23/11/2025
Prepregnancy metformin use associated with lower risk of severe nausea and vomiting of pregnancy and hyperemesis gravidarum - Model and potential prevention strategy
A, When GDF15 levels are low before pregnancy because of genetics and other factors, then the patient may be hypersensitive to the rise in GDF15 during pregnancy and at increased risk for severe nausea and vomiting and hyperemesis gravidarum. B, When GDF15 levels are high before pregnancy because of prepregnancy metformin treatment and other factors, then the patient may be desensitized to the rise in GDF15 during pregnancy and at low risk for severe nausea and vomiting and hyperemesis gravidarum. https://ow.ly/V22u50XwvRX
