Wellness Concierge in the Sky

25/09/2024

Kidney disease affects approximately 37 million American adults. It occurs when your kidneys become damaged and cannot perform their function. Damage may be caused by diabetes, high blood pressure, and various other long-term (chronic) conditions. https://www.healthline.com/health/kidney-disease

22/09/2024

Which of these exercises are you doing regularly?

Regular physical activity is important at any age, but especially for older adults. Physical activity keeps muscles, joints, and bones healthy; reduces your disease risk; helps reduce your risk of falls and fractures; and more.

For our guide to staying active in older adulthood, head to this link: https://bit.ly/4dahrq3

20/09/2024

𝗚𝗲𝗻𝗲𝘁𝗶𝗰 𝗙𝗮𝗰𝘁𝗼𝗿𝘀 𝗶𝗻 𝗔𝗹𝗹𝗲𝗿𝗴𝗶𝗲𝘀 𝗮𝗻𝗱 𝗞𝗶𝗱𝗻𝗲𝘆 𝗗𝗶𝘀𝗼𝗿𝗱𝗲𝗿𝘀

Genetic factors play a significant role in the development and progression of both allergies and kidney disorders. Understanding these genetic influences can help in diagnosing, managing, and potentially preventing these conditions. This guide covers how genetics contributes to both allergies and kidney diseases, and the interrelation between the two.

𝗚𝗲𝗻𝗲𝘁𝗶𝗰 𝗮𝗻𝗱 𝗔𝗹𝗹𝗲𝗿𝗴𝗶𝗲𝘀
- Hereditary Influence: Allergies, such as asthma, hay fever, and eczema, often run in families. Specific genes are linked to immune system responses, influencing the body's reaction to allergens.
- Gene-Environment Interaction: While genetics set the stage, environmental factors (like exposure to allergens or pollutants) can trigger or worsen allergic reactions.
- Key Genes Involved:
- IL4, IL13: These genes are associated with the production of Immunoglobulin E (IgE), a key player in allergic responses.
- HLA Genes: These influence how the immune system distinguishes between self and non-self, affecting susceptibility to allergies.

𝗚𝗲𝗻𝗲𝘁𝗶𝗰𝘀 𝗮𝗻𝗱 𝗞𝗶𝗱𝗻𝗲𝘆 𝗗𝗶𝘀𝗼𝗿𝗱𝗲𝗿𝘀
- Hereditary Kidney Diseases: Conditions such as polycystic kidney disease (PKD) and Alport syndrome are directly caused by genetic mutations.
- Genetic Predisposition to Kidney Damage: Certain genetic variations can increase the risk of developing chronic kidney disease (CKD), especially when combined with lifestyle factors like high blood pressure or diabetes.
- Key Genes Involved:
- PKD1, PKD2: Mutations in these genes cause polycystic kidney disease.
- COL4A3, COL4A4, COL4A5: Mutations here are linked to Alport syndrome, a genetic condition affecting the kidneys' filtering units.

𝗧𝗵𝗲 𝗜𝗻𝘁𝗲𝗿𝗿𝗲𝗹𝗮𝘁𝗶𝗼𝗻 𝗕𝗲𝘁𝘄𝗲𝗲𝗻 𝗔𝗹𝗹𝗲𝗿𝗴𝗶𝗲𝘀 𝗮𝗻𝗱 𝗞𝗶𝗱𝗻𝗲𝘆 𝗗𝗶𝘀𝗼𝗿𝗱𝗲𝗿𝘀
- Shared Genetic Pathways: Some genetic pathways influencing immune responses are involved in both allergies and certain kidney disorders. For example, inflammation-related genes can contribute to both allergic reactions and kidney inflammation.
- Immune System Dysfunction: Genetic predispositions to immune system dysfunction can lead to both heightened allergic responses and autoimmune kidney diseases, such as lupus nephritis.
- Comorbid Conditions: Patients with autoimmune diseases, which are influenced by genetic factors, may have both allergic conditions and kidney involvement, indicating a genetic link.

𝗧𝗿𝗲𝗮𝘁𝗺𝗲𝗻𝘁 𝗜𝗺𝗽𝗮𝗰𝘁𝘀
- Genetic Testing: Testing can identify individuals at risk for hereditary kidney diseases or those with a predisposition to severe allergies, allowing for early intervention.
- Family History: A thorough family medical history is crucial for identifying at-risk individuals and understanding the hereditary nature of these conditions.
- Gene Therapy: Research into gene therapy offers hope for treating genetic conditions like PKD and reducing the severity of some allergies.
- Biomarker: Identifying genetic biomarkers can improve early diagnosis and treatment options, reducing the burden of these chronic conditions.

The genetic factors influencing allergies and kidney disorders highlight the importance of a comprehensive approach to diagnosis and treatment. By considering genetic predispositions, healthcare providers can offer more personalized and effective care, improving outcomes for individuals with these complex conditions.

10/09/2024

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𝗬𝗼𝘂𝗿 𝗵𝗲𝗮𝗹𝘁𝗵 𝗶𝘀 𝗼𝘂𝗿 𝗽𝗿𝗶𝗼𝗿𝗶𝘁𝘆. 𝗟𝗲𝘁 𝘂𝘀 𝗯𝗲 𝘆𝗼𝘂𝗿 𝗽𝗮𝗿𝘁𝗻𝗲𝗿 𝗶𝗻 𝗵𝗲𝗮𝗹𝘁𝗵! 💪✨

07/09/2024

Kickboxing🥊 is a full-body workout that can transform your fitness. It helps build strength, burn calories, increase flexibility, and improve coordination. Mentally, it reduces stress, boosts confidence, and sharpens focus.

Whether you want to get fit, relieve stress, or challenge yourself, kickboxing offers something for everyone 😉

05/09/2024

𝗚𝗲𝗻𝗲𝘁𝗶𝗰𝘀 𝗮𝗻𝗱 𝘁𝗵𝗲 𝗗𝗶𝗴𝗲𝘀𝘁𝗶𝘃𝗲 𝗦𝘆𝘀𝘁𝗲𝗺: 𝗛𝗼𝘄 𝗢𝘂𝗿 𝗚𝗲𝗻𝗲𝘀 𝗜𝗻𝗳𝗹𝘂𝗲𝗻𝗰𝗲 𝗗𝗶𝗴𝗲𝘀𝘁𝗶𝗼𝗻

𝗢𝘃𝗲𝗿𝘃𝗶𝗲𝘄 𝗼𝗳 𝗗𝗶𝗴𝗲𝘀𝘁𝗶𝗼𝗻 𝗮𝗻𝗱 𝗚𝗲𝗻𝗲𝘁𝗶𝗰 𝗜𝗻𝗳𝗹𝘂𝗲𝗻𝗰𝗲
The digestive system breaks down food, absorbs nutrients, and removes waste. Genes regulate this process by controlling enzymes like lactase and amylase. Variations in these genes affect how well we digest different foods.

𝗚𝗲𝗻𝗲𝘁𝗶𝗰 𝗖𝗼𝗻𝘁𝗿𝗼𝗹 𝗼𝗳 𝗗𝗶𝗴𝗲𝘀𝘁𝗶𝘃𝗲 𝗘𝗻𝘇𝘆𝗺𝗲𝘀
The 𝗟𝗖𝗧 gene produces lactase for lactose digestion; variations can cause lactose intolerance. The 𝗔𝗠𝗬𝟭 gene produces amylase for breaking down carbohydrates; genetic differences affect carbohydrate digestion.

𝗚𝗲𝗻𝗲𝘁𝗶𝗰 𝗗𝗶𝘀𝗼𝗿𝗱𝗲𝗿𝘀 𝗔𝗳𝗳𝗲𝗰𝘁𝗶𝗻𝗴 𝗗𝗶𝗴𝗲𝘀𝘁𝗶𝗼𝗻
- 𝗖𝗲𝗹𝗶𝗮𝗰 𝗗𝗶𝘀𝗲𝗮𝘀𝗲: Mutations in 𝗛𝗟𝗔-𝗗𝗤𝟮 and 𝗛𝗟𝗔-𝗗𝗤𝟴 damage the small intestine due to gluten.
- 𝗟𝗮𝗰𝘁𝗼𝘀𝗲 𝗜𝗻𝘁𝗼𝗹𝗲𝗿𝗮𝗻𝗰𝗲: Variations in the 𝗟𝗖𝗧 gene reduce lactase production.
- 𝗖𝘆𝘀𝘁𝗶𝗰 𝗙𝗶𝗯𝗿𝗼𝘀𝗶𝘀: Mutations in 𝗖𝗙𝗧𝗥 lead to thick mucus that blocks pancreatic enzyme release.

𝗜𝗻𝗳𝗹𝘂𝗲𝗻𝗰𝗲 𝗼𝗳 𝗚𝗲𝗻𝗲𝘁𝗶𝗰𝘀 𝗼𝗻 𝘁𝗵𝗲 𝗚𝘂𝘁 𝗠𝗶𝗰𝗿𝗼𝗯𝗶𝗼𝗺𝗲
Genetics shape the gut microbiome, affecting bacteria types and amounts. This influences digestion, nutrient absorption, and overall health by affecting immune function and disease risk.

𝗣𝗲𝗿𝘀𝗼𝗻𝗮𝗹𝗶𝘇𝗲𝗱 𝗡𝘂𝘁𝗿𝗶𝘁𝗶𝗼𝗻 𝗮𝗻𝗱 𝗧𝗿𝗲𝗮𝘁𝗺𝗲𝗻𝘁
Genetic testing helps create personalized dietary plans based on genetic predispositions. Advances in genetic research lead to tailored treatments, improving digestive health through customized diets and therapies.

𝗖𝘂𝗿𝗿𝗲𝗻𝘁 𝗥𝗲𝘀𝗲𝗮𝗿𝗰𝗵
Studies identify genetic markers for digestive diseases, offering insights into conditions like IBD and IBS.

Genetics significantly affects digestion and digestive health. Understanding genetic factors is crucial for personalized dietary and treatment strategies, offering tailored solutions for improved digestive health and well-being.

04/09/2024

01/09/2024

SELANGOR LIFE SCIENCES CONVENTION SYNERGY CONFERENCE (SLiSS) 2024

Date: 17 & 18 October 2024 (Thursday & Friday)
Place: Exhibition Hall 6C, Level 1, KLCC

The focus this year is on:

PRECISION HEALTH on Day 1: This field of medicine tailors individual treatment plans to a person's specific genes, environment, and lifestyle.

GENERATIVE AI & HEALTHCARE on Day 2: AI and its potential to transform healthcare. This involves using artificial intelligence to develop new drugs, diagnostics, treatments and patient communication.

Speakers and Topics:

• Prof. Dr. Roberto Grobman, Chairman, Chief Scientist & Orthogeneticist, USA – Cell Metabolism: Overview of metabolic pathways, energy flow in a cell, and anabolism and catabolism.

• Dr. J.S. Rajkumar, Surgical Gastroenterologist, Founder & Chairman of Lifeline Hospitals, India - Defining Tomorrow’s Medicine. Personalization in medicine—driven by data-powered insights.

• Dr. Le Lu, Head of Alibaba DAMO Academy’s Global Medical AI R&D Team - Tech to the Future. Dedicating pioneering cutting-edge scientific and technological research to shape the future to diagnose, and create personalized treatment plans.

• Dr. Madan Mohan, Senior Interventional Cardiologist, MGM Healthcare, Chennai, India - The Future of Healthcare: Molecular Basis of Health and Disease. How genetic testing saves lives in heart.

• Ms. Shivani Narasimhan, Research Scientist (Genomics and Bioinformatics), Precisya Southeast Asia Pvt Ltd. - The Future of Healthcare: Molecular Basis of Health and Disease. Epigenetic and the molecular changes for the onset and progression of diseases.

• Novartis - The Promise of Pharmacogenetics. Personalized Prescription— In prescribing, genetic information, in combination with other factors, offers much better-targeted results.

• Radhakrishnan S, Executive Director Transceptar - The tremendous growth opportunities in Precision Health.

• Prof. Dr. Chong Pei Pei, Professor at the Faculty of Health & Medical Sciences, Taylor’s University - AI in Healthcare Today and Beyond.

And many more Speakers and Topics that is transforming healthcare of tomorrow.
Registration is OPEN. Visit – https://infomedconference.com/

This conference is HRDF Claimable.
To Claim from HRDF (if your organization contributes to HRDF)
Please contact WhatsApp at +6012-6369 438 or email us at bart.eduguidemsia@gmail.com.

01/09/2024

𝗡𝘂𝘁𝗿𝗶𝘁𝗶𝗼𝗻 𝗳𝗼𝗿 𝗖𝗵𝗶𝗹𝗱𝗿𝗲𝗻: 𝗧𝗮𝗶𝗹𝗼𝗿𝗶𝗻𝗴 𝗗𝗶𝗲𝘁 𝘁𝗼 𝗚𝗲𝗻𝗲𝘁𝗶𝗰 𝗣𝗿𝗼𝗳𝗶𝗹𝗲

How children's genetics can influence their nutritional needs by tailoring diets based on genetic profiles, parents and health care providers can optimize children's growth, development and overall health. It consists of:

𝗚𝗲𝗻𝗲𝘁𝗶𝗰 𝘃𝗮𝗿𝗶𝗮𝗯𝗶𝗹𝗶𝘁𝘆:
- Children have different genetic variations that affect how they metabolize nutrients, absorb vitamins and minerals, and react to certain foods. For example, some children may have a genetic predisposition to lactose intolerance, gluten sensitivity, or certain nutrient deficiencies.

𝗣𝗲𝗿𝘀𝗼𝗻𝗮𝗹 𝗡𝘂𝘁𝗿𝗶𝘁𝗶𝗼𝗻:
- Using genetic testing, it is possible to identify these unique needs and create a diet plan that ensures the child receives the nutrients they need. This approach can prevent potential health problems and support optimal development.

𝗕𝗲𝗻𝗲𝗳𝗶𝘁𝘀:
- Personalized nutrition based on genetics can improve energy levels, immune function, cognitive development, and prevent chronic conditions that may arise from improper nutrition.

𝗜𝗺𝗽𝗹𝗲𝗺𝗲𝗻𝘁𝗮𝘁𝗶𝗼𝗻:
- Parents and caregivers should work with health care providers to integrate genetic insights into children's diets. This may involve choosing foods rich in certain nutrients, avoiding potential allergens, and using supplements if necessary.

𝗙𝘂𝘁𝘂𝗿𝗲 𝗜𝗺𝗽𝗹𝗶𝗰𝗮𝘁𝗶𝗼𝗻𝘀:
- As genetic research advances, the ability to personalize nutrition will continue to improve, potentially leading to better health outcomes and a deeper understanding of the relationship between diet and genetics.

This approach emphasizes the importance of considering a child's genetic background when planning their diet, aiming for a more accurate and effective way to support their health and well-being.

22/08/2024

𝗧𝗵𝗮𝗹𝗮𝘀𝘀𝗲𝗺𝗶𝗮: 𝗚𝗲𝗻𝗲𝘁𝗶𝗰 𝗖𝗮𝘂𝘀𝗲 𝗮𝗻𝗱 𝗜𝗺𝗽𝗮𝗰𝘁𝘀

1.𝗚𝗲𝗻𝗲𝘁𝗶𝗰 𝗖𝗮𝘂𝘀𝗲
Thalassemia is a genetic blood🩸 disorder caused by mutations🧬 in the genes responsible for producing hemoglobin, the protein in red blood cells that carries oxygen.

𝗚𝗲𝗻𝗲𝘁𝗶𝗰 𝗠𝘂𝘁𝗮𝘁𝗶𝗼𝗻𝘀
-𝗜𝗻𝗵𝗲𝗿𝗶𝘁𝗮𝗻𝗰𝗲 𝗣𝗮𝘁𝘁𝗲𝗿𝗻: Both forms are inherited in an autosomal recessive manner. This means a person must inherit two copies of the mutated gene (one from each parent) to exhibit symptoms.
-𝙂𝙚𝙣𝙚 𝙑𝙖𝙧𝙞𝙖𝙣𝙩𝙨: Various mutations affect the production of hemoglobin and its ability to function properly.

2. 𝗜𝗺𝗽𝗮𝗰𝘁𝘀 𝗮𝗻𝗱 𝗖𝗼𝗺𝗽𝗹𝗶𝗰𝗮𝘁𝗶𝗼𝗻𝘀
- 𝗛𝗲𝗮𝗹𝘁𝗵 𝗘𝗳𝗳𝗲𝗰𝘁𝘀:
-𝗔𝗻𝗲𝗺𝗶𝗮: Reduced production of hemoglobin leads to a shortage of red blood cells, causing fatigue, weakness, and paleness.
-𝗖𝗼𝗺𝗽𝗹𝗶𝗰𝗮𝘁𝗶𝗼𝗻𝘀: Includes growth delays, bone deformities, and organ damage due to iron overload from frequent blood transfusions.

-𝗧𝗿𝗲𝗮𝘁𝗺𝗲𝗻𝘁:
-𝗥𝗲𝗴𝘂𝗹𝗮𝗿 𝗕𝗹𝗼𝗼𝗱 𝗧𝗿𝗮𝗻𝘀𝗳𝘂𝘀𝗶𝗼𝗻𝘀: To maintain adequate hemoglobin levels and manage anemia.
-𝗜𝗿𝗼𝗻 𝗖𝗵𝗲𝗹𝗮𝘁𝗶𝗼𝗻 𝗧𝗵𝗲𝗿𝗮𝗽𝘆: To prevent iron overload from transfusions.
-𝘽𝙤𝙣𝙚 𝙈𝙖𝙧𝙧𝙤𝙬 𝙏𝙧𝙖𝙣𝙨𝙥𝙡𝙖𝙣𝙩: Potentially curative treatment in some cases.
-𝗤𝘂𝗮𝗹𝗶𝘁𝘆 𝗼𝗳 𝗟𝗶𝗳𝗲: Individuals may experience limitations in daily activities, psychological stress, and financial burdens due to ongoing medical care.

This summary covers the genetic🧬 causes of thalassemia and its effects on people's lives. If your family👨‍👩‍👧‍👦 has a history of genetic disease, 𝗗𝗡𝗔 𝘁𝗲𝘀𝘁 can help you see if you or your children👧 have inherited it.

21/08/2024

16/08/2024

𝐖𝐡𝐚𝐭 𝐭𝐨 𝐊𝐧𝐨𝐰 𝐚𝐛𝐨𝐮𝐭 𝐄𝐜𝐳𝐞𝐦𝐚 𝐚𝐧𝐝 𝐆𝐞𝐧𝐞𝐭𝐢𝐜𝐬?

Eczema, also known as atopic dermatitis, is a skin condition that causes inflammation, itching, and redness. While the exact cause of eczema isn't fully understood, genetics play a significant role in its development. Here's what you should know about the connection between eczema and genetics:

1. 𝐆𝐞𝐧𝐞𝐭𝐢𝐜 𝐏𝐫𝐞𝐝𝐢𝐬𝐩𝐨𝐬𝐢𝐭𝐢𝐨𝐧
- Eczema often runs in families, suggesting a strong genetic component. If one or both parents have eczema, asthma, or hay fever (atopic conditions), their children are more likely to develop eczema.
- Several genes have been linked to eczema, including those involved in skin barrier function and immune system regulation.

2. 𝐒𝐤𝐢𝐧 𝐁𝐚𝐫𝐫𝐢𝐞𝐫 𝐆𝐞𝐧𝐞𝐬
- One key gene associated with eczema is the FLG gene, which produces filaggrin, a protein essential for maintaining the skin’s barrier. Mutations in the FLG gene can lead to a weakened skin barrier, making the skin more susceptible to irritants and allergens.

3. 𝐈𝐦𝐦𝐮𝐧𝐞 𝐒𝐲𝐬𝐭𝐞𝐦 𝐆𝐞𝐧𝐞𝐬
- Eczema is also linked to genes that influence the immune system. People with eczema often have an overactive immune response to environmental triggers, leading to inflammation and symptoms.

4. 𝐄𝐧𝐯𝐢𝐫𝐨𝐧𝐦𝐞𝐧𝐭𝐚𝐥 𝐓𝐫𝐢𝐠𝐠𝐞𝐫𝐬
- Although genetics play a crucial role, environmental factors like allergens, stress, and weather changes can trigger or worsen eczema symptoms. This interaction between genetics and the environment is known as the "atopic march," where individuals with a genetic predisposition are more vulnerable to these triggers.

5. 𝐇𝐞𝐫𝐞𝐝𝐢𝐭𝐚𝐫𝐲 𝐑𝐢𝐬𝐤
- While having a family history of eczema increases the risk, it doesn't guarantee that someone will develop the condition. Similarly, individuals without a family history can still develop eczema, indicating that other factors are also involved.

Genetics are a major factor in the development of eczema, particularly through genes that affect the skin barrier and immune system. However, environmental factors also play a significant role, and the condition can vary greatly in severity and triggers from person to person.