Lebanese Porphyria Support Association-LPSA

18/12/2025

11/12/2025

10/12/2025

Here are the main kinds (types) of porphyria, grouped by how they affect the body:

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🌞 1. Cutaneous Porphyrias (Affect the Skin)

These types mainly cause skin sensitivity to sunlight, blistering, and scarring.

1. CEP – Congenital Erythropoietic Porphyria
Very rare, starts in infancy. Caused by UROS enzyme deficiency.

2. PCT – Porphyria Cutanea Tarda
Most common type; usually appears in adults.

3. HEP – Hepatoerythropoietic Porphyria
Severe, childhood form related to PCT.

4. EPP – Erythropoietic Protoporphyria
Painful burning reaction to sunlight without blisters.

5. XLP / XLEPP – X-Linked Protoporphyria
Similar to EPP but inherited differently.

6. VP – Variegate Porphyria
Can cause both skin and neurological symptoms.

7. HCP – Hereditary Coproporphyria
May also have skin symptoms in some cases.

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⚡ 2. Acute Porphyrias (Affect the Nervous System)

These types cause acute attacks with stomach pain, nausea, weakness, and nerve issues.

1. AIP – Acute Intermittent Porphyria

2. HCP – Hereditary Coproporphyria (can be acute and cutaneous)

3. VP – Variegate Porphyria (can be acute and cutaneous)

4. ADP – ALA-Dehydratase Deficiency Porphyria (extremely rare).
🌞 أولاً: البورفيريات الجلدية (تؤثر على الجلد)

تُسبب حساسية شديدة للشمس، احمرار، فقاعات، وأحياناً تغيّرات في لون الجلد.

1. CEP – البورفيريا الحمراء الولادية (الخلقية)
نوع نادر جداً يظهر من الطفولة، بسبب نقص إنزيم UROS.

2. PCT – البورفيريا الجلدية المتأخرة
الأكثر شيوعاً، تظهر عادة عند البالغين.

3. HEP – البورفيريا الكبدية الدموية الطفولية
شكل شديد يشبه PCT لكنه يظهر عند الأطفال.

4. EPP – البورفيريا البروتوبورفيرية
تسبب ألم شديد عند التعرض للشمس بدون فقاعات.

5. XLP / XLEPP – البورفيريا البروتوبورفيرية المرتبطة بالكروموسوم X
شبيهة بـEPP لكن لها نمط وراثي مختلف.

6. VP – البورفيريا المتنوعة (فارياجيت)
قد تُسبب أعراض جلدية وعصبية معاً.

7. HCP – البورفيريا الكوبروبورفيرية الوراثية
قد تكون جلدية أو عصبية.

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⚡ ثانياً: البورفيريات الحادة (تؤثر على الجهاز العصبي)

تُسبب نوبات حادة مثل ألم شديد بالبطن، قيء، ضعف عضلي، واضطرابات عصبية.

1. AIP – البورفيريا المتقطعة الحادة

2. HCP – الكوبروبورفيريا الوراثية (جلدية/عصبية)

3. VP – البورفيريا المتنوعة (جلدية/عصبية)

4. ADP – بورفيريا نقص إنزيم ALA-dehydratase (نادرة جداً)

10/12/2025

Porphyria is a group of rare genetic disorders caused by problems in the body’s ability to make heme—a vital component of hemoglobin. When one of the enzymes in the heme-production pathway doesn’t work properly, certain chemicals called porphyrins or their precursors build up in the body.

This buildup can cause a range of symptoms depending on the type of porphyria, such as:

Skin sensitivity to sunlight (blistering, redness, pain)

Neurological symptoms (abdominal pain, muscle weakness, nerve problems)

Changes in urine color (sometimes reddish or dark)

Porphyrias are usually inherited and vary from very mild to severe. Different types affect either the skin, the nervous system, or both.

05/12/2025

04/12/2025

https://icpp2026.org

30/11/2025

Porphyria Fact

How does one get porphyria?

Most porphyrias are inherited. However, one type, Porphyria Cutanea Tarda (PCT), may either be inherited (also referred to as “familial”) or “sporadic” due to various environmental factors. In each type of there is a deficiency of a specific enzyme. These enzymes are involved in the synthesis of heme, a substance important to many body functions which is found in large amounts in bone marrow and red blood cells (which contain # hemoglobin), and which also has important functions in the liver, muscles, and other tissues. The type of porphyria present is determined by which enzyme is deficient; these enzyme deficiencies are usually inherited. Environmental factors, such as drugs, diet, and sun exposure can, depending on the type of porphyria, greatly influence the severity of symptoms.

29/11/2025

Lebanese Porphyria Support Association-LPSA
United Porphyrias Association