30/09/2024
Emphysematous Pyelonephritis
Author Information and Affiliations
Last Update: January 11, 2024.
Go to:
Introduction
Emphysematous pyelonephritis (EPN) is a severe necrotizing infection that affects the upper urinary tract, involving the renal parenchyma and, in some instances, the perirenal tissues of the kidney. This condition frequently leads to gas formation in the renal parenchyma, collecting system, or perinephric tissue. Emphysematous pyelitis (gas in the renal pelvis) or emphysematous cystitis (gas within the bladder wall and lumen) may occur independently of associated EPN.
Diabetes mellitus represents the most prevalent risk factor, found in over 90% of patients diagnosed with EPN.EPN is a life-threatening disease, with reported mortality rates ranging from 40% to 90%.Clinical diagnosis of the condition closely mirrors acute pyelonephritis, which requires accurate evaluation through imaging, particularly computed tomography (CT) scans. Treatment options for EPN have evolved, with aggressive surgical intervention and more conservative therapeutic approaches, primarily involving percutaneous drainage and antimicrobials.
Go to:
Etiology
Escherichia coli and Klebsiella pneumoniae are the most common pathogens associated with EPN, accounting for 49% to 67% and 20% to 24% of cases, respectively. Other reported organisms include Proteus, Enterococcus, Clostridium, Aspergillus, and, rarely, Candida spp. In some instances, infections exhibit polymicrobial characteristics.
Go to:
Pathophysiology
Uncontrolled diabetes can cause bacterial propagation and disease progression due to high tissue glucose levels, impaired oxygen supply to the kidneys, and microvascular disease.Gas accumulation observed in EPN is likely a consequence of microbial fermentation of glucose and lactate, producing gases such as carbon dioxide, hydrogen, and nitrogen.Urinary tract obstructions can reduce renal blood flow and tissue perfusion, exacerbating the infection.