16/09/2023
Oral Corticosteroids for Asthma
OCS stands for oral corticosteroid. This means the medication is swallowed and distributed throughout your body, not just your airways. A corticosteroid is a medication that decreases your body’s inflammatory response. They are used for treating many conditions. You may be prescribed an oral corticosteroid for asthma, chronic obstructive pulmonary disease (COPD), or allergic reactions. Another term for OCS is “glucocorticoid”. Oral corticosteroids may be referred to as “rescue medication” or “steroid tablets”.
An oral corticosteroid may be given in the form of a pill, a liquid, or even intravenously if you are in the hospital. You will usually take this medication for 5-10 days. Children will take OCS medication for a shorter period of time. Types of oral corticosteroids include: Prednisone, methylprednisolone, hydrocortisone
Who uses OCS?
Most people with asthma do not use oral corticosteroids as part of their treatment plan. Oral corticosteroids can be used to treat uncontrolled asthma or in some cases, severe asthma. Oral corticosteroids may also be used in the emergency department when urgent treatment is needed, during or just after an asthma attack. If you have severe asthma, you may be prescribed oral corticosteroids long-term. Your healthcare provider will only prescribe oral corticosteroids if it is absolutely necessary to prevent you from having severe or uncontrolled asthma symptoms.
Approximately 30% of adults with severe asthma are considered corticosteroid-dependent, meaning that chronic OCS are required in addition to inhaled corticosteroids (ICS), and other controllers to achieve and maintain control of their asthma.
ICS vs. OCS
Your healthcare provider may have prescribed you an inhaled corticosteroid (ICS). ICS are the most effective anti-inflammatory medications for asthma. Inhaled corticosteroids are taken through an inhaler or nebulizer.
ICS reduce symptoms, increase lung function, quality of life, and reduce the risk of exacerbations and asthma-related hospitalizations or death. These medications are delivered into the lungs and are not designed to circulate throughout your body. There are specific corticosteroids designed for inhalers and these medications are different than the OCS. Types of inhaled corticosteroids include Beclomethasone, budesonide, ciclesonide, fluticasone propionate, fluticasone furoate, mometasone, triamcinolone
ICS Inhaled corticosteroids are taken through an inhaler or nebulizer. The medication is inhaled directly into your lungs and airways. Inhaled corticosteroids are a maintenance treatment for asthma. ICS are taken daily to maintain asthma control for 12-24 hours. ICS treats your lungs and airways only, so the medication does not distribute throughout your body. This means you do not experience harmful side effects that can occur with OCS.
OCS - Oral corticosteroids are taken by pill or even sometimes intravenously to treat severe asthma symptoms or exacerbation. The medication travels through the bloodstream and affects other parts of your body. OCS are typically taken as a short-term medication (5-7 days) for severe, acute asthma symptoms, but can sometimes be used more frequently to treat severe asthma. OCS enter other systems in your body, not just the lungs, so your body is exposed to more medication and there is a higher risk of severe side effects.
Benefits and Risks of Oral Corticosteroids
For decades, OCS have been an important treatment for managing severe asthma, uncontrolled asthma, and acute asthma exacerbations (attacks) in children and adults. However, prolonged use of OCS has severe health implications. OCS use has a cumulative effect on a person over their lifetime, and relying on this form of treatment can cause significant health effects. Even short-term low-dose use of OCS (under 30 days) can result in serious health problems, including:
Fluid retention
High blood pressure
Problems with mood swings, memory, behavior, and other psychological effects
Upset stomach
Weight gain
Longer-term effects include:
Cataracts/glaucoma
Trouble sleeping/disruption of your sleep cycle
Depression, mood disturbances, irritability
High blood pressure (hypertension)
Adrenal suppression (suppression of your body’s stress response) Weight gain
Increased appetite
Heartburn (acid reflux)
Bone loss (osteoporosis)
Thinning of the skin/skin tears/bruising
OCS can be an important and necessary tool for some people with asthma to manage their asthma. However, it is crucial that this treatment be carefully managed, monitored, and supported by an asthma specialist or healthcare provider who specializes in asthma. If you need more than two courses/prescriptions of oral corticosteroids in a year, this is a sign that your asthma is uncontrolled. It is important that you speak with your healthcare provider right away to determine ways to improve your asthma control.
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