18/12/2024
Not only selenium and iron but also zinc deficiency may be linked with thyroid autoimmune diseases. Zinc may have regulatory effects on thyroid hormones and it plays a key role in the metabolism of thyroid hormones, specifically
by regulating:
🔹 deiodinase enzyme activity
🔹thyrotropin-releasing hormone (TRH)
🔹thyroid stimulating hormone (TSH) synthesis
and by modulating:
🔹the structures of transcription factors involved in the synthesis of thyroid hormones.
Zinc concentrations may affect:
🔹T3, T4 and TSH levels
Zinc transporters are present in the hypothalamus, pituitary, and thyroid.
Remember:
📌 Micronutrients are essential for normal thyroid function. It is important to consider micronutrient deficiencies (selenium, iron, and zinc) in case of thyroid dysfunction.
Vargas-Uricoechea H, Urrego-Noguera K, Vargas-Sierra H, Pinzón-Fernández M. Zinc and Ferritin Levels and Their Associations with Functional Disorders and/or Thyroid Autoimmunity: A Population-Based Case-Control Study. Int J Mol Sci. 2024.
Severo JS, Morais JBS, de Freitas TEC, Andrade ALP, Feitosa MM, Fontenelle LC, de Oliveira ARS, Cruz KJC, do Nascimento Marreiro D. The Role of Zinc in Thyroid Hormones Metabolism. Int J Vitam Nutr Res. 2019.