Dr Shambo Samrat Samajdar MD DM- Clinical Pharmacology

10/08/2025

🌟 Thrilled to have been part of an engaging panel discussion on obesity management and the evolving role of Semaglutide 2.4 mg!

I had elaborated two important clinical angles:

💡 Impact on Body Composition:

Traditional weight loss approaches often lead to significant lean mass loss — sometimes over 25% of total weight lost — impacting metabolism, strength, and function.

Semaglutide 2.4 mg changes the game:

✅ Greater reduction in fat mass vs. lean mass
✅ Increase in lean mass proportion, improving the fat-to-lean ratio
✅ Supports metabolic health and functional capacity while achieving meaningful weight loss

⏱ Practical Guidance for Missed or Intolerated Doses:

- Missed dose? Take within 5 days; otherwise skip and resume on schedule.
- Missed >1 dose? Restart at a lower dose to minimize side effects.
- Dose intolerance? Pause escalation or step down temporarily before re-escalating.

This evidence-based approach ensures better patient safety, improved tolerability, and sustained treatment success — moving us closer to personalized obesity care.

09/08/2025

Happy Raksha Bandhan! 🌸

Today we celebrate not just a festival of siblings, but the Infinite Thread of love, faith, and protection that binds souls beyond birth, gender, or distance. As in the timeless bond of Krishna and Draupadi—where a small act of compassion unfolded into infinite grace—let us remember that true rakhi is tied with the heart, not just the hand. May every thread you tie this year unite destinies, protect with love, and connect us to the Divine within.

Read our full article “The Infinite Thread: Raksha Bandhan and the Grace of Divine Bonds” published in TOI Speaking Tree today 👉 [https://timesofindia.indiatimes.com/speaking-tree/daily-ecstasy/the-infinite-thread-raksha-bandhan-and-the-grace-of-divine-bonds/articleshow/123205527.cms]

Daily Ecstasy News: Raksha Bandhan, beyond a sibling festival, embodies profound love transcending boundaries. The tale of Krishna and Draupadi illustrates this, where Dr

09/08/2025

https://youtu.be/DfJvLX_D4Bc?si=WGpJhF8s5BSziQz_

🌊 Beat the Metabolic Tsunami with RAMA! 🌿

The simple yet powerful lifestyle mantra — RAMA — to protect your gut, metabolism, and overall well-being:

R – Right Eating at the Right Time: Balanced, fiber-rich, antioxidant-packed meals with fermented foods to nourish gut bacteria.
A – Activity: Daily exercise or yoga to boost energy and gut diversity.
M – Mindfulness & Mental Well-being: Meditation and stress management to calm inflammation and protect your microbiome.
A – Adequate Sleep: Rest deeply to align circadian rhythms and maintain microbial balance.

✨ Ancient wisdom meets modern science. Follow RAMA, restore your health, and ride above the metabolic wave!

🌊 Beat the Metabolic Tsunami with RAMA! 🌿The simple yet powerful lifestyle mantra — RAMA — to protect your gut, metabolism, and overall well-being:R – Righ...

08/08/2025

🔬📉 Unraveling the Dual Burden of Diabetes and Obesity in South Asia: A Precision Medicine Roadmap 🇮🇳🌏

📢 New Review Published!
In our latest article in the International Journal of Diabetes and Technology, we explore the intersecting epidemics of obesity and diabetes (diabesity)—with a spotlight on South Asian populations and the "thin-fat" phenotype.

🧬 Key Insights:

- South Asians face early-onset insulin resistance and metabolic risk at lower BMIs due to visceral adiposity and ectopic fat.
- Adipose dysfunction, chronic inflammation, and β-cell exhaustion are central to diabesity’s pathophysiology.
- Standard BMI cut-offs are insufficient for diagnosis—we advocate for visceral fat-focused assessments using DXA (when accessible), and waist circumference.

⚙️ Innovative Approaches:

- Digital health tools (CGMs, AI-powered apps, wearables) are revolutionizing real-time monitoring and personalized care.
- Next-gen pharmacotherapy: GLP-1 receptor agonists, tirzepatide (dual incretin), and SGLT-2 inhibitors show promise in dual glycemic and weight management.
- Emerging therapies: electroceuticals, stem cell interventions, and hydrogels offer a glimpse into future metabolic care.

🏥 Policy & Equity Matters:

We call for AI-integrated, system-wide strategies to ensure equitable access, especially in LMICs like India, by addressing digital divides, food systems, and healthcare infrastructure.

💡 Conclusion: Diabesity care must evolve beyond one-size-fits-all. The fusion of precision medicine, public health equity, and technology is key to tackling this epidemic in high-risk regions.

📄 Read the full article: https://journals.lww.com/ijdt/fulltext/2025/07000/unraveling_the_dual_burden_of_diabetes_and.2.aspx

06/08/2025

📢 New Publication Out Now!

Bridging Innovation and Access: Insights from Advanced Technologies and Treatments for Diabetes 2025 and the Indian Blueprint for Diabetes Technology

📰 International Journal of Diabetes and Technology

📅 Published: August 7, 2025 | Vol. 4, Issue 3

To read the full paper click on the following :
🔗 https://journals.lww.com/ijdt/fulltext/2025/07000/bridging_innovation_and_access__insights_from.4.aspx

🔍 What the article Covers

This comprehensive review analyzes breakthrough diabetes technologies from ATTD 2025, including:

🚀 Automated Insulin Delivery (AID) systems
📈 AI-driven continuous glucose and ketone monitoring (CGM/CKM)
🧠 Digital therapeutics and decision support tools
🧬 Beta-cell replacement therapies
With India as a policy case study, the paper introduces a structured Adoption Readiness Score (ARS) and a 5-tier roadmap to evaluate how innovations can be scaled across low- and middle-income countries (LMICs).

💡 Key Contributions

✅ Policy Frameworks – India’s AI Sandbox, Ayushman Bharat Digital Mission, and regulatory reforms show scalable pathways for LMIC adoption.
✅ Equity Lens – The study foregrounds health disparities and proposes solutions to democratize access to emerging diabetes care tools.
✅ Implementation Science – From cost-effective CGMs to youth-focused gamified apps, the paper identifies technologies most ready for real-world use in resource-limited settings.

05/08/2025

Good Morning 🙏💐

📰 Published Today in The Indian Express – In Good Faith Column

“Heart’s True Home: Tagore’s Poetry, Adi Shankaracharya’s Teachings Connect Us All”

By Dr. Shambo Samrat Samajdar & Dr. Shashank R Joshi

What happens when Rabindranath Tagore’s poetic celebration of life meets Adi Shankaracharya’s luminous insight into oneness? In our new article, we explore how these two timeless voices—though centuries apart—guide us to the same truth: that within and around us flows an infinite stream of bliss and consciousness.

Their combined wisdom teaches us to find sacredness in daily life, recognize our shared essence, and dissolve the illusion of separateness—leading us back to our heart’s true home.

🙏

04/08/2025

🕉️ This Shravan Monday, let’s reflect on Shiva: From ‘I’ to ‘We’ – The Journey Beyond Self 🕉️

Our article in today’s TOI Speaking Tree explores how Shiva transforms ego into empathy, endings into new beginnings, and isolation into oneness. He is the stillness behind chaos, the dance within silence, and the divine spark that turns “I” into “We.” 🌌

🙏 Aum Namah Shivaya— may His grace lead us inward, where all true journeys begin.

(Authors: Dr. Shambo S Samajdar & Dr. Shashank R Joshi)

📰 Read in TOI Speaking Tree today!
Shiva: From ‘I’ to ‘We’ – The Journey Beyond Self

Daily Ecstasy News: Shiva, beyond deity, embodies the universe's rhythm, residing within us as witness and breath. He dissolves ego, transforming 'I' into 'We,' fostering

03/08/2025

🧬 Scientific Update | Consensus on OAD Classification Framework

📍Date: August 3, 2025

📌 Event: Expert Consensus Panel on Obstructive Airway Disease (OAD) Classification

🎯 Focus: Evaluating the Delphi results and proposing a pharmaco-response-based model (PRBC)

🔍 What Was Discussed
Leading pulmonologists, pharmacologists, and respiratory researchers convened to critically appraise existing asthma-COPD classifications and evaluate the need for a functionally and biologically grounded framework.

Key findings from the recent Delphi consensus survey were presented, revealing:

🔹 Low satisfaction with current diagnostic categories (mean ~5.5)
🔹 Strong endorsement for the PRBC model's feasibility, reproducibility, and clinical applicability (mean >7.0)
🔹 High support for integrating Glycopyrronium Responsiveness (GPR) and Th2 biomarkers to refine OAD endotyping and guide therapy

🔬 Why the Change Is Needed

Traditional guideline-based approaches often misclassify or inadequately guide therapy in overlapping or atypical OAD cases. The proposed Pharmaco-Response Based Classification (PRBC) offers a practical alternative:
✅ Categorizes patients based on objective bronchodilator response (Salbutamol, Glycopyrronium)
✅ Refines phenotype using FeNO, eosinophils, and IgE biomarkers
✅ Aligns diagnosis with pharmacologic precision and therapeutic relevance

🧠 Key Message

The group strongly supports PRBC as a next-generation classification system for OAD, with the potential to improve treatment individualization and close the gap between diagnosis and drug response.

👉 Stay tuned for publication of the consensus document and rollout of clinical toolkits to support implementation in both primary and specialist care.

🔗

31/07/2025

🙏 Sharing our new article in TOI Speaking Tree:
"The Wound That Led to the Stars: How Insult Became Dhruva’s Way to the Divine"

By Dr. Shashank R Joshi & Dr. Shambo S Samajdar

What if an insult isn’t a setback—but a sacred spark?

Young Dhruva turned rejection into radiant strength, pain into purpose. His story reminds us: don’t react—transform.

🪷 “The insult that started it all had been transformed. It was no longer a wound—it had become a window to eternity.”

🔗 Read here
https://timesofindia.indiatimes.com/speaking-tree/daily-ecstasy/the-wound-that-led-to-the-stars-how-insult-became-dhruvas-way-to-the-divine/articleshow/123016518.cms

Would love your thoughts! 🌟

Daily Ecstasy News: A young prince Dhruva, faced with a cruel insult from his stepmother, transforms his pain into spiritual strength. Instead of seeking revenge, he emba

24/07/2025

🌟 Privileged to Contribute at MERIDIAN 2025 – The Peak of Precision
📍 Hotel Vivanta, Kolkata EM Bypass
🗓️ Thursday, 24th July 2025

It was an absolute honor to be part of MERIDIAN 2025, a high-impact scientific forum that brought together some of the finest minds in diabetes care and clinical endocrinology.

🧠 I had the opportunity to speak on:
🔹 “Multipronged T2DM Management Strategy: Role of Once-Weekly GLP-1 RA”
Discussing the evolving positioning of Dulaglutide in the era of newer agents like semaglutide and tirzepatide, guided by latest CVOTs and real-world applicability.

With deep gratitude and respect, I acknowledge and thank the esteemed faculty who enriched the conclave with their presence and insights.

🎙️ Speakers
Dr. Sanjay K Shah – Case-based discussion on basal insulin applicability
Dr. S S Samajdar – Multipronged T2DM strategy
Dr. Sujoy Majumdar – Postprandial glucose control with ultra-rapid insulin

👨‍⚖️ Chairs of the Session
Dr. Anirban Majumder
Dr. Subhankar Chowdhury
Dr. Binayak Sinha

🧑‍⚕️ Eminent Panelists
Dr. Debasis Giri
Dr. H N Chakravarti
Dr. Amitabh Sur
Dr. Subir Ray
Dr. S Bhattacharyya
Dr. S Roychaudhuri

🙏 My sincere thanks to the entire MERIDIAN team and organizing committee for curating such a meaningful and academically rich platform.

Together, we continue to push the frontiers of precision diabetes care through collaboration, evidence, and patient-centered insight.

🔖

23/07/2025

Unseen. Yet Always Seen.

He clicked it when I wasn’t ready. I didn’t even know the lens was on me.

But isn’t that how life often works?

We move unaware, thinking no one’s watching — yet every action, every thought, every emotion is quietly recorded by the Supreme Observer. The Divine doesn’t wait for us to pose. It captures the real us — in our honesty, our flaws, our silences.

That unexpected photo reminded me: ignorance of being seen doesn’t mean we’re not seen. The cosmic camera never blinks.

Every moment is being documented — not for judgment, but for awakening.

23/07/2025

Becoming Zero – A Journey Into the Sacred Void

In today's Speaking Tree (TOI), we reflect on the profound spiritual and scientific symbolism of zero—not as a mere number, but as a gateway to truth. When you add zero to something, it changes nothing. When you multiply by zero, the ego dissolves. When you divide by zero, the mind collapses in paradox. Zero, or shunya, is not emptiness—it is the formless fullness from which everything emerges. In Indian philosophy, this is Shiva—the silence before sound, the stillness beneath motion. From mathematics to mysticism, from quantum physics to meditation, the wisdom of zero invites us to become nothing… and in doing so, become everything.