16/03/2026
NMN and NR are popular for boosting NAD+.
The science behind NAD+ support is real.
But dosage and context matter.
A 2024 study published in Nature Medicine highlighted that excess niacin metabolism can produce metabolites such as 4PY and 2PY, which were associated with vascular inflammation and elevated cardiovascular risk markers.
What does that mean?
It does not mean NAD+ precursors are inherently dangerous.
It means high-dose, unsupervised supplementation — especially in the 500–1000 mg range commonly marketed — may carry biochemical consequences that are rarely discussed.
More is not always better.
And longevity pathways require precision, not hype.
At iThrive Essentials, we believe supplementation should be:
✔️ Evidence-aware
✔️ Dose-conscious
✔️ Clinically contextual
✔️ Transparent about both benefits and risks
Because supporting cellular energy should never come at the expense of long-term safety.
Always evaluate dose, context, and supervision before starting high-potency NAD+ protocols.