Medical & Physiology News

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13/04/2026

POV: Me vs DNA polymerase 🧬
That enzyme is doing the most while I can barely reply to texts 💀

Is the CDC Vaccine Schedule Linked to the Autism Surge? 📊A groundbreaking new peer-reviewed study by Mawson and Jacob ha...
07/04/2026

Is the CDC Vaccine Schedule Linked to the Autism Surge? 📊
A groundbreaking new peer-reviewed study by Mawson and Jacob has just been released, and the data is stunning. By analyzing Florida Medicaid records for children followed from birth to age 9, researchers found a clear "dose-response" relationship between the number of vaccine visits and neurodevelopmental disorders.

Key Highlights from the Study:

Autism Risk: Children with 11+ vaccine visits showed a 4.4x higher risk (Relative Risk) compared to those with minimal visits.

Population Impact: The study estimates that nearly 80% of autism cases and 85% of learning disabilities in the studied group are attributable to the vaccination schedule.

The Data Gap: Despite these findings, the NIH continues to refuse a formal, large-scale study comparing the total health outcomes of vaccinated vs. unvaccinated children.

We need transparency in public health. It’s time for an honest, independent comparison of health outcomes to ensure the safety of our children.

Read the full analysis here: [kirschsubstack.com/p/new-study]

🚨 Are we looking at a retraction crisis in academic publishing?A recent bibliometric analysis looked at 46,000+ retracti...
05/04/2026

🚨 Are we looking at a retraction crisis in academic publishing?

A recent bibliometric analysis looked at 46,000+ retractions across 10 major publishers (like Elsevier, Wiley, and Springer Nature) over the last few decades. Here is what the data uncovered:

📉 The Major Finding: More than half of all retracted papers originate from China-affiliated authors.
📊 Publisher Differences: Retraction rates aren't equal. They vary wildly from roughly 4 per 10,000 papers (Elsevier) up to 320 per 10,000 (Hindawi).
🛑 The Root Cause: This isn't just about individual misconduct. It points to massive systemic pressures—specifically the intense "publish-or-perish" culture and the booming industry of fraudulent "paper mills."

The real danger is that these retracted papers don't just disappear; they often continue to be cited, polluting future research and downstream applications.

Safeguarding the integrity of the scholarly record has never been more important. What steps do you think the academic community needs to take to fix this? Let's discuss in the comments! 💬👇
Via- chemistryworld.com

The "Invisible Labor" of Science: New Data Quantifies the Credit Gap.When a breakthrough medical paper is published, the...
31/03/2026

The "Invisible Labor" of Science: New Data Quantifies the Credit Gap.
When a breakthrough medical paper is published, the authors are celebrated. But who actually performed the work that made that breakthrough possible? A massive new study has finally quantified what many researchers have felt for decades: a persistent gender gap in academic attribution.
This analysis, which tracked data from over 128,000 researchers, shows that the labor of women scientists is systematically undercredited.
📊 The Hard Numbers:
Scientific Articles: Women who contributed to a research project are 13% LESS LIKELY to be named as authors on the resulting scientific publications than their male colleagues.
Patents: The disparity is even wider for innovation and intellectual property. Women are 59% LESS LIKELY to receive patent credit for projects they worked on.
Early Career Impact: This isn’t just an issue at the senior level. The discrepancy begins in graduate school, meaning female students are already missing out on critical publication credits.
🔬 Our Physiology Perspective: This occurs across all scientific fields, including biology and medicine where women are the majority. The gap often stems from who is prioritized for the final publication credit versus who manages the labor-intensive, behind-the-scenes tasks of data organization and foundational bench work. Historically, we saw this with Rosalind Franklin; today, the data shows the system still struggles with equitable recognition.
🗣️ Let's Discuss: To the researchers, grad students, and scientists in our community—how do we change lab culture to ensure everyone gets the credit they earn? Have you experienced or witnessed this disparity? Share your thoughts below. 👇

Potentiating CAR-T cell function in the immunosuppressive tumor microenvironment by inverting the TGF-β signal.The newly...
17/02/2025

Potentiating CAR-T cell function in the immunosuppressive tumor microenvironment by inverting the TGF-β signal.
The newly designed TB15 ICR modified CAR-T cell strategy can not only block TGF-β signal but also enhance anti-tumor function by IL-15 signal stimulation. Compared with traditional dnTβRII that block TGF-β, TB15 ICR-modified CAR-T cells showed superior anti-tumor efficacy and equal safety in a TGF-β-rich solid tumor treatment.
https://www.cell.com/molecular-therapy-family/molecular-therapy/abstract/S1525-0016(24)00813-X

Early downmodulation of tumor glycolysis predicts response to fasting-mimicking diet in triple-negative breast cancer pa...
14/02/2025

Early downmodulation of tumor glycolysis predicts response to fasting-mimicking diet in triple-negative breast cancer patients.
In brief, Vernieri et al. conducted a pilot, randomized phase 2 trial showing that cyclic FMD plus preoperative chemotherapy results in excellent pCR rates in stage I–III TNBC patients. In tumors achieving pCR, bulk and single-cell RNA-seq analysis revealed early downmodulation of glucose metabolism in TNBC cells and in glycolytic intratumor cells.
https://www.cell.com/cell-metabolism/fulltext/S1550-4131(24)00450-9

Menin orchestrates macrophage reprogramming to maintain the pulmonary immune homeostasis.Pulmonary alveolar proteinosis ...
12/02/2025

Menin orchestrates macrophage reprogramming to maintain the pulmonary immune homeostasis.
Pulmonary alveolar proteinosis is associated with impaired development and function of AMs. Zhu et al. demonstrate that deletion of Men1 leads to spontaneous PAP through epigenetic inactivation of CSF2. Menin is a critical scaffold component needed for SETD2 to catalyze H3K36me3 reactions in AMs.
https://www.cell.com/cell-reports/fulltext/S2211-1247(24)01570-5

Anatomical, subset, and HIV-dependent expression of viral sensors and restriction factors.George et al. profile viral se...
10/02/2025

Anatomical, subset, and HIV-dependent expression of viral sensors and restriction factors.
George et al. profile viral sensor and restriction factor (VISOR) expression in tissues of people with HIV. Tissue- and subset-dependent VISOR expression was observed, with the highest expression within the mucosa. In vitro, HIV enters CD4+ T cells but not myeloid cells exhibiting a permissive state, and pre-infection upregulation of VISORs is required for restriction.
https://www.cell.com/cell-reports/fulltext/S2211-1247(24)01553-5

IMPDH2 dephosphorylation under FGFR signaling promotes S-phase progression and tumor growth.Zhou et al. found that CDK1 ...
08/02/2025

IMPDH2 dephosphorylation under FGFR signaling promotes S-phase progression and tumor growth.
Zhou et al. found that CDK1 can phosphorylate IMPDH2 and suppress its basal enzymatic activity and allosteric regulation. FGFR signaling activation promotes PP2A-mediated dephosphorylation of IMPDH2 and thereby enhances guanine nucleotide synthesis for DNA synthesis and cell proliferation. Consequently, elevation of IMPDH2 activity by FGFR activation contributes to tumor cell growth.
https://www.cell.com/cell-reports/fulltext/S2211-1247(24)01467-0

MAPK14/p38α shapes the molecular landscape of endometrial cancer and promotes tumorigenic characteristics.Using unbiased...
06/02/2025

MAPK14/p38α shapes the molecular landscape of endometrial cancer and promotes tumorigenic characteristics.
Using unbiased CRISPR-Cas9-based genetic screens, Joseph et al. identify MAPK14/p38α as a dependency and vulnerability of high-grade endometrial cancer (HGEC) metastatic spheroids. MAPK14/p38α critically programs the phosphoproteome, transcriptome, and metabolome of HGEC spheroids, promoting cancer stemness and tumorigenicity.
https://www.cell.com/cell-reports/fulltext/S2211-1247(24)01455-4

The emerging role of dysregulated propionate metabolism and methylmalonic acid in metabolic disease, aging, and cancer.I...
05/02/2025

The emerging role of dysregulated propionate metabolism and methylmalonic acid in metabolic disease, aging, and cancer.
In this review, Shafer et al. shine a light on propionate metabolism, summarizing evidence that the alteration of this pathway and associated metabolites are involved in the development of various metabolic diseases and link aging to cancer progression and metastasis.
https://www.cell.com/cell-metabolism/fulltext/S1550-4131(25)00005-1

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