23/10/2025
Cardiovascular diseases (CVDs) remain the leading cause of mortality globally. Despite advancements in medical treatments, the heart’s intrinsic regenerative capacity is limited, particularly following myocardial infarction (MI). Stem cell-based therapies have emerged as a promising approach to repair and regenerate damaged cardiac tissue. However, challenges such as poor cell survival, limited engraftment, and inadequate functional integration hinder their clinical application. Biomaterials have been identified as critical components in enhancing stem cell therapy by providing a supportive microenvironment that promotes cell survival, differentiation, and tissue integration.
