Yotsuba Japan Company

17/11/2025

15/11/2025

Menstrual pain is often attributed to hormones alone, but the underlying biology is more complex.
Each month, the endometrium enters a renewal phase. During this process, some epithelial cells become more mobile — a shift known as epithelial–mesenchymal transition (EMT).
When EMT becomes more active than expected, the tissue responds with stronger inflammation, which increases sensitivity and discomfort.

The gut also plays an important role.
Around 90% of the body’s serotonin is produced in the intestine, where it influences motility and pain perception.
A balanced microbiota supports this pathway and helps maintain a calmer physiological state during the cycle.
Some gut bacteria can also produce equol, a metabolite of soy isoflavones with mild estrogen-like and anti-inflammatory properties.
Certain strains of Lacticaseibacillus paracasei may enhance this process, supporting hormonal and tissue stability.

Postbiotics provide another mechanism that contributes to balance.
These are not live bacteria but inactivated microbial components that interact with immune receptors through molecular signals.
They do not colonize the gut, yet they help regulate inflammation, support mucosal immunity, and stabilize epithelial barriers.
Heat-killed Lacticaseibacillus paracasei is one of the most studied examples: it shows the ability to modulate IL-10/IL-12, increase secretory IgA, and — in in-vitro models — reduce activity in pathways linked to EMT.

This is the postbiotic used in the Sakulora® Cherry Blossom Probiotic Multi Complex, which provides 50 billion heat-killed L. paracasei derived from cherry blossoms.
According to the developer’s data, the complex supports IgA, serotonin pathways, collagen and hyaluronic acid expression, and shows dose-dependent effects on EMT-related signaling.
The formula also includes vitamin D₃, iron, iodine, zinc from yeast, and highly bioavailable calcium from scallop shells, forming a comprehensive base for maintaining balance throughout the cycle.

02/11/2025

Each component of the formula was selected for stability, safety, and synergy.
Together, they form a daily foundation for calm energy, clear skin, and internal balance.

Nutritional base

• Yeast-bound minerals (zinc, copper, iodine, selenium): highly bioavailable and gentle on digestion (+22% zinc absorption vs. standard forms).

• Calcium from scallop shells: a natural marine mineral that supports bones and muscles.

• Vitamin D₃: improves calcium absorption and immune defense.

• Iron, magnesium, and full B-complex: support metabolism, blood formation, and steady energy.

02/11/2025

Each component of the formula was selected for stability, safety, and synergy.
Together, they form a daily foundation for calm energy, clear skin, and internal balance.

Nutritional base

• Yeast-bound minerals (zinc, copper, iodine, selenium):
highly bioavailable and gentle on
digestion (+22% zinc absorption vs. standard forms).

• Calcium from scallop shells: a natural marine
mineral that supports bones and muscles.

• Vitamin D₃: improves calcium absorption
and immune defense.

• Iron, magnesium, and full B-complex:
support metabolism, blood formation, and steady energy.

02/11/2025

SAKULORA® —

Cherry Blossom Postbiotic Multi Complex

A new nutraceutical from Japan developed with Kansai University —
combining 17 essential vitamins and minerals with a cherry blossom–derived postbiotic (heat-killed Lacticaseibacillus paracasei Shidare — a beneficial bacterial strain originally found on cherry blossom petals).

What makes it special

Unlike probiotics (which are live bacteria), postbiotics are non-living bacterial components that still support the gut, immune system, and skin.
Because they’re heat-killed, they are completely safe and stable, but continue to deliver biological activity inside the body.

This postbiotic has been studied for its ability to:
• Strengthen the gut barrier
(helps prevent inflammation and irritation)
• Support serotonin production (the “happiness”
molecule made mostly in the gut)
• Improve skin hydration and elasticity by promoting
collagen and hyaluronic acid production
• Encourage hormonal balance through natural
equol formation (a compound that helps ease
PMS and menopause discomfort)
• Regulate EMT — epithelial–mesenchymal transition
(a natural process linked to tissue repair; if overactive,
it causes inflammation and discomfort)

Nutritional base

• Yeast-bound minerals (zinc, copper, iodine, selenium):
better absorbed and easier on digestion
(+22% zinc bioavailability vs. common forms)
• Calcium from scallop shells: a natural marine
source that supports bones and muscles
• Vitamin D3: helps calcium absorption and immune defense
• Iron, magnesium, and a full B-complex:
for metabolism, blood formation, and energy

27/10/2025

With age, the processes that keep cells alive begin to slow down.
Mitochondria — the parts of the cell that turn nutrients into energy — lose efficiency.
Energy production drops, oxidative stress rises, and recovery takes longer.
That’s one of the main reasons why metabolism changes over time.
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NMN (nicotinamide mononucleotide) helps the body make NAD⁺, a coenzyme that supports mitochondrial function, DNA repair, and cell stability.
When NAD⁺ levels are low, mitochondria can’t produce enough energy, repair slows, and damaged molecules start to accumulate.
By helping restore NAD⁺, NMN supports the natural systems that keep cells working as they should.
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This process activates sirtuins — proteins that regulate how mitochondria use energy, control inflammation, and help the cell stay clear of damaged material.
It’s not a “rejuvenation” effect, but part of the body’s normal renewal mechanism.
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There’s also an indirect link to telomeres — the protective ends of chromosomes that shorten under stress and oxidative damage.
When NAD⁺ is maintained, telomeres remain more stable, and cells preserve their ability to divide and renew for longer.
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Since 2020, NMN has been officially recognized in Japan as a food-grade ingredient, not a drug.
It’s designed to support the body’s natural balance — to help the system work as it was meant to, even as years go by.
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16/10/2025

Japanese nutraceutical science has been steadily shifting toward mineral complexes that restore physiological balance at multiple levels.
Among the most studied are water-soluble silica and deep-sea minerals — two natural systems shown to influence metabolism, skin structure, and gut equilibrium.

Why this matters:

• Deep-sea minerals — measurable improvements in metabolism, insulin sensitivity, and gut health.
• Bioavailable silica — clinically demonstrated support for skin and connective-tissue resilience.

It reflects a quiet but important shift in Japan’s 2025 nutraceutical landscape — from single nutrients to multi-mineral systems designed to sustain equilibrium across metabolism, structure, and the microbiome.

27/09/2025

Our bodies are built on balance — a delicate harmony of molecules that keep us moving, looking, and feeling our best.
One of these molecules is NAG (N-Acetylglucosamine).

It may sound technical, but it is in fact a natural sugar molecule that already exists in our own tissues. It plays a quiet but essential role: it is the direct building block for hyaluronic acid — the compound that cushions our joints and keeps our skin hydrated and resilient.

With age, natural levels of NAG decline. That’s why joints may feel stiffer, skin may lose elasticity, and recovery may take longer. Replenishing NAG means giving your body back a part of what it naturally knows and needs.

The benefits of NAG:

✔️ Helps maintain smooth and comfortable joint movement
✔️ Supports cartilage strength and resilience
✔️ Promotes skin hydration and elasticity for a healthier appearance
✔️ Contributes to overall comfort and vitality from within

25/09/2025

Most people know vitamin C as a daily essential, but fewer realize how much depends on the way it’s delivered. Traditional liposomal products usually come in liquid form.
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Liquid liposomes can work, but in water they are unstable, prone to clumping, and may lose effectiveness over time. They are also harder to store and less convenient to use in capsules or powders.
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This is where Zeal Technology™ changes the story. 🧑‍🔬
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It is the first liposomal system developed in a stable powder form. Imagine tiny protective spheres built from natural phospholipids, but instead of floating in liquid, they are held in a solid, crystal-like structure. This keeps them uniform in size, resistant to breakdown, and able to survive storage without losing strength.
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For vitamin C, that means more than just numbers in a study. It means:
– The vitamin reaches your bloodstream in higher amounts and stays there longer.
– It is released gradually, giving your immune cells and tissues steady support instead of a quick peak and drop.
– It is easier on the stomach than traditional acidic tablets.
– And because it’s in a dry, stable form, it’s far simpler to handle and keep fresh.
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In short, Zeal Technology™ takes the well-known benefits of liposomal delivery and makes them stronger, more reliable, and more practical for everyday use. With this innovation, vitamin C is not just better absorbed — it works in harmony with the body, right where and when it is needed.

20/09/2025

Proper nutrition and vitamins will help support immunity in the fall.
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Vitamins play a significant role in maintaining health, especially in the fall, as it’s prudent to focus on supporting and boosting immunity.
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Just because we ate a lot of fruits and vegetables in the summer does not mean we have stocked up on vitamins for the coming winter.
It’s best to eat seasonally, so to replenish vitamin supplies in the fall, autumnal products suited to your living climate are ideal. It’s best to consume vitamins in their natural form, as fruits and vegetables.
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Ascorbic acid, also known as vitamin C, should be consumed daily, as it isn’t synthesized in the body. Vitamin C is a powerful antioxidant, plays a crucial role in metabolism, in oxidation-reduction reactions, and boosts immunity.
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However, it’s important to note that ascorbic acid breaks down at high temperatures. Seasonal sources of vitamin C include bell peppers, cabbage, rowanberries, rose hips, lemons, oranges, and apples.
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Vitamin D. It is involved in mineral metabolism, is responsible for calcium deposition in bones, and prevents the onset of osteoporosis. The need for this vitamin is fully met by ultraviolet radiation. In the fall, when there isn’t enough sunlight, additional sources of vitamin D are egg yolks and fish.
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Especially halibut, cod, herring, mackerel, and salmon. Dairy products with high vitamin D content are cheese, cottage cheese, and butter.
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Eat correctly, maintain a balanced diet, consume more vitamins, and stay healthy!

13/09/2025

Vitamin C is central to human biology: it fuels antioxidant defense, collagen production, and immune cell activity. But there is a practical problem.
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Standard vitamin C has a ceiling.
The body can only absorb a certain amount through the intestine at once. Beyond that, absorption plateaus and the excess is quickly excreted. As a result, even large oral doses create only brief spikes in blood levels, which drop within hours.
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Why does this matter?
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Immune cells such as leukocytes actively concentrate vitamin C. They require a steady supply to function under stress — whether that stress comes from infection, inflammation, or environmental exposure. Short plasma spikes are often not enough to sustain those cellular stores.
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Liposomal vitamin C alters this pattern.
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Encapsulated in microscopic lipid vesicles, it avoids degradation in the gut, enters circulation more efficiently, and is taken up by immune cells in higher amounts. Clinical studies show measurable differences: greater peak levels in blood, longer retention over 24 hours, and higher concentrations inside white blood cells compared with standard vitamin C.
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It’s not about taking more vitamin C. It’s about keeping it where the body needs it, for longer, with less digestive discomfort. This makes liposomal delivery particularly relevant when demands are high — recovery, immune challenge, or chronic stress.