07/05/2026
A quick but important message from me this week…
I’m seeing more women using GLP-1 medications like Mounjaro alongside HRT but many haven’t been told how these treatments can interact.
GLP-1s slow gastric emptying which may reduce how well oral progesterone is absorbed.
Progesterone plays a crucial role in protecting the womb lining when you’re taking oestrogen. If levels aren’t adequate, the lining can thicken over time which isn’t something we want to miss.
This doesn’t mean stopping treatment. It means reviewing it.
In some cases, using a non-oral form of progesterone may provide more reliable protection while on a GLP-1.
If you’re on both, it’s worth checking in:
Are you on the right type and dose of progesterone?
Do you have a plan for follow-up?
Good care should always be joined-up and individualised.
NHS GP & certified Lifestyle Medicine Physician