproxil fumarate) — a daily HIV drug.

From that point forward:

🔹 No relapses
🔹 Stable MRIs (no new active lesions)
🔹 Clinically stable and fully functional
🔹 Undetectable HIV viral load and healthy blood counts 

Why is this so important?

• Antiretrovirals can block Epstein–Barr Virus (EBV), one of the strongest known triggers of MS.
• They may also suppress human endogenous retroviruses (HERVs) linked to inflammation in MS.

👉 Once again, MS activity shut down — not with standard MS drugs, but with antiretrovirals.

I’ll keep posting these cases so people can see the pattern.

At MS Hope, we are dedicated to finding out if EBV is the true driver of MS — and whether antiretrovirals can shut it do

📖 Study: “Multiple Sclerosis and Subsequent Human Immunodeficiency Virus Infection: A Case with the Rare Comorbidity, Focus on Novel Treatment Issues and Review of the Literature” (Skarlis et al., In Vivo, 2017). https://pmc.ncbi.nlm.nih.gov/articles/PMC5656849/

26/08/2025

Post-Traumatic Stress Disorder isn’t just about memories — it’s about how the nervous system gets rewired after trauma. The brain starts treating normal life like it’s a battlefield, keeping people locked in fight-or-flight, unable to fully rest, trust, or feel safe. Standard treatments — SSRIs, sedatives, therapy — work for some, but too often they fall short or pile on side effects. That’s why more eyes are turning to cannabinoids and the body’s own Endocannabinoid System (ECS), the Master Regulator that directly controls stress circuits, memory extinction, and emotional balance.

Cannabinoids like THC, CBD, and CBG interact with the ECS in ways that matter deeply for PTSD. CB1 receptors in the brain regulate fear learning and memory extinction — the ability to stop reliving traumatic events. A 2014 study titled “Cannabinoid regulation of fear and anxiety: an update” (Neuropharmacology, 2014) showed that CB1 activation helps reduce conditioned fear responses and promotes extinction of aversive memories. This is why THC, in the right dose, can interrupt nightmares and flashbacks — it literally helps the brain stop replaying trauma.

CBD works differently. It modulates serotonin signaling, calms overactive amygdala circuits, and reduces hypervigilance without intoxication. A study published in Frontiers in Neuroscience (2018) reviewed how CBD reduces anxiety and improves sleep - two of the biggest pain points for people with PTSD. Meanwhile, minor cannabinoids like CBG and CBC add anti-inflammatory and neuroprotective effects, helping heal the underlying stress damage at a cellular level.

Patients often report that cannabis helps them “feel normal” - to sleep through the night, eat, and get through daily tasks without being ambushed by panic. But it’s not about numbing. When balanced right, cannabinoids help the ECS reestablish tone so the nervous system can reset instead of staying locked in survival mode.
@
The OG takeaway? PTSD isn’t just a mental health issue; it’s a system stuck in imbalance. Cannabinoids don’t erase trauma, but they help the brain and body learn how to stop reliving it. They open the door for healing, therapy, and connection to actually stick. The Master Regulator holds the key - cannabinoids are simply giving it back its rhythm.

-Mike Robinson, The Researcher OG

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