PGTA Singapore

12/07/2022

Why Assessing Genetic Normality Of IVF Embryos By AI Is A Better Option https://codeblue.galencentre.org/2022/07/08/why-assessing-genetic-normality-of-ivf-embryos-by-ai-is-a-better-option-dr-alexis-heng-boon-chin/

19/11/2021

Cost-effectiveness of doing genetic testing of IVF embryos ( PGS / PGT-A ) to prevent Down syndrome and other genetic abnormalities in older mothers

Currently, there is an increasing trend of late motherhood in Singapore and many other countries throughout the world, as rising numbers of better-educated women choose to postpone marriage and childbearing in pursuit of career development. Nevertheless, there are heightened risks of conceiving a ba...

14/10/2021

Genetic Testing Of IVF Embryos Overseas: What Singaporean Patients Should Know

Singaporean patients traveling abroad for IVF treatment should be cautious not to be ‘pushed’ into undertaking PGS unnecessarily. The post Genetic Testing Of IVF Embryos Overseas: What Singaporean Patients Should Know appeared first on theAsianparent - Your Guide to Pregnancy, Baby & Raising Kid...

14/10/2021

IVF genetic testing to prevent birth defects in older women https://www.biospectrumasia.com/opinion/54/19177/ivf-genetic-testing-to-prevent-birth-defects-in-older-women.html?fbclid=IwAR13Ka9CszB9YHWFMZMav-W_EJJcTpoY-CrwTTDcmBy7upyNmpbsBRvXBKU

In conversation with Dr. Alexis Heng Boon Chin, Associate Professor, Peking University, China

10/03/2021

High attrition rate of 72% for PGS / PGT-A pilot trial in Singapore - as announced by Ministry of Health (MOH) - Why?

https://singaporemotherhood.com/forum/threads/pgs-pgt-a-in-singapore-high-attrition-rate-of-72-reported-by-ministry-of-health-moh-why.263844/

The Ministry of Health in Singapore has reported that the pilot trial of PGS / PGT-A in Singapore suffers from a high attrition rate of 72%. The question is Why? Please see: https://www.channelnewsasia.com/news/singapore/rahayu-mahzam-on-pre-implantation-genetic-screening-14313308 MP Rahayu...

21/02/2021

Abnormal embryos diagnosed by PGS / PGT-A can give rise to normal healthy births. PGS maybe unnecessary and a waste of money!

Please take note of the controversy surrounding PGS with regards to Mosaic embryos, which have a mixture of normal (euploid) and abnormal (aneuploid) cells. These are often tested to be genetically abnormal by PGS, but in fact can give rise to normal healthy births.
As seen in the attached diagram of a blastocyst-stage human embryo, the ICM gives rise to the embryo, while the TE gives rise to the placenta and yolk sac. Testing a few cells from the TE only gives you a probability about what's going on in the ICM. An embryo with abnormal (aneuploid) TE but normal ICM most likely will still make a healthy baby.
Hence, by discarding such mosaic embryos that are tested abnormal during PGS, one would lower the cumulative chances of IVF success.

21/02/2021

PGS (PGT-A) is prone to misdiagnosis due to mosaic embryos. Discarding of mosaic embryos that are tested to be abnormal by PGS (PGT-A), but which could otherwise give rise to normal healthy births, lowers the chances of IVF success.

21/02/2021

New scientific evidence dispute the beneficial effects of PGS / PGT-A in IVF
Treatment

Many fertility clinic websites claim that PGS can improve IVF success for older women and patients with multiple IVF failures or recurrent miscarriages. However, there has recently been increasing contradictory information from different sources, which dispute the beneficial claims of PGS in IVF...

21/02/2021

Is PGS (PGT-A) useful for older women at risk of Down Syndrome, or patients with low ovarian reserves?

Relevant Q & A on the Quora website: https://www.quora.com/Why-may-it-be-unnecessary-for-older-women-undergoing-IVF-or-ICSI-to-do-pre-implantation-genetic-screening-PGS-PGT-A/answer/Alexis-Heng https://www.quora.com/How-can-I-do-preimplantation-genetic-screening-PGS-or-PGT-A-in-Singapore-1...

21/02/2021

Video podcasts that explain the Preimplantation Genetic Screening (PGS or PGT-A) procedure. What are the limitations and risks of PGS / PGT-A?

Here are some excellent video podcasts that introduce and explain the Preimplantation Genetic Screening (PGS or PGT-A) procedure to patients:

21/02/2021

What Singaporean patients should know before doing PGS (embryo genetic testing) when going for IVF overseas

There are plenty of arguments against doing preimplantation genetic screening - PGS / PGT-A, and it’s up to you to decide if they outweigh the pros… https://theduff.co.uk/pgs-testing-ivf/ Argument 1 against PGS: it’s expensive Paying an extra $5,000 (ish) per cycle – on top of the $10,000 or...

21/02/2021

Here are the latest news on Preimplantation Genetic Screening (PGS / PGT-A), which cast doubts on the usefulness and effectiveness of this technique for older women undergoing IVF / ICSI :

Here are the latest news on Preimplantation Genetic Screening (PGS / PGT-A), which cast doubts on the usefulness and effectiveness of this technique for older women undergoing IVF / ICSI : Prominent Physicians and Scientists Criticize Continued Utilization of Preimplantation Genetic Testing for...