01/12/2025
𝐖𝐡𝐞𝐧 𝐉𝐨𝐢𝐧𝐭 𝐏𝐚𝐢𝐧 𝐇𝐢𝐝𝐞𝐬 𝐚 𝐃𝐞𝐞𝐩𝐞𝐫 𝐒𝐞𝐜𝐫𝐞𝐭: 𝐀 𝐃𝐢𝐚𝐠𝐧𝐨𝐬𝐭𝐢𝐜 𝐏𝐮𝐳𝐳𝐥𝐞.
I want to share a story from my early days of practice that profoundly changed how I approach diagnostic puzzles.
I remember a patient, a middle-aged gentleman, who visited with debilitating pain across multiple joints—knees, ankles, and wrists were all swollen and tender. He was frustrated and in pain. all standard rheumatology panel: Rheumatoid Factor, Anti-CCP, ANA, CRP... you name it were available with him and was negative.
It didn't fit the typical pattern of Rheumatoid Arthritis or Lupus. We were hitting a diagnostic dead end, treating the symptoms without knowing the cause.
During one follow-up, while discussing his general health history again, he casually mentioned, "Oh, by the way, doctor, I’ve been seropositive for a few years now, managing it with ART."
That was the moment everything clicked.
The missing piece wasn't a rheumatological marker; it was an underlying viral infection. The diagnosis wasn't standard arthritis; it was likely HIV Arthropathy.
As the image above states: HIV May Mimic Arthritis!!
It’s a crucial clinical lesson that is often overlooked.
Startlingly, musculoskeletal symptoms can sometimes be the very first sign of an HIV infection, or they can appear in patients already managing the condition.
Here is what we need to know about HIV Arthropathy:
🔹 The Mimic: It can look exactly like Rheumatoid Arthritis (symmetrical joint pain), Psoriatic Arthritis, or Reactive Arthritis (often affecting lower limbs like knees and ankles).
🔹 The Cause: The inflammation isn't just an opportunistic infection; it can be caused by the virus itself directly affecting joint tissues, or by the body's chronic immune activation fighting the virus.
🔹 Pain Levels: The pain can range from mild aches (arthralgia) to severe, acute inflammation with swelling and fluid accumulation.
🔹 Whatever the Stage: It can occur at any stage of HIV infection, independent of the CD4 count.
That patient taught me that a complete history is the most powerful diagnostic tool we have. Today, on World AIDS Day, let’s remember that this virus affects more than just the immune system. It can mask itself in ways we don't expect.
Awareness leads to earlier diagnosis, better pain management, and improved quality of life.
Join the fight. Spread awareness. And let’s prevent HIV and not be shy about it !!