27/01/2026
New research from the University of Cambridge, highlighted this week by the British Menopause Society, is getting attention for linking menopause with changes in brain structure, mood and sleep.
Published in Psychological Medicine, the study analysed data from 125,000 women in the UK Biobank and found:
🧠 Reductions in grey matter volume in key brain regions after menopause
🧠 Increased anxiety, depression and sleep disturbance
🧠 Slower reaction times with ageing and menopause — which HRT appeared to slow
Before this becomes a headline to worry about, some really important context:
This study does not say menopause causes Alzheimer’s disease.
It does not say HRT increases dementia risk.
It does not suggest women should avoid HRT.
What it does do is validate what many women say in clinic every day:
“I don’t feel like myself cognitively.”
“My sleep is awful.”
“My mood is all over the place.”
These symptoms are real. Measurable. Biologically linked to hormonal change.
Interestingly, whilst HRT did not appear to alter grey matter findings, we know from strong existing evidence that HRT remains highly effective for mood, sleep and quality of life for many women.
The authors emphasise the importance of:
✨ Sleep hygiene
✨ Healthy lifestyle
✨ Mental wellbeing in midlife
✨ Open conversations about cognitive symptoms
This isn’t a story to fear.
It’s a story to understand.
And a reminder that menopause care must include brain health, not just hot flushes.
Menopause is linked to reductions in grey matter volume in key brain regions as well as increased levels of anxiety and depression and difficulties with sleep,