08/12/2023
⁉ HOW DOES HP RESISTANCE IN Stomach?
Helicobacter pylori is almost the only type of pathogenic bacteria that can infect and survive in the extremely harsh environment of the stomach. While most other bacteria are destroyed in the stomach, Helicobacter pylori has very sophisticated mechanisms that enable it to invade and bypass the immune system to survive for a long time in the body. Therefore, eradication as well as prevention of Hp infection also becomes much more difficult.
💢 The process of infection and pathogenicity of H.p. bacteria consists of 4 main steps, including the extremely important role of a surface protein on bacteria - urease.
1⃣ Helicobacter pylori enters the stomach, secretes urease, creates a neutral environment around it to protect bacteria from the effects of gastric acid.
2⃣ The enzyme urease reacts with the ingredients in the gastric mucosa, reducing the adhesion to help bacteria pass through the natural protective layer to reach the gastric mucosa.
3⃣ Firmly adheres to gastric mucosa through binding between bacterial adhesins and receptors on the surface of gastric mucosal cells. Here bacteria can also pe*****te inside the cells of the stomach lining and multiply.
4⃣ Secretion of toxins that cause inflammation, ulcers, and even stomach cancer.
In the process of infection, Helicobacter pylori has unique mechanisms to help it escape from the body's immune system: frying helps the bacteria move quickly to avoid the pursuit of granulocytes, copper. When urease is secreted, macrophages lose their ability to "eat" bacteria.
💊 It can be seen that the enzyme Urease is the decisive factor in the ability of H. pylori to infect the gastric mucosa. On the studies, it was found that when Hp bacteria were mutated with urease, they lost the ability to infect the stomach, while strains of Hp still had urease enzyme, the ability to infect was 100%. Therefore, Japanese scientists have researched and created an antibody capable of specifically inhibiting the urease enzyme of Hp bacteria called OvalgenHP with the goal of controlling the growth and spread of the virus. Helicobacter pylori in the community. OvalgenHP is highly appreciated in the combination to increase the effectiveness of Hp treatment, prevent infection and re-infection, and is safe for both newborns and pregnant women.
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