03/10/2025
Kintampo Health Research Centre, Research and Development Division of Ghana Health Service Contributes to Malaria Vaccine Policy.
On Wednesday, the World Health Organization (WHO) Reaffirmed the importance of a Fourth Dose of Malaria Vaccines for Children. The WHO Strategic Advisory Group of Experts on Immunization (SAGE) and the Malaria Policy Advisory Group (MPAG)’s recommendations were made following a review of KHRC-led research in Ghana, Kenya and Malawi.
The research, which used a case-control approach, was conducted under the Malaria Vaccine Implementation Programme (MVIP) among children under five and showed that the four-dose malaria vaccine schedule reduced severe malaria cases by about 54% over the study period. It also found that children who received the fourth dose of the vaccine had about 30% additional protection against severe malaria than those who received only three, with no evidence of malaria rebound among those who missed the final dose.
To improve uptake, SAGE further recommends that countries align the timing of the fourth malaria vaccine dose with other routine vaccinations and child health interventions offered in a child’s second year of life to help ease delivery challenges.
The case-control study was funded by the European and Developing Countries Clinical Trials Partnership (EDCTP) and carried out by a global consortium including the Kintampo Health Research Centre, European Vaccine Initiative (EVI), the London School of Hygiene & Tropical Medicine, African Research Collaboration for Health Limited in Kenya, Kenya Medical Research Institute (KEMRI), the University of Malawi's College of Medicine, and PATH.
Read more: https://www.kintampo-hrc.org/pages/khrc-contribution-to-malaria-vaccine.html