Immunotherapy in Germany - Innovative Approach in Cancer Treatment

03/06/2025

"While glioblastoma is not considered a curable condition, Ms Ackroyd said her husband has shown an "absolutely remarkable" improvement and the tumour has reduced."

"Now we're sort of living some sort of normal-ish life again. We can socialise with friends and go and see our daughter in a school play."

"If we relied on the NHS, my husband would not be here now."

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The BBC recently reported on the case of Steve Ackroyd from North London, who was diagnosed with glioblastoma in 2022. The link to the original text below.

Steve Ackroyd is undergoing private treatment abroad for his inoperable brain cancer.

25/01/2025

We encourage you to read the story of Dallas Carroll, a young mother who was diagnosed at the age of 29 with stage 4 breast cancer with metastases to her bones and liver. Dallas was told that with standard treatment, her prognosis would be between 5 and 7 years. However, she chose a personalized treatment supplemented with a dendritic cell vaccine.

After six doses, Dallas’s breast tumor shrank from 80 millimeters to 11 millimeters. Some of the bone metastases showed signs of healing, and the liver lesions also decreased in size. Since she responded so well, Dallas began a second round of eight vaccinations in May 2024.

Scans after the second round of vaccines showed further disease reduction and the complete disappearance of a metastasis in her spine. At the end of June, she began chemotherapy, hoping that her previous immune response would make the treatment more effective.

The dendritic cell vaccine, as part of IMI (Individual Multimodal Immunotherapy), is available at the IOZK Clinic in Cologne, Germany.

Link to the full article below.

31/12/2024

All The Best In The New Year!

30/08/2024

Patients often ask what oncolytic viruses are and how they work in fighting cancer. Below, we present some of the most important facts and conclusions from independent studies conducted by doctors & scientists, as well as from the clinic's website. It turns out that the anti-cancer properties of oncolytic viruses are being actively studied in many research institutions around the world.. I encourage you to read the attached articles (links in comments).

Information from the clinic's website:

Viruses are known to cause many diseases. A lesser-known fact is that some viruses can be used in cancer treatment. Over 100 years ago, doctors first observed that patients were cured of cancer after contracting an infectious disease. Systematic research has shown that there are viruses that selectively attack cancer cells. These are called oncolytic viruses. In October 2015, the first oncolytic virus was approved in the USA, and later in Europe and Australia in 2016, for the treatment of malignant melanoma.

Cancer cells cannot defend themselves against viruses

Cancer cells are particularly susceptible to viral attacks because, unlike healthy cells, they cannot produce enough interferon to defend themselves. Therefore, viruses can freely replicate within cancer cells. This, in turn, alerts the immune system, leading to an immune response against cancer cells throughout the body. Healthy cells prevent virus replication by producing interferon and are therefore not damaged, making virus treatment virtually free of side effects.

Newcastle Disease Virus

The Newcastle Disease Virus, used in cancer treatment at IOZK, is one such oncolytic virus. It has been used for decades and has been particularly well-studied for its effectiveness in fighting cancer.

Conclusion from the article by Iranian scientists published in 2023 (link in the comments):

This review highlights the growing role of oncolytic virotherapy using the Newcastle Disease Virus (NDV) in cancer treatment, emphasizing its ability to selectively replicate in cancer cells, induce immunogenic cell death, and influence signaling pathways related to oncogenesis, supported by numerous in vivo and in vitro studies.
Numerous clinical studies on NDV have been conducted, evaluating its safety, efficacy, and application in complex cancer treatment strategies. Despite these advances, many challenges remain, such as the mechanisms by which cancer cells evade the immune response, tumor heterogeneity, and tailoring treatment options to the specific characteristics of the tumor. Moreover, NDV-based therapies require careful consideration of regulatory and commercialization issues to become widely accessible and accepted.

The potential of NDV in cancer therapy is significant. The combination of oncolytic virotherapy, immunogen-induced cell death, and modification of oncogenesis-related signaling pathways forms the core of this innovative approach. However, it should be remembered that the clinical implementation of NDV-based oncolytic virotherapy may encounter challenges such as optimizing delivery methods, counteracting potential side effects, and ensuring safety and efficacy in humans, requiring further research and development. NDV-based therapies are expected to revolutionize cancer treatment, improve patient outcomes, and enable more personalized and precise cancer therapies through continued research, collaboration, and overcoming future challenges.

Conclusion from the article from dr Greg Delgolffe of the University of Pittsburgh School of Medicine from October 2023 (link in comments):

One of the most important findings in cancer research in the past two decades is that tumors can create force field-like protection against the immune system. A new study has identified a way to break through that force field to improve cancer treatment, by taking advantage of a virus that can specifically infect cancer cells.

One oncolytic virus, an immunotherapy called T-VEC, has been approved by the Food and Drug Administration (FDA) for the treatment of metastatic melanoma. Oncolytic virus therapies for additional types of cancer have yet to be approved, although several are being tested in clinical trials.

In the new study, funded in part by NCI, Greg Delgoffe, Ph.D., of the University of Pittsburgh School of Medicine, and his colleagues created a modified oncolytic virus that can transport the genetic instructions for a potent cancer treatment directly into cancer cells.

To use the immune system to kill cancer, as is the case with immune checkpoint inhibitors, you need to block immune-suppressing signals, Dr. Delgoffe emphasized. This new oncolytic virus approach is a way to “turn the tide,” he said, and “convert a resistant tumor into a sensitive one.”

You can reach us and ask questions under 07547 901434.

Bart Kinas
bart@kinasconsulting.org

It can be said that until December 31, 2017, we were an average Polish family, leading a fairly happy life in exile in England. In the morning we had no idea

02/02/2024

Recently, an article titled "Fought Path to Life - Immunotherapy as a Ray of Hope" was published on the German website gesunder-koerper.info, in which 25-year-old Jasper Maes, diagnosed with glioblastoma multiforme, shares how comprehensive immunotherapy at a clinic in Cologne helps him fight the most malignant opponent.

Below is the English translation of the article and the link to the original publication in German:

"Fought Path to Life - Immunotherapy as a Ray of Hope

At the age of 25, Jasper Maes was diagnosed with glioblastoma - a malignant brain tumor. In an interview, the young man tells why he decided on immunotherapy in Germany and how he feels now.

Were there any symptoms that indicated you might have cancer?

I was lucky or unlucky not to experience any symptoms - until my body went into "shutdown mode." The pressure in my head caused not only headaches but also nausea, vomiting reflexes, and vomiting. That's why I was transported to the intensive care unit, where a malignant brain tumor was diagnosed. A few days later, I underwent urgent tumor removal surgery. The terrible news that it was glioblastoma multiforme came after the biopsy.

What was your reaction to such a difficult diagnosis?

I was completely stunned and could barely believe it. I immediately asked myself what I had done wrong in life to get sick that badly. After all, I was always active and took care of my health: I don't smoke ci******es, and I only drank alcohol occasionally. After the diagnosis, I immediately stopped doing it. I wanted to find a way to cure.

Did you search for various treatment options on the Internet yourself or did you consult with a doctor?

I tried to search the internet for stories of people who survived a disease similar to mine. I was looking for positive relations. However, I usually stopped after a few Google searches because the information I found about glioblastoma was more depressing than motivating. In addition to conventional treatment with radiotherapy and chemotherapy, I first sought a second opinion at another hospital.

You live in Belgium and decided on immunotherapy in Germany. Why?

Through a friend of my father, we were contacted with a researcher at the University of Antwerp who recommended a cancer specialist in Germany. The doctor gave me some hope by talking about his successful attempts with immunotherapy. Although there was no guarantee of success, I felt that I should try and I had nothing to lose.

Can you describe the immunotherapy you decided on?

With conviction in the decisive role of my own immune system in the fight against the tumor, I not only actively worked on strengthening it but also tried immunotherapy. It includes modulated electrohyperthermia therapy combined with administration of the Newcastle disease virus. This involves weakening cancer cells by heating them using EHT technology, allowing the oncolytic virus to attack and destroy them.

I started this therapy in parallel with conventional chemotherapy. In the second part of the treatment, a dendritic cell vaccine is produced from my extracted blood to stimulate my own immune system to fight cancer cells.

How do you feel today?

Given my situation and the disease I had to fight and still fight, I couldn't be better. I am very happy that I started immunotherapy because I really feel that it has made a big difference in my fight against cancer. I firmly believe that an active and healthy lifestyle increases the chances in the fight against this terrible disease. However, I still have a great fear of relapse and live very cautiously. But I am extremely lucky and happy to be where I am today. I try more and more to return to "normal" life."

Interested individuals are encouraged to ask questions about therapy here.
Email: bart@kinasconsulting.org
Tel./Whatsapp: +44 7547 901 434

Im Alter von 25 Jahren wurde bei Jasper Maes die Diagnose Glioblastom, ein bösartiger Hirntumor, gestellt. Im Interview teilt der junge Mann mit, warum er sich für eine Immuntherapie in Deutschland entschieden hat und wie es ihm heute geht. Gab es Anzeichen, dass Sie Krebs haben könnten? Ich hatt...

19/01/2024

Short update for those interested in the interview with Prof. Van Gool.
Our recently released material had a technical issue - the sound was recorded in mono, so it was only audible in one earphone/speaker.
Today, we have uploaded the new, corrected version in stereo (see link below).
We encourage you to check out the content where I asked the main oncologist at the IOZK clinic the most frequently stated questions by You.

Especially for you, I interviewed the chief oncologist at the IOZK clinic in Cologne, where I asked the most frequently asked questions.(Stereo Version)Below...

12/01/2024

Find Us On YouTube!
On our channel we have just released previously announced interview with the main oncologist of the IOZK clinic in Cologne.
All your most frequently asked questions were answered.
The timestamps list is attached with the video for easier navigation between questions.
Below you can find the link to the FB post that includes the video.
In case of any further questions please contact us directly. 📸 Look at this post on Facebook https://www.facebook.com/share/AgJNuM7CizCCNzYH/?mibextid=WC7FNe

30/12/2023

Below you will find the previously announced interview with the chief oncologist of the IOZK clinic in Cologne, in which I asked the most frequently stated questions by you. I am also attaching a list of these questions with timestamps for easier navigation. Feel free to familiarize yourself with the material. If you have any further questions, I am available.
Bart Kinas
Email: bart@kinasconsulting.org
Tel/Whatsapp: +44 7547 901 434

0:00 – Introduction
0:58 – What method of cancer treatment is offered at the clinic and what does it involve?
4:29 – What is dendritic cell vaccination, and how does it work?
7:45 – More about the Nobel laureate for the discovery of dendritic cells, R. Steinman
11:41 – Is the IOZK clinic the only place in Europe where dendritic cell vaccination is available?
14:26 – Are there scientific studies confirming the effectiveness of this therapy?
18:20 – Is the therapy effective, and does the clinic have its own statistics?
21:49 – Can the therapy be used for all types of cancer?
24:24 – Can this treatment be combined with radiotherapy and chemotherapy? Do the clinic's doctors collaborate with physicians in Poland? 27:18 – Is the therapy safe? What side effects does it cause?
28:49 – What is the treatment schedule, and how long does the therapy last?
31:24 – How much does the therapy cost?
35:01 – Ending